ENSMUSG00000022488


Mus musculus

Features
Gene ID: ENSMUSG00000022488
  
Biological name :Nckap1l
  
Synonyms : Nckap1l / Nck-associated protein 1-like / Q8K1X4
  
Possible biological names infered from orthology : P55160
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: F3
Gene start: 103453794
Gene end: 103498810
  
Corresponding Affymetrix probe sets: 10427336 (MoGene1.0st)   1428786_at (Mouse Genome 430 2.0 Array)   1428787_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000035400
Ensembl peptide - ENSMUSP00000154960
NCBI entrez gene - 105855     See in Manteia.
MGI - MGI:1926063
RefSeq - XM_006520255
RefSeq - NM_153505
RefSeq Peptide - NP_705725
swissprot - Q8K1X4
Ensembl - ENSMUSG00000022488
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NCKAP1LENSDARG00000075748Danio rerio
 P55160ENSG00000123338Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nckap1 / P28660 / Mus musculus NCK-associated protein 1 (Nckap1), transcript variant 4, mRNA. / Q9Y2A7* / NCK associated protein 1*ENSMUSG0000002700258


Protein motifs (from Interpro)
Interpro ID Name
 IPR019137  Nck-associated protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001782 B cell homeostasis IMP
 biological_processGO:0002262 myeloid cell homeostasis IMP
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0030011 maintenance of cell polarity IEA
 biological_processGO:0030593 neutrophil chemotaxis IEA
 biological_processGO:0030838 positive regulation of actin filament polymerization IEA
 biological_processGO:0030866 cortical actin cytoskeleton organization IEA
 biological_processGO:0030890 positive regulation of B cell proliferation IEA
 biological_processGO:0032147 activation of protein kinase activity IEA
 biological_processGO:0032700 negative regulation of interleukin-17 production IMP
 biological_processGO:0032715 negative regulation of interleukin-6 production IMP
 biological_processGO:0033630 positive regulation of cell adhesion mediated by integrin IMP
 biological_processGO:0034101 erythrocyte homeostasis IMP
 biological_processGO:0035509 negative regulation of myosin-light-chain-phosphatase activity IEA
 biological_processGO:0042102 positive regulation of T cell proliferation IMP
 biological_processGO:0042327 positive regulation of phosphorylation IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043029 T cell homeostasis IMP
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation IMP
 biological_processGO:0043378 positive regulation of CD8-positive, alpha-beta T cell differentiation IMP
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045579 positive regulation of B cell differentiation IMP
 biological_processGO:0045588 positive regulation of gamma-delta T cell differentiation IMP
 biological_processGO:0045621 positive regulation of lymphocyte differentiation IMP
 biological_processGO:0045648 positive regulation of erythrocyte differentiation IMP
 biological_processGO:0048821 erythrocyte development IEA
 biological_processGO:0050853 B cell receptor signaling pathway IEA
 biological_processGO:0060100 positive regulation of phagocytosis, engulfment IMP
 biological_processGO:0065003 protein-containing complex assembly IMP
 biological_processGO:0070358 actin polymerization-dependent cell motility IEA
 biological_processGO:0090023 positive regulation of neutrophil chemotaxis IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031209 SCAR complex IMP
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0030295 protein kinase activator activity IEA
 molecular_functionGO:0044877 protein-containing complex binding IEA


Pathways (from Reactome)
Pathway description
Regulation of actin dynamics for phagocytic cup formation
VEGFA-VEGFR2 Pathway
RHO GTPases Activate WASPs and WAVEs
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: KitlSl-3Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: KitlSl-3Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: KitlSl-3Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: KitlSl-3Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

 MP:0000314 schistocytosis "the appearance of poikilocytes in the blood that owe their abnormal shape to fragmentation occurring as the cells flow through damaged small vessels" [J:82330, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: KitlSl-3Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: KitlSl-3Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

 MP:0000604 amyloidosis "an accumulation of extracellular amyloid in tissues of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: KitlSl-3Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
Show

Allelic Composition: KitlSl-3Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

 MP:0001798 impaired macrophage phagocytosis "reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: KitlSl-3Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
Show

Allelic Composition: KitlSl-3Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

 MP:0001853 heart inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the heart" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: KitlSl-3Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: KitlSl-3Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: KitlSl-3Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

 MP:0002367 abnormal thymus lobule morphology "anomalous structure or development of the basic structural unit of the thymus" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: KitlSl-3Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

 MP:0002401 abnormal lymphopoiesis "atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: KitlSl-3Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

 MP:0002467 impaired neutrophil phagocytosis "reduced ability of these leukocytes to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: KitlSl-3Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: KitlSl-3Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: KitlSl-3Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: KitlSl-3Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

 MP:0002643 poikilocytosis "blood cells of variable shape on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: KitlSl-3Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: KitlSl-3Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: KitlSl-3Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

 MP:0003657 abnormal erythrocyte lysis "increase or decrease in the ability of RBCs to withstand changes in osmolarity" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: KitlSl-3Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

 MP:0004733 abnormal thoracic cavity "any structural anomaly of the cavity in the vertebrate body enclosed by the ribcage between the diaphragm and the neck, and contains the lungs, heart, thoracic aorta, pulmonary artery and its branches, thymus gland, and the respiratory airway" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: KitlSl-3Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

 MP:0004972 abnormal regulatory T cell number "deviation from the average count of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: KitlSl-3Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: KitlSl-3Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: KitlSl-3Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: KitlSl-3Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: KitlSl-3Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: KitlSl-3Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: KitlSl-3Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: KitlSl-3Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

 MP:0008076 abnormal CD4-positive T cell differentiation "atypical production of or inability to produce the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: KitlSl-3Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: KitlSl-3Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

 MP:0008101 lymph node hypoplasia "underdevelopment or reduced size, usually due to a reduced cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: KitlSl-3Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
Show

Allelic Composition: KitlSl-3Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

 MP:0008354 decreased mature gamma-delta T cell number "reduced number of a mature T cell expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
Show

Allelic Composition: KitlSl-3Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

 MP:0008388 hypochromic microcytic anemia "hemoglobin deficiency resulting from a reduction in the concentration of hemoglobin in red cells, where the erythrocyte corpuscular volume is smaller than normal" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: KitlSl-3Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: KitlSl-3Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: KitlSl-3Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

 MP:0008614 increased circulating interleukin-17 level "increase in the amount in the blood of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
Show

Allelic Composition: KitlSl-3Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

 MP:0008681 increased interleukin-17 secretion "increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
Show

Allelic Composition: KitlSl-3Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: KitlSl-3Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

 MP:0008720 impaired neutrophil migration "defect in the ability of neutrophils to move along a chemotactic gradient" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: KitlSl-3Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

 MP:0008801 abnormal erythroid progenitor cell morphology "any structural anomaly of a progenitor cell committed to the erythroid lineage" [CL:0000038]
Show

Allelic Composition: KitlSl-3Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

 MP:0010176 dacryocytosis "presence of teardrop-shaped red blood cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: KitlSl-3Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

 MP:0010177 acanthocytosis "presence of erythrocytes characterized by multiple spiny (thorn-like) cytoplasmic projections" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: KitlSl-3Neu/Kitl+
Genetic Background: involves: 102/El * C3H/El

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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