ENSG00000127603


Homo sapiens
bindingMACF1domainregulationmembranecellrepeatef-handsuperfamilymicrotubuleactinsitespectringarmigrationwntsignalingpathwaygolgiplasmaproteincytoskeletonionplectinactinin-typeactin-bindingconservedcalponinhomologypairalpha-actinin

Features
Gene ID: ENSG00000127603
  
Biological name :MACF1
  
Synonyms : MACF1 / microtubule-actin crosslinking factor 1 / Q9UPN3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p34.3
Gene start: 39081316
Gene end: 39487177
  
Corresponding Affymetrix probe sets: 1553407_at (Human Genome U133 Plus 2.0 Array)   207358_x_at (Human Genome U133 Plus 2.0 Array)   208633_s_at (Human Genome U133 Plus 2.0 Array)   208634_s_at (Human Genome U133 Plus 2.0 Array)   214894_x_at (Human Genome U133 Plus 2.0 Array)   215222_x_at (Human Genome U133 Plus 2.0 Array)   215268_at (Human Genome U133 Plus 2.0 Array)   232168_x_at (Human Genome U133 Plus 2.0 Array)   239009_at (Human Genome U133 Plus 2.0 Array)   241896_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000435070
Ensembl peptide - ENSP00000431179
Ensembl peptide - ENSP00000434859
Ensembl peptide - ENSP00000435078
Ensembl peptide - ENSP00000492962
Ensembl peptide - ENSP00000473615
Ensembl peptide - ENSP00000455823
Ensembl peptide - ENSP00000455274
Ensembl peptide - ENSP00000437059
Ensembl peptide - ENSP00000435892
Ensembl peptide - ENSP00000289893
Ensembl peptide - ENSP00000353231
Ensembl peptide - ENSP00000354573
Ensembl peptide - ENSP00000362006
Ensembl peptide - ENSP00000362016
Ensembl peptide - ENSP00000391512
Ensembl peptide - ENSP00000407776
Ensembl peptide - ENSP00000412910
NCBI entrez gene - 643314     See in Manteia.
NCBI entrez gene - 23499     See in Manteia.
OMIM - 608271
RefSeq - XM_017000882
RefSeq - XM_006710531
RefSeq - XM_006710532
RefSeq - XM_006710533
RefSeq - XM_006710535
RefSeq - XM_006710536
RefSeq - XM_006710538
RefSeq - XM_011541141
RefSeq - XM_011541142
RefSeq - XM_017000873
RefSeq - XM_017000874
RefSeq - XM_017000875
RefSeq - XM_017000876
RefSeq - XM_017000877
RefSeq - XM_017000878
RefSeq - XM_017000879
RefSeq - XM_017000880
RefSeq - XM_017000881
RefSeq - NM_012090
RefSeq - NM_015038
RefSeq - XM_005270694
RefSeq - XM_005270695
RefSeq - XM_005270696
RefSeq - XM_005270697
RefSeq - XM_005270698
RefSeq - XM_006710519
RefSeq - XM_006710520
RefSeq - XM_006710521
RefSeq - XM_006710522
RefSeq - XM_006710524
RefSeq - XM_006710526
RefSeq - XM_006710528
RefSeq - XM_006710529
RefSeq - XM_006710530
RefSeq Peptide - NP_036222
RefSeq Peptide - NP_055853
swissprot - E9PLY5
swissprot - E9PLY0
swissprot - B4DQX9
swissprot - A0A286YES6
swissprot - H0Y314
swissprot - H0Y390
swissprot - E9PS75
swissprot - H0Y6T5
swissprot - H0Y7I1
swissprot - H3BPE1
swissprot - H3BQK9
swissprot - Q9UPN3
swissprot - A0A0A6YYJ5
swissprot - H0Y4F5
swissprot - E9PNZ4
Ensembl - ENSG00000127603
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 macf1aENSDARG00000028533Danio rerio
 MACF1ENSGALG00000003693Gallus gallus
 Macf1ENSMUSG00000028649Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DST / Q03001 / dystoninENSG0000015191456
PLEC / Q15149 / plectinENSG0000017820919
DSP / P15924 / desmoplakinENSG0000009669610
EVPL / Q92817 / envoplakinENSG000001678807
PPL / O60437 / periplakinENSG000001188986
EPPK1 / epiplakin 1ENSG000002611504
EVPLL / A8MZ36 / envoplakin likeENSG000002148601


Protein motifs (from Interpro)
Interpro ID Name
 IPR001101  Plectin repeat
 IPR001589  Actinin-type actin-binding domain, conserved site
 IPR001715  Calponin homology domain
 IPR002017  Spectrin repeat
 IPR002048  EF-hand domain
 IPR003108  GAR domain
 IPR011992  EF-hand domain pair
 IPR018159  Spectrin/alpha-actinin
 IPR018247  EF-Hand 1, calcium-binding site
 IPR035915  Plakin repeat superfamily
 IPR036534  GAR domain superfamily
 IPR036872  CH domain superfamily


