ENSG00000139574


Homo sapiens

Features
Gene ID: ENSG00000139574
  
Biological name :NPFF
  
Synonyms : neuropeptide FF-amide peptide precursor / NPFF / O15130
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q13.13
Gene start: 53506690
Gene end: 53507638
  
Corresponding Affymetrix probe sets: 206402_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000267017
NCBI entrez gene - 8620     See in Manteia.
OMIM - 604643
RefSeq - NM_003717
RefSeq - NM_001320296
RefSeq Peptide - NP_001307225
RefSeq Peptide - NP_003708
swissprot - O15130
Ensembl - ENSG00000139574
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NpffENSMUSG00000023052Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR008065  Pro-FMRFamide-related neuropeptide FF


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002438 acute inflammatory response to antigenic stimulus IEA
 biological_processGO:0003254 regulation of membrane depolarization IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007218 neuropeptide signaling pathway TAS
 biological_processGO:0007268 chemical synaptic transmission TAS
 biological_processGO:0010459 negative regulation of heart rate IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0021510 spinal cord development IEA
 biological_processGO:0030103 vasopressin secretion IEA
 biological_processGO:0032099 negative regulation of appetite IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043278 response to morphine IEA
 biological_processGO:0045777 positive regulation of blood pressure IEA
 biological_processGO:0046676 negative regulation of insulin secretion IEA
 biological_processGO:0051930 regulation of sensory perception of pain IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0060135 maternal process involved in female pregnancy IEA
 biological_processGO:0070253 somatostatin secretion IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031982 vesicle IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0043679 axon terminus IEA
 cellular_componentGO:0098794 postsynapse IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IEA
 molecular_functionGO:0005102 signaling receptor binding TAS
 molecular_functionGO:0005184 neuropeptide hormone activity IBA


Pathways (from Reactome)
Pathway description
Orexin and neuropeptides FF and QRFP bind to their respective receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000148734 NPFFR1 / Q9GZQ6 / neuropeptide FF receptor 1  / complex / reaction
 ENSG00000056291 NPFFR2 / Q9Y5X5 / neuropeptide FF receptor 2  / complex / reaction






 

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