ENSG00000121764


Homo sapiens

Features
Gene ID: ENSG00000121764
  
Biological name :HCRTR1
  
Synonyms : HCRTR1 / hypocretin receptor 1 / O43613
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p35.2
Gene start: 31617686
Gene end: 31632518
  
Corresponding Affymetrix probe sets: 207619_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000384387
Ensembl peptide - ENSP00000362809
Ensembl peptide - ENSP00000362810
NCBI entrez gene - 3061     See in Manteia.
OMIM - 602392
RefSeq - XM_017001107
RefSeq - NM_001525
RefSeq - XM_017001105
RefSeq - XM_017001106
RefSeq Peptide - NP_001516
swissprot - A6NMV7
swissprot - O43613
Ensembl - ENSG00000121764
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Hcrtr1ENSMUSG00000028778Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HCRTR2 / O43614 / hypocretin receptor 2ENSG0000013725268
NPFFR1 / Q9GZQ6 / neuropeptide FF receptor 1ENSG0000014873431
NPFFR2 / Q9Y5X5 / neuropeptide FF receptor 2ENSG0000005629128
CCKBR / P32239 / cholecystokinin B receptorENSG0000011014825
KISS1R / Q969F8 / KISS1 receptorENSG0000011601423
CCKAR / P32238 / cholecystokinin A receptorENSG0000016339423
GALR1 / P47211 / galanin receptor 1ENSG0000016657322
QRFPR / Q96P65 / pyroglutamylated RFamide peptide receptorENSG0000018686722
GALR2 / O43603 / galanin receptor 2ENSG0000018268720
GALR3 / O60755 / galanin receptor 3ENSG0000012831018


Protein motifs (from Interpro)
Interpro ID Name
 IPR000204  Orexin receptor family
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR004059  Orexin receptor 1
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007218 neuropeptide signaling pathway IEA
 biological_processGO:0007268 chemical synaptic transmission TAS
 biological_processGO:0007631 feeding behavior IBA
 biological_processGO:0032870 cellular response to hormone stimulus IBA
 biological_processGO:0045187 regulation of circadian sleep/wake cycle, sleep IBA
 biological_processGO:0051480 regulation of cytosolic calcium ion concentration IDA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:1901652 response to peptide IBA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity TAS
 molecular_functionGO:0016499 orexin receptor activity IDA
 molecular_functionGO:0017046 peptide hormone binding IEA
 molecular_functionGO:0042277 peptide binding IBA


Pathways (from Reactome)
Pathway description
Orexin and neuropeptides FF and QRFP bind to their respective receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000161610 HCRT / O43612 / hypocretin neuropeptide precursor  / complex / reaction






 

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