Gene Ontology (GO)
localization of cellmovement of cell or subcellular componenttissue migrationcell communicationcellular response to stimulusmicrotubule-based processresponse to stressmacromolecule localizationestablishment of localizationcellular localizationcellular component organizationregulation of biological qualityanatomical structure developmentcellular developmental processcell growthdevelopmental growthcellular component biogenesiscell adhesionlocalization of cellmovement of cell or subcellular componenttissue migrationcell communicationcellular response to stimulusmicrotubule-based processresponse to stressmacromolecule localizationestablishment of localizationcellular localizationcellular component organizationregulation of biological qualityanatomical structure developmentcellular developmental processcell growthdevelopmental growthcellular component biogenesiscell adhesionlocalization of cellmovement of cell or subcellular componenttissue migrationcell communicationcellular response to stimulusmicrotubule-based processresponse to stressmacromolecule localizationestablishment of localizationcellular localizationcellular component organizationregulation of biological qualityanatomical structure developmentcellular developmental processcell growthdevelopmental growthcellular component biogenesiscell adhesionlocalization of cellmovement of cell or subcellular componenttissue migrationcell communicationcellular response to stimulusmicrotubule-based processresponse to stressmacromolecule localizationestablishment of localizationcellular localizationcellular component organizationregulation of biological qualityanatomical structure developmentcellular developmental processcell growthdevelopmental growthcellular component biogenesiscell adhesionlocalization of cellmovement of cell or subcellular componenttissue migrationcell communicationcellular response to stimulusmicrotubule-based processresponse to stressmacromolecule localizationestablishment of localizationcellular localizationcellular component organizationregulation of biological qualityanatomical structure developmentcellular developmental processcell growthdevelopmental growthcellular component biogenesiscell adhesionlocalization of cellmovement of cell or subcellular componenttissue migrationcell communicationcellular response to stimulusmicrotubule-based processresponse to stressmacromolecule localizationestablishment of localizationcellular localizationcellular component organizationregulation of biological qualityanatomical structure developmentcellular developmental processcell growthdevelopmental growthcellular component biogenesiscell adhesionlocalization of cellmovement of cell or subcellular componenttissue migrationcell communicationcellular response to stimulusmicrotubule-based processresponse to stressmacromolecule localizationestablishment of localizationcellular localizationcellular component organizationregulation of biological qualityanatomical structure developmentcellular developmental processcell growthdevelopmental growthcellular component biogenesiscell adhesionlocalization of cellmovement of cell or subcellular componenttissue migrationcell communicationcellular response to stimulusmicrotubule-based processresponse to stressmacromolecule localizationestablishment of localizationcellular localizationcellular component organizationregulation of biological qualityanatomical structure developmentcellular developmental processcell growthdevelopmental growthcellular component biogenesiscell adhesionlocalization of cellmovement of cell or subcellular componenttissue migrationcell communicationcellular response to stimulusmicrotubule-based processresponse to stressmacromolecule localizationestablishment of localizationcellular localizationcellular component organizationregulation of biological qualityanatomical structure developmentcellular developmental processcell growthdevelopmental growthcellular component biogenesiscell adhesionlocalization of cellmovement of cell or subcellular componenttissue migrationcell communicationcellular response to stimulusmicrotubule-based processresponse to stressmacromolecule localizationestablishment of localizationcellular localizationcellular component organizationregulation of biological qualityanatomical structure developmentcellular developmental processcell growthdevelopmental growthcellular component biogenesiscell adhesionlocalizlocalization of cellmovemenmovement of cell or subcellular componenttissue tissue migrationcell cocell communicationcellulacellular response to stimulusmicrotumicrotubule-based processresponsresponse to stressmacromomacromolecule localizationestabliestablishment of localizationcellulacellular localizationcellulacellular component organizationregulatregulation of biological qualityanatomianatomical structure developmentcellulacellular developmental processcell grcell growthdevelopdevelopmental growthcellulacellular component biogenesiscell adcell adhesion
organic cyclic compound bindingheterocyclic compound bindingprotein bindingion bindinghydrolase activityprotein-containing complex bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingion bindinghydrolase activityprotein-containing complex bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingion bindinghydrolase activityprotein-containing complex bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingion bindinghydrolase activityprotein-containing complex bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingion bindinghydrolase activityprotein-containing complex bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingion bindinghydrolase activityprotein-containing complex bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingion bindinghydrolase activityprotein-containing complex bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingion bindinghydrolase activityprotein-containing complex bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingion bindinghydrolase activityprotein-containing complex bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingion bindinghydrolase activityprotein-containing complex bindingorganic cyclic compoundorganic cyclic compound bindingheterocyclic compound bheterocyclic compound bindingprotein bindingprotein bindingion bindingion bindinghydrolase activityhydrolase activityprotein-containing compprotein-containing complex binding
cellorganellesupramolecular complexmembranecell junctioncellorganellesupramolecular complexmembranecell junctioncellorganellesupramolecular complexmembranecell junctioncellorganellesupramolecular complexmembranecell junctioncellorganellesupramolecular complexmembranecell junctioncellorganellesupramolecular complexmembranecell junctioncellorganellesupramolecular complexmembranecell junctioncellorganellesupramolecular complexmembranecell junctioncellorganellesupramolecular complexmembranecell junctioncellorganellesupramolecular complexmembranecell junctioncellcellorganelleorganellesupramolecular complexsupramolecular complexmembranemembranecell junctioncell junction
TypeGO IDTermEv.Code
 biological_processGO:0010632 regulation of epithelial cell migration ISS
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030177 positive regulation of Wnt signaling pathway ISS
 biological_processGO:0030334 regulation of cell migration IDA
 biological_processGO:0032886 regulation of microtubule-based process IMP
 biological_processGO:0042060 wound healing ISS
 biological_processGO:0043001 Golgi to plasma membrane protein transport IDA
 biological_processGO:0045773 positive regulation of axon extension IDA
 biological_processGO:0051893 regulation of focal adhesion assembly ISS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0015629 actin cytoskeleton IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IDA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0016887 ATPase activity ISS
 molecular_functionGO:0045296 cadherin binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051011 microtubule minus-end binding IDA
 molecular_functionGO:0051015 actin filament binding NAS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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