ENSG00000134765


Homo sapiens
cadherinmembraneDSC1bindingcelladhesiondomainplasmakeratinizationneutrophildegranulationcornifiedenvelopejunctionioncytoplasmicdesmosomalprodomaincadherin-likeconservedsitecateninsuperfamilyhomophilicviamoleculescornificationgapintegralcomponentdesmosome

Features
Gene ID: ENSG00000134765
  
Biological name :DSC1
  
Synonyms : desmocollin 1 / DSC1 / Q08554
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 18
Strand: -1
Band: q12.1
Gene start: 31129236
Gene end: 31162856
  
Corresponding Affymetrix probe sets: 207324_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000257197
Ensembl peptide - ENSP00000257198
NCBI entrez gene - 1823     See in Manteia.
OMIM - 125643
RefSeq - NM_024421
RefSeq - NM_004948
RefSeq Peptide - NP_004939
RefSeq Peptide - NP_077739
swissprot - Q08554
swissprot - Q9HB00
Ensembl - ENSG00000134765
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dsc2lENSDARG00000039677Danio rerio
 ENSGALG00000015140Gallus gallus
 Dsc1ENSMUSG00000044322Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DSC2 / Q02487 / desmocollin 2ENSG0000013475555
DSC3 / Q14574 / desmocollin 3ENSG0000013476251
CDH2 / P19022 / cadherin 2ENSG0000017055832
CDH1 / P12830 / cadherin 1ENSG0000003906830
CDH4 / P55283 / cadherin 4ENSG0000017924230
CDH3 / P22223 / cadherin 3ENSG0000006203827
CDH26 / Q8IXH8 / cadherin 26ENSG0000012421526
CDH15 / P55291 / cadherin 15ENSG0000012991026
CDH13 / P55290 / cadherin 13ENSG0000014094524


Protein motifs (from Interpro)
Interpro ID Name
 IPR000233  Cadherin, cytoplasmic domain
 IPR002126  Cadherin
 IPR009122  Desmosomal cadherin
 IPR014868  Cadherin prodomain
 IPR015919  Cadherin-like
 IPR020894  Cadherin conserved site
 IPR027397  Catenin binding domain superfamily


Gene Ontology (GO)
cell adhesionanatomical structure developmentcellular developmental processimmune responseestablishment of localizationcell activationimmune effector processcell deathcell adhesionanatomical structure developmentcellular developmental processimmune responseestablishment of localizationcell activationimmune effector processcell deathcell adhesionanatomical structure developmentcellular developmental processimmune responseestablishment of localizationcell activationimmune effector processcell deathcell adhesionanatomical structure developmentcellular developmental processimmune responseestablishment of localizationcell activationimmune effector processcell deathcell adhesionanatomical structure developmentcellular developmental processimmune responseestablishment of localizationcell activationimmune effector processcell deathcell adhesionanatomical structure developmentcellular developmental processimmune responseestablishment of localizationcell activationimmune effector processcell deathcell adhesionanatomical structure developmentcellular developmental processimmune responseestablishment of localizationcell activationimmune effector processcell deathcell adhesionanatomical structure developmentcellular developmental processimmune responseestablishment of localizationcell activationimmune effector processcell deathcell adhesionanatomical structure developmentcellular developmental processimmune responseestablishment of localizationcell activationimmune effector processcell deathcell adhesionanatomical structure developmentcellular developmental processimmune responseestablishment of localizationcell activationimmune effector processcell deathcell adhesioncell adhesionanatomical structanatomical structure developmentcellular developmcellular developmental processimmune responseimmune responseestablishment of establishment of localizationcell activationcell activationimmune effector pimmune effector processcell deathcell death
ion bindingion bindingion bindingion bindingion bindingion bindingion bindingion bindingion bindingion bindingion bindingion binding
cellmembranecell junctionorganelleextracellular regioncellmembranecell junctionorganelleextracellular regioncellmembranecell junctionorganelleextracellular regioncellmembranecell junctionorganelleextracellular regioncellmembranecell junctionorganelleextracellular regioncellmembranecell junctionorganelleextracellular regioncellmembranecell junctionorganelleextracellular regioncellmembranecell junctionorganelleextracellular regioncellmembranecell junctionorganelleextracellular regioncellmembranecell junctionorganelleextracellular regioncellcellmembranemembranecell junctioncell junctionorganelleorganelleextracellular regionextracellular region
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA
 biological_processGO:0031424 keratinization TAS
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0070268 cornification TAS
 cellular_componentGO:0001533 cornified envelope TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005921 gap junction TAS
 cellular_componentGO:0016020 membrane TAS
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030057 desmosome IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0101003 ficolin-1-rich granule membrane TAS
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation
Keratinization
Formation of the cornified envelope


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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