ENSMUSG00000050370


Mus musculus

Features
Gene ID: ENSMUSG00000050370
  
Biological name :Ch25h
  
Synonyms : Ch25h / Cholesterol 25-hydroxylase / Q9Z0F5
  
Possible biological names infered from orthology : O95992
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: C1
Gene start: 34473786
Gene end: 34475135
  
Corresponding Affymetrix probe sets: 10467136 (MoGene1.0st)   1449227_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000049683
NCBI entrez gene - 12642     See in Manteia.
MGI - MGI:1333869
RefSeq - NM_009890
RefSeq Peptide - NP_034020
swissprot - Q9Z0F5
Ensembl - ENSMUSG00000050370
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CR762390.1ENSDARG00000093818Danio rerio
 CH25HENSGALG00000006352Gallus gallus
 CH25HENSG00000138135Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Msmo1 / Q9CRA4 / Methylsterol monooxygenase 1 / Q15800*ENSMUSG0000003160423
Gm12248 / fatty acid hydroxylase domain containing 2 / FAXDC2* / Q96IV6*ENSMUSG0000008696213


Protein motifs (from Interpro)
Interpro ID Name
 IPR006694  Fatty acid hydroxylase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006694 steroid biosynthetic process IEA
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process IDA
 biological_processGO:0008610 lipid biosynthetic process IEA
 biological_processGO:0016126 sterol biosynthetic process IEA
 biological_processGO:0035754 B cell chemotaxis IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0001567 cholesterol 25-hydroxylase activity IMP
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0008395 steroid hydroxylase activity IDA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of bile acids and bile salts


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Crptm1Hjf/Crptm1Hjf,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.Cg-Crptm1Hjf Ldlrtm1Her

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Crptm1Hjf/Crptm1Hjf,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.Cg-Crptm1Hjf Ldlrtm1Her

 MP:0008501 increased IgG2b level "greater than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Crptm1Hjf/Crptm1Hjf,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.Cg-Crptm1Hjf Ldlrtm1Her

 MP:0008502 increased IgG3 level "greater than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Crptm1Hjf/Crptm1Hjf,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.Cg-Crptm1Hjf Ldlrtm1Her

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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