ENSG00000148734


Homo sapiens

Features
Gene ID: ENSG00000148734
  
Biological name :NPFFR1
  
Synonyms : neuropeptide FF receptor 1 / NPFFR1 / Q9GZQ6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: -1
Band: q22.1
Gene start: 70247329
Gene end: 70283676
  
Corresponding Affymetrix probe sets: 221387_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000277942
NCBI entrez gene - 64106     See in Manteia.
OMIM - 607448
RefSeq - NM_022146
RefSeq Peptide - NP_071429
swissprot - Q9GZQ6
Ensembl - ENSG00000148734
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 npffr1ENSDARG00000111997Danio rerio
 NPFFR1ENSGALG00000004446Gallus gallus
 Npffr1ENSMUSG00000020090Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NPFFR2 / Q9Y5X5 / neuropeptide FF receptor 2ENSG0000005629149
HCRTR1 / O43613 / hypocretin receptor 1ENSG0000012176430
HCRTR2 / O43614 / hypocretin receptor 2ENSG0000013725230
CCKAR / P32238 / cholecystokinin A receptorENSG0000016339426
QRFPR / Q96P65 / pyroglutamylated RFamide peptide receptorENSG0000018686724
CCKBR / P32239 / cholecystokinin B receptorENSG0000011014823
GALR3 / O60755 / galanin receptor 3ENSG0000012831023
GALR1 / P47211 / galanin receptor 1ENSG0000016657323
GALR2 / O43603 / galanin receptor 2ENSG0000018268723
KISS1R / Q969F8 / KISS1 receptorENSG0000011601422


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR005395  Neuropeptide FF receptor family
 IPR005396  Neuropeptide FF receptor, type 1
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007218 neuropeptide signaling pathway IEA
 biological_processGO:0008150 biological_process ND
 biological_processGO:0032870 cellular response to hormone stimulus IBA
 biological_processGO:1901652 response to peptide IBA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IBA
 molecular_functionGO:0008188 neuropeptide receptor activity NAS
 molecular_functionGO:0042277 peptide binding IBA


Pathways (from Reactome)
Pathway description
Orexin and neuropeptides FF and QRFP bind to their respective receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000139574 NPFF / O15130 / neuropeptide FF-amide peptide precursor  / complex / reaction






 

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