ENSG00000132718


Homo sapiens
regulationSYT11membranevesiclebindingproteinendocytosisplasmasecretionsynapticphagocyticsynapsecdomainresponseneurotransmittercalciumexocytosisfactorphagosomeionlysosomecytoplasmintegralcomponentcellclathrin-mediatedsynaptotagminsynaptotagmin-superfamilyrepair

Features
Gene ID: ENSG00000132718
  
Biological name :SYT11
  
Synonyms : Q9BT88 / synaptotagmin 11 / SYT11
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q22
Gene start: 155859509
Gene end: 155885199
  
Corresponding Affymetrix probe sets: 209197_at (Human Genome U133 Plus 2.0 Array)   209198_s_at (Human Genome U133 Plus 2.0 Array)   232677_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000357307
NCBI entrez gene - 23208     See in Manteia.
OMIM - 608741
RefSeq - XM_017000759
RefSeq - NM_152280
RefSeq - XM_005245014
RefSeq Peptide - NP_689493
swissprot - Q9BT88
Ensembl - ENSG00000132718
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 syt11aENSDARG00000057913Danio rerio
 syt11bENSDARG00000056105Danio rerio
 SYT11ENSGALG00000014646Gallus gallus
 Syt11ENSMUSG00000068923Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SYT4 / Q9H2B2 / synaptotagmin 4ENSG0000013287252
SYT7 / O43581 / synaptotagmin 7ENSG0000001134733
SYT1 / P21579 / synaptotagmin 1ENSG0000006771530
SYT10 / Q6XYQ8 / synaptotagmin 10ENSG0000011097530
SYT5 / O00445 / synaptotagmin 5ENSG0000012999030
SYT6 / Q5T7P8 / synaptotagmin 6ENSG0000013420729
SYT2 / Q8N9I0 / synaptotagmin 2ENSG0000014385829
SYT3 / Q9BQG1 / synaptotagmin 3ENSG0000021302329
SYT9 / Q86SS6 / synaptotagmin 9ENSG0000017074328
SYT8 / Q8NBV8 / synaptotagmin 8ENSG0000014904325


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR001565  Synaptotagmin
 IPR028699  Synaptotagmin-11
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
response to stresscellular component organizationestablishment of localizationcell communicationregulation of biological qualitycellular localizationcellular component biogenesismacromolecule localizationcytokine productionresponse to external stimulusresponse to biotic stimulusresponse to stresscellular component organizationestablishment of localizationcell communicationregulation of biological qualitycellular localizationcellular component biogenesismacromolecule localizationcytokine productionresponse to external stimulusresponse to biotic stimulusresponse to stresscellular component organizationestablishment of localizationcell communicationregulation of biological qualitycellular localizationcellular component biogenesismacromolecule localizationcytokine productionresponse to external stimulusresponse to biotic stimulusresponse to stresscellular component organizationestablishment of localizationcell communicationregulation of biological qualitycellular localizationcellular component biogenesismacromolecule localizationcytokine productionresponse to external stimulusresponse to biotic stimulusresponse to stresscellular component organizationestablishment of localizationcell communicationregulation of biological qualitycellular localizationcellular component biogenesismacromolecule localizationcytokine productionresponse to external stimulusresponse to biotic stimulusresponse to stresscellular component organizationestablishment of localizationcell communicationregulation of biological qualitycellular localizationcellular component biogenesismacromolecule localizationcytokine productionresponse to external stimulusresponse to biotic stimulusresponse to stresscellular component organizationestablishment of localizationcell communicationregulation of biological qualitycellular localizationcellular component biogenesismacromolecule localizationcytokine productionresponse to external stimulusresponse to biotic stimulusresponse to stresscellular component organizationestablishment of localizationcell communicationregulation of biological qualitycellular localizationcellular component biogenesismacromolecule localizationcytokine productionresponse to external stimulusresponse to biotic stimulusresponse to stresscellular component organizationestablishment of localizationcell communicationregulation of biological qualitycellular localizationcellular component biogenesismacromolecule localizationcytokine productionresponse to external stimulusresponse to biotic stimulusresponse to stresscellular component organizationestablishment of localizationcell communicationregulation of biological qualitycellular localizationcellular component biogenesismacromolecule localizationcytokine productionresponse to external stimulusresponse to biotic stimulusresponse to response to stresscellular comcellular component organizationestablishmenestablishment of localizationcell communicell communicationregulation oregulation of biological qualitycellular loccellular localizationcellular comcellular component biogenesismacromoleculmacromolecule localizationcytokine procytokine productionresponse to response to external stimulusresponse to response to biotic stimulus
protein bindingion bindingprotein bindingion bindingprotein bindingion bindingprotein bindingion bindingprotein bindingion bindingprotein bindingion bindingprotein bindingion bindingprotein bindingion bindingprotein bindingion bindingprotein bindingion bindingprotein bindingprotein bindingion bindingion binding
cellmembraneorganellesynapsecell junctioncellmembraneorganellesynapsecell junctioncellmembraneorganellesynapsecell junctioncellmembraneorganellesynapsecell junctioncellmembraneorganellesynapsecell junctioncellmembraneorganellesynapsecell junctioncellmembraneorganellesynapsecell junctioncellmembraneorganellesynapsecell junctioncellmembraneorganellesynapsecell junctioncellmembraneorganellesynapsecell junctioncellcellmembranemembraneorganelleorganellesynapsesynapsecell junctioncell junction
TypeGO IDTermEv.Code
 biological_processGO:0001778 plasma membrane repair IEA
 biological_processGO:0006906 vesicle fusion IBA
 biological_processGO:0009611 response to wounding IEA
 biological_processGO:0046929 negative regulation of neurotransmitter secretion TAS
 biological_processGO:0048791 calcium ion-regulated exocytosis of neurotransmitter IBA
 biological_processGO:0050765 negative regulation of phagocytosis IEA
 biological_processGO:0051289 protein homotetramerization IEA
 biological_processGO:1900165 negative regulation of interleukin-6 secretion IEA
 biological_processGO:1900186 negative regulation of clathrin-dependent endocytosis IEA
 biological_processGO:1900243 negative regulation of synaptic vesicle endocytosis IEA
 biological_processGO:1900424 regulation of defense response to bacterium IEA
 biological_processGO:1904468 negative regulation of tumor necrosis factor secretion IEA
 biological_processGO:1905154 negative regulation of membrane invagination IEA
 biological_processGO:1905162 regulation of phagosome maturation IC
 biological_processGO:1905171 positive regulation of protein localization to phagocytic vesicle IEA
 biological_processGO:1905469 negative regulation of clathrin-coated pit assembly IEA
 biological_processGO:1990927 calcium ion regulated lysosome exocytosis IEA
 cellular_componentGO:0001891 phagocytic cup IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0008021 synaptic vesicle IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030672 synaptic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031982 vesicle IEA
 cellular_componentGO:0032009 early phagosome IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043195 terminal bouton IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0044297 cell body IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045335 phagocytic vesicle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0048787 presynaptic active zone membrane IEA
 cellular_componentGO:0055037 recycling endosome IEA
 cellular_componentGO:0060076 excitatory synapse IEA
 cellular_componentGO:0060077 inhibitory synapse IEA
 cellular_componentGO:0098793 presynapse IEA
 molecular_functionGO:0000149 SNARE binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019905 syntaxin binding IBA
 molecular_functionGO:0030276 clathrin binding IBA
 molecular_functionGO:0031369 translation initiation factor binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048487 beta-tubulin binding IEA


Pathways (from Reactome)
Pathway description
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000132718 SYT11 / Q9BT88 / synaptotagmin 11  / complex






 

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