ENSG00000124422


Homo sapiens

Features
Gene ID: ENSG00000124422
  
Biological name :USP22
  
Synonyms : Q9UPT9 / ubiquitin specific peptidase 22 / USP22
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: p11.2
Gene start: 20999593
Gene end: 21043760
  
Corresponding Affymetrix probe sets: 200083_at (Human Genome U133 Plus 2.0 Array)   216957_at (Human Genome U133 Plus 2.0 Array)   216964_at (Human Genome U133 Plus 2.0 Array)   220861_at (Human Genome U133 Plus 2.0 Array)   220862_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000468748
Ensembl peptide - ENSP00000464499
Ensembl peptide - ENSP00000468457
Ensembl peptide - ENSP00000261497
Ensembl peptide - ENSP00000440950
Ensembl peptide - ENSP00000464398
NCBI entrez gene - 23326     See in Manteia.
OMIM - 612116
RefSeq - XM_005256575
RefSeq - NM_015276
RefSeq Peptide - NP_056091
swissprot - K7ERX6
swissprot - K7ESK0
swissprot - J3QRV6
swissprot - Q9UPT9
swissprot - J3QS30
Ensembl - ENSG00000124422
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 usp22ENSDARG00000040407Danio rerio
 Usp22ENSMUSG00000042506Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
USP51 / Q70EK9 / ubiquitin specific peptidase 51ENSG0000024774671
A6NNY8 / USP27X / ubiquitin specific peptidase 27, X-linkedENSG0000027382067
USP44 / Q9H0E7 / ubiquitin specific peptidase 44ENSG0000013601429
USP49 / Q70CQ1 / ubiquitin specific peptidase 49ENSG0000016466327
USP3 / Q9Y6I4 / ubiquitin specific peptidase 3ENSG0000014045526
USP36 / Q9P275 / ubiquitin specific peptidase 36ENSG0000005548321
USP42 / Q9H9J4 / ubiquitin specific peptidase 42ENSG0000010634621
C9JLJ4 / USP17L13 / ubiquitin specific peptidase 17-like family member 13ENSG0000023239921
D6RBQ6 / USP17L17 / ubiquitin specific peptidase 17-like family member 17ENSG0000024910421
Q6R6M4 / USP17L2 / ubiquitin specific peptidase 17-like family member 2ENSG0000022344320
C9J2P7 / USP17L15 / ubiquitin specific peptidase 17-like family member 15ENSG0000022356920
A6NCW0 / USP17L3 / ubiquitin specific peptidase 17-like family member 3ENSG0000022532720
A8MUK1 / USP17L5 / ubiquitin specific peptidase 17-like family member 5ENSG0000022714020
C9JPN9 / USP17L12 / ubiquitin specific peptidase 17-like family member 12ENSG0000022755120
Q0WX57 / USP17L30 / ubiquitin specific peptidase 17-like family member 30ENSG0000022885620
Q0WX57 / USP17L26 / ubiquitin specific peptidase 17-like family member 26ENSG0000022957920
Q0WX57 / USP17L25 / ubiquitin specific peptidase 17-like family member 25ENSG0000023043020
Q7RTZ2 / USP17L1 / ubiquitin specific peptidase 17-like family member 1ENSG0000023054920
Q0WX57 / USP17L28 / ubiquitin specific peptidase 17-like family member 28ENSG0000023105120
C9JJH3 / USP17L10 / ubiquitin specific peptidase 17-like family member 10ENSG0000023139620


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR001607  Zinc finger, UBP-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028889  Ubiquitin specific protease domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0009792 embryo development ending in birth or egg hatching NAS
 biological_processGO:0016574 histone ubiquitination IDA
 biological_processGO:0016578 histone deubiquitination IDA
 biological_processGO:0016579 protein deubiquitination IEA
 biological_processGO:0043967 histone H4 acetylation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0045931 positive regulation of mitotic cell cycle IMP
 cellular_componentGO:0000124 SAGA complex IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0016607 nuclear speck IDA
 cellular_componentGO:0070461 SAGA-type complex IDA
 molecular_functionGO:0003713 transcription coactivator activity IDA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0010485 H4 histone acetyltransferase activity IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0030374 nuclear receptor transcription coactivator activity IMP
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
HATs acetylate histones
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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