ENSG00000142449


Homo sapiens

Features
Gene ID: ENSG00000142449
  
Biological name :FBN3
  
Synonyms : FBN3 / fibrillin 3 / Q75N90
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: p13.2
Gene start: 8065402
Gene end: 8149846
  
Corresponding Affymetrix probe sets: 240117_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000469256
Ensembl peptide - ENSP00000472324
Ensembl peptide - ENSP00000472729
Ensembl peptide - ENSP00000270509
Ensembl peptide - ENSP00000470498
NCBI entrez gene - 84467     See in Manteia.
OMIM - 608529
RefSeq - XM_017027379
RefSeq - XM_017027373
RefSeq - XM_017027374
RefSeq - XM_017027375
RefSeq - XM_017027376
RefSeq - XM_017027377
RefSeq - NM_001321431
RefSeq - NM_032447
RefSeq - XM_017027372
RefSeq Peptide - NP_001308360
RefSeq Peptide - NP_115823
swissprot - M0R2Q5
swissprot - Q75N90
swissprot - M0QXL8
Ensembl - ENSG00000142449
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
No match


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FBN2 / P35556 / fibrillin 2ENSG0000013882968
FBN1 / P35555 / fibrillin 1ENSG0000016614760
LTBP2 / Q14767 / latent transforming growth factor beta binding protein 2ENSG0000011968118
LTBP1 / Q14766 / latent transforming growth factor beta binding protein 1ENSG0000004932317
LTBP4 / Q8N2S1 / latent transforming growth factor beta binding protein 4ENSG0000009000617
LTBP3 / Q9NS15 / latent transforming growth factor beta binding protein 3ENSG0000016805613
FBLN2 / P98095 / fibulin 2ENSG0000016352011
FBLN1 / P23142 / fibulin 1ENSG000000779427
EFEMP1 / Q12805 / EGF containing fibulin extracellular matrix protein 1ENSG000001153804
FBLN5 / Q9UBX5 / fibulin 5ENSG000001400924
EFEMP2 / O95967 / EGF containing fibulin extracellular matrix protein 2ENSG000001726384


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR001881  EGF-like calcium-binding domain
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR013032  EGF-like, conserved site
 IPR017878  TB domain
 IPR018097  EGF-like calcium-binding, conserved site
 IPR026823  Complement Clr-like EGF domain
 IPR036773  TGF-beta binding (TB) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009653 anatomical structure morphogenesis IBA
 biological_processGO:0090287 regulation of cellular response to growth factor stimulus IBA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0031012 extracellular matrix IBA
 molecular_functionGO:0005201 extracellular matrix structural constituent IEA
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix
Elastic fibre formation
Molecules associated with elastic fibres


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000142449 FBN3 / Q75N90 / fibrillin 3  / -






 

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