ENSG00000138135


Homo sapiens
processCH25Hbiosyntheticactivitymetabolicsteroidbilemembraneacidhydroxylaselipidcholesterolendoplasmicreticulumionbindingfattysterolbcellchemotaxisoxidation-reductioncytosolintegralcomponent-hydroxylasemonooxygenaseironoxidoreductasemetalsynthesis

Features
Gene ID: ENSG00000138135
  
Biological name :CH25H
  
Synonyms : CH25H / cholesterol 25-hydroxylase / O95992
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: -1
Band: q23.31
Gene start: 89205629
Gene end: 89207314
  
Corresponding Affymetrix probe sets: 206932_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000360918
NCBI entrez gene - 9023     See in Manteia.
OMIM - 604551
RefSeq - NM_003956
RefSeq Peptide - NP_003947
swissprot - O95992
Ensembl - ENSG00000138135
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CR762390.1ENSDARG00000093818Danio rerio
 CH25HENSGALG00000006352Gallus gallus
 Ch25hENSMUSG00000050370Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MSMO1 / Q15800 / methylsterol monooxygenase 1ENSG0000005280224
FAXDC2 / Q96IV6 / fatty acid hydroxylase domain containing 2ENSG0000017027114


Protein motifs (from Interpro)
Interpro ID Name
 IPR006694  Fatty acid hydroxylase


Gene Ontology (GO)
primary metabolic processorganic substance metabolic processbiosynthetic processcellular metabolic processsmall molecule metabolic processresponse to external stimulusresponse to chemicallocalization of cellmovement of cell or subcellular componentcellular response to stimulusoxidation-reduction processprimary metabolic processorganic substance metabolic processbiosynthetic processcellular metabolic processsmall molecule metabolic processresponse to external stimulusresponse to chemicallocalization of cellmovement of cell or subcellular componentcellular response to stimulusoxidation-reduction processprimary metabolic processorganic substance metabolic processbiosynthetic processcellular metabolic processsmall molecule metabolic processresponse to external stimulusresponse to chemicallocalization of cellmovement of cell or subcellular componentcellular response to stimulusoxidation-reduction processprimary metabolic processorganic substance metabolic processbiosynthetic processcellular metabolic processsmall molecule metabolic processresponse to external stimulusresponse to chemicallocalization of cellmovement of cell or subcellular componentcellular response to stimulusoxidation-reduction processprimary metabolic processorganic substance metabolic processbiosynthetic processcellular metabolic processsmall molecule metabolic processresponse to external stimulusresponse to chemicallocalization of cellmovement of cell or subcellular componentcellular response to stimulusoxidation-reduction processprimary metabolic processorganic substance metabolic processbiosynthetic processcellular metabolic processsmall molecule metabolic processresponse to external stimulusresponse to chemicallocalization of cellmovement of cell or subcellular componentcellular response to stimulusoxidation-reduction processprimary metabolic processorganic substance metabolic processbiosynthetic processcellular metabolic processsmall molecule metabolic processresponse to external stimulusresponse to chemicallocalization of cellmovement of cell or subcellular componentcellular response to stimulusoxidation-reduction processprimary metabolic processorganic substance metabolic processbiosynthetic processcellular metabolic processsmall molecule metabolic processresponse to external stimulusresponse to chemicallocalization of cellmovement of cell or subcellular componentcellular response to stimulusoxidation-reduction processprimary metabolic processorganic substance metabolic processbiosynthetic processcellular metabolic processsmall molecule metabolic processresponse to external stimulusresponse to chemicallocalization of cellmovement of cell or subcellular componentcellular response to stimulusoxidation-reduction processprimary metabolic processorganic substance metabolic processbiosynthetic processcellular metabolic processsmall molecule metabolic processresponse to external stimulusresponse to chemicallocalization of cellmovement of cell or subcellular componentcellular response to stimulusoxidation-reduction processprimary metaprimary metabolic processorganic subsorganic substance metabolic processbiosyntheticbiosynthetic processcellular metcellular metabolic processsmall molecusmall molecule metabolic processresponse to response to external stimulusresponse to response to chemicallocalizationlocalization of cellmovement of movement of cell or subcellular componentcellular rescellular response to stimulusoxidation-reoxidation-reduction process
oxidoreductase activityion bindingoxidoreductase activityion bindingoxidoreductase activityion bindingoxidoreductase activityion bindingoxidoreductase activityion bindingoxidoreductase activityion bindingoxidoreductase activityion bindingoxidoreductase activityion bindingoxidoreductase activityion bindingoxidoreductase activityion bindingoxidoreductase activityoxidoreductase activityion bindingion binding
cellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellcellorganelleorganellemembranemembrane
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process TAS
 biological_processGO:0006694 steroid biosynthetic process IEA
 biological_processGO:0006699 bile acid biosynthetic process TAS
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0008610 lipid biosynthetic process IEA
 biological_processGO:0016126 sterol biosynthetic process IEA
 biological_processGO:0035754 B cell chemotaxis IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IBA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0001567 cholesterol 25-hydroxylase activity ISS
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0008395 steroid hydroxylase activity TAS
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of bile acids and bile salts


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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