ENSG00000139292


Homo sapiens
receptorLGR5membraneleucine-richrepeatactivitysignalingregulationrhodopsin-likedomaindevelopmentsignalg-proteincoupledpathwaycellproliferationplasmaintegralcomponentgprotein-coupledn-terminalglycoproteinhormonefamilytypicalsubtypegpcrtmsuperfamily

Features
Gene ID: ENSG00000139292
  
Biological name :LGR5
  
Synonyms : leucine rich repeat containing G protein-coupled receptor 5 / LGR5 / O75473
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q21.1
Gene start: 71439770
Gene end: 71586310
  
Corresponding Affymetrix probe sets: 210393_at (Human Genome U133 Plus 2.0 Array)   213880_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000443033
Ensembl peptide - ENSP00000266674
Ensembl peptide - ENSP00000441035
NCBI entrez gene - 8549     See in Manteia.
OMIM - 606667
RefSeq - NM_001277226
RefSeq - NM_001277227
RefSeq - NM_003667
RefSeq Peptide - NP_001264155
RefSeq Peptide - NP_001264156
RefSeq Peptide - NP_003658
swissprot - O75473
swissprot - A0A0A8K8C7
Ensembl - ENSG00000139292
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LGR5ENSGALG00000010163Gallus gallus
 Lgr5ENSMUSG00000020140Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LGR6 / Q9HBX8 / leucine rich repeat containing G protein-coupled receptor 6ENSG0000013306755
LGR4 / Q9BXB1 / leucine rich repeat containing G protein-coupled receptor 4ENSG0000020521348
LHCGR / P22888 / luteinizing hormone/choriogonadotropin receptorENSG0000013803919
TSHR / P16473 / thyroid stimulating hormone receptorENSG0000016540919
FSHR / P23945 / follicle stimulating hormone receptorENSG0000017082019
RXFP2 / Q8WXD0 / relaxin/insulin like family peptide receptor 2ENSG0000013310518
RXFP1 / Q9HBX9 / relaxin/insulin like family peptide receptor 1ENSG0000017150917
AC073082.1ENSG000002799566


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000372  Leucine-rich repeat N-terminal domain
 IPR001611  Leucine-rich repeat
 IPR002131  Glycoprotein hormone receptor family
 IPR003591  Leucine-rich repeat, typical subtype
 IPR017452  GPCR, rhodopsin-like, 7TM
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
anatomical structure developmentmolting cyclecell communicationcellular response to stimuluscellular developmental processmulticellular organism reproductionepithelial cell proliferationanatomical structure developmentmolting cyclecell communicationcellular response to stimuluscellular developmental processmulticellular organism reproductionepithelial cell proliferationanatomical structure developmentmolting cyclecell communicationcellular response to stimuluscellular developmental processmulticellular organism reproductionepithelial cell proliferationanatomical structure developmentmolting cyclecell communicationcellular response to stimuluscellular developmental processmulticellular organism reproductionepithelial cell proliferationanatomical structure developmentmolting cyclecell communicationcellular response to stimuluscellular developmental processmulticellular organism reproductionepithelial cell proliferationanatomical structure developmentmolting cyclecell communicationcellular response to stimuluscellular developmental processmulticellular organism reproductionepithelial cell proliferationanatomical structure developmentmolting cyclecell communicationcellular response to stimuluscellular developmental processmulticellular organism reproductionepithelial cell proliferationanatomical structure developmentmolting cyclecell communicationcellular response to stimuluscellular developmental processmulticellular organism reproductionepithelial cell proliferationanatomical structure developmentmolting cyclecell communicationcellular response to stimuluscellular developmental processmulticellular organism reproductionepithelial cell proliferationanatomical structure developmentmolting cyclecell communicationcellular response to stimuluscellular developmental processmulticellular organism reproductionepithelial cell proliferationanatomical structureanatomical structure developmentmolting cyclemolting cyclecell communicationcell communicationcellular response tocellular response to stimuluscellular developmentcellular developmental processmulticellular organimulticellular organism reproductionepithelial cell prolepithelial cell proliferation
signaling receptor activityprotein bindingsignaling receptor activityprotein bindingsignaling receptor activityprotein bindingsignaling receptor activityprotein bindingsignaling receptor activityprotein bindingsignaling receptor activityprotein bindingsignaling receptor activityprotein bindingsignaling receptor activityprotein bindingsignaling receptor activityprotein bindingsignaling receptor activityprotein bindingsignaling receptor activitysignaling receptor activityprotein bindingprotein binding
cellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellcellorganelleorganellemembranemembrane
TypeGO IDTermEv.Code
 biological_processGO:0001942 hair follicle development IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0009994 oocyte differentiation IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0048839 inner ear development IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IDA
 biological_processGO:2001013 epithelial cell proliferation involved in renal tubule morphogenesis IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032588 trans-Golgi network membrane IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IDA
 molecular_functionGO:0004930 G-protein coupled receptor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016500 protein-hormone receptor activity IEA


Pathways (from Reactome)
Pathway description
Regulation of FZD by ubiquitination


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000101282 RSPO4 / Q2I0M5 / R-spondin 4  / complex / reaction
 ENSG00000147655 RSPO2 / Q6UXX9 / R-spondin 2  / complex / reaction
 ENSG00000146374 RSPO3 / Q9BXY4 / R-spondin 3  / complex / reaction
 ENSG00000169218 RSPO1 / Q2MKA7 / R-spondin 1  / complex / reaction
 ENSG00000183579 ZNRF3 / Q9ULT6 / zinc and ring finger 3  / complex / reaction
 ENSG00000108375 RNF43 / Q68DV7 / ring finger protein 43  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr