Manteia

ENSG00000171509

Homo sapiens

Features

Gene ID:	ENSG00000171509

Biological name :	RXFP1

Synonyms :	Q9HBX9 / relaxin/insulin like family peptide receptor 1 / RXFP1

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	4
Strand:	1
Band:	q32.1
Gene start:	158315311
Gene end:	158653372

Corresponding Affymetrix probe sets:	1552715_a_at (Human Genome U133 Plus 2.0 Array) 231804_at (Human Genome U133 Plus 2.0 Array) 238206_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000414885 Ensembl peptide - ENSP00000405841 Ensembl peptide - ENSP00000420712 Ensembl peptide - ENSP00000480522 Ensembl peptide - ENSP00000434475 Ensembl peptide - ENSP00000432036 Ensembl peptide - ENSP00000423306 Ensembl peptide - ENSP00000303248 Ensembl peptide - ENSP00000345889 NCBI entrez gene - 59350 See in Manteia. OMIM - 606654 RefSeq - XM_017008526 RefSeq - XM_011532174 RefSeq - XM_011532175 RefSeq - XM_011532176 RefSeq - XM_011532179 RefSeq - XM_017008517 RefSeq - XM_017008518 RefSeq - XM_017008519 RefSeq - XM_017008520 RefSeq - XM_017008521 RefSeq - XM_017008522 RefSeq - XM_017008523 RefSeq - XM_017008524 RefSeq - XM_017008525 RefSeq - NM_001253727 RefSeq - NM_001253728 RefSeq - NM_001253729 RefSeq - NM_001253730 RefSeq - NM_001253732 RefSeq - NM_001253733 RefSeq - NM_021634 RefSeq Peptide - NP_001240657 RefSeq Peptide - NP_001240658 RefSeq Peptide - NP_001240659 RefSeq Peptide - NP_001240661 RefSeq Peptide - NP_001240662 RefSeq Peptide - NP_067647 RefSeq Peptide - NP_001240656 swissprot - E9PCA3 swissprot - B4DGP2 swissprot - A0A0A0MT52 swissprot - A0A087WWV0 swissprot - E9PIF0 swissprot - Q9HBX9 Ensembl - ENSG00000171509

See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
rxfp1	ENSDARG00000090071	Danio rerio
RXFP1	ENSGALG00000009429	Gallus gallus
Rxfp1	ENSMUSG00000034009	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
RXFP2 / Q8WXD0 / relaxin/insulin like family peptide receptor 2	ENSG00000133105	50
LGR5 / O75473 / leucine rich repeat containing G protein-coupled receptor 5	ENSG00000139292	20
LGR4 / Q9BXB1 / leucine rich repeat containing G protein-coupled receptor 4	ENSG00000205213	19
LGR6 / Q9HBX8 / leucine rich repeat containing G protein-coupled receptor 6	ENSG00000133067	18
LHCGR / P22888 / luteinizing hormone/choriogonadotropin receptor	ENSG00000138039	17
TSHR / P16473 / thyroid stimulating hormone receptor	ENSG00000165409	17
FSHR / P23945 / follicle stimulating hormone receptor	ENSG00000170820	17
AC073082.1	ENSG00000279956	5

Protein motifs (from Interpro)

Interpro ID	Name
IPR000276	G protein-coupled receptor, rhodopsin-like
IPR001611	Leucine-rich repeat
IPR002172	Low-density lipoprotein (LDL) receptor class A repeat
IPR003591	Leucine-rich repeat, typical subtype
IPR008112	Relaxin receptor
IPR017452	GPCR, rhodopsin-like, 7TM
IPR023415	Low-density lipoprotein (LDL) receptor class A, conserved site
IPR032675	Leucine-rich repeat domain superfamily
IPR036055	LDL receptor-like superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0007165	signal transduction	IEA
biological_process	GO:0007186	G-protein coupled receptor signaling pathway	IEA
biological_process	GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	IEA
biological_process	GO:0007567	parturition	IEA
biological_process	GO:0030154	cell differentiation	IEA
biological_process	GO:0030198	extracellular matrix organization	IEA
biological_process	GO:0060427	lung connective tissue development	IEA
biological_process	GO:0060658	nipple morphogenesis	IEA
cellular_component	GO:0005886	plasma membrane	IBA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
molecular_function	GO:0004871	obsolete signal transducer activity	IEA
molecular_function	GO:0004930	G-protein coupled receptor activity	IEA
molecular_function	GO:0005515	protein binding	IEA
molecular_function	GO:0042562	hormone binding	IEA
molecular_function	GO:0046872	metal ion binding	IEA

Pathways (from Reactome)

Pathway description

G alpha (s) signalling events

Relaxin receptors

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSG00000107014	RLN2 / P04090 / relaxin 2	/ complex / reaction
ENSG00000171136	RLN3 / Q8WXF3 / relaxin 3	/ complex / reaction

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr