ENSG00000142945


Homo sapiens

Features
Gene ID: ENSG00000142945
  
Biological name :KIF2C
  
Synonyms : KIF2C / kinesin family member 2C / Q99661
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p34.1
Gene start: 44739818
Gene end: 44767767
  
Corresponding Affymetrix probe sets: 209408_at (Human Genome U133 Plus 2.0 Array)   211519_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000361291
Ensembl peptide - ENSP00000395050
Ensembl peptide - ENSP00000402172
Ensembl peptide - ENSP00000410346
Ensembl peptide - ENSP00000361298
NCBI entrez gene - 11004     See in Manteia.
OMIM - 604538
RefSeq - XM_011540541
RefSeq - NM_001297655
RefSeq - NM_001297656
RefSeq - NM_001297657
RefSeq - NM_006845
RefSeq - XM_011540540
RefSeq Peptide - NP_001284584
RefSeq Peptide - NP_001284585
RefSeq Peptide - NP_001284586
RefSeq Peptide - NP_006836
swissprot - H0Y5Z9
swissprot - Q5JR89
swissprot - Q5JR91
swissprot - Q99661
swissprot - A0A140VKF1
Ensembl - ENSG00000142945
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kif2cENSDARG00000076228Danio rerio
 ENSGALG00000010120Gallus gallus
 Kif2cENSMUSG00000028678Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KIF2A / O00139 / kinesin family member 2AENSG0000006879654
KIF2B / Q8N4N8 / kinesin family member 2BENSG0000014120043
KIF24 / Q5T7B8 / kinesin family member 24ENSG0000018663832
KIF18A / Q8NI77 / kinesin family member 18AENSG0000012162120
KIF23 / Q02241 / kinesin family member 23ENSG0000013780719
KIF20B / Q96Q89 / kinesin family member 20BENSG0000013818219
KIF18B / Q86Y91 / kinesin family member 18BENSG0000018618519
KIF19 / Q2TAC6 / kinesin family member 19ENSG0000019616919
KIF22 / Q14807 / kinesin family member 22ENSG0000007961616
KIF20A / O95235 / kinesin family member 20AENSG0000011298416


Protein motifs (from Interpro)
Interpro ID Name
 IPR001752  Kinesin motor domain
 IPR019821  Kinesin motor domain, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR027640  Kinesin-like protein
 IPR036961  Kinesin motor domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000278 mitotic cell cycle TAS
 biological_processGO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS
 biological_processGO:0007018 microtubule-based movement IEA
 biological_processGO:0007019 microtubule depolymerization IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007059 chromosome segregation IEA
 biological_processGO:0007062 sister chromatid cohesion TAS
 biological_processGO:0007080 mitotic metaphase plate congression IMP
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
 biological_processGO:0030951 establishment or maintenance of microtubule cytoskeleton polarity IMP
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051310 metaphase plate congression IMP
 biological_processGO:0051315 attachment of mitotic spindle microtubules to kinetochore IMP
 biological_processGO:0051983 regulation of chromosome segregation IMP
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005871 kinesin complex TAS
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005881 cytoplasmic microtubule ISS
 cellular_componentGO:0015630 microtubule cytoskeleton IDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0035371 microtubule plus-end TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0003777 microtubule motor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0016887 ATPase activity IBA
 molecular_functionGO:0019237 centromeric DNA binding TAS
 molecular_functionGO:0051010 microtubule plus-end binding IDA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
MHC class II antigen presentation
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
COPI-dependent Golgi-to-ER retrograde traffic
Mitotic Prometaphase
Kinesins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000141200 KIF2B / Q8N4N8 / kinesin family member 2B  / reaction
 ENSG00000142945 KIF2C / Q99661 / kinesin family member 2C  / complex / reaction
 ENSG00000068796 KIF2A / O00139 / kinesin family member 2A  / reaction






 

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