ENSG00000143198


Homo sapiens
MGST3membraneprocessactivityeicosanoidproteinmetabolicbiosyntheticdetoxificationendoplasmicreticulumorganelletransferasemembrane-associatedmetabolismmapegassociatedmetabolism-likedomainsuperfamilylipidxenobioticresponseorganonitrogencompoundleukotrienecellularoxidantderivativenuclear

Features
Gene ID: ENSG00000143198
  
Biological name :MGST3
  
Synonyms : MGST3 / microsomal glutathione S-transferase 3 / O14880
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q24.1
Gene start: 165630861
Gene end: 165661796
  
Corresponding Affymetrix probe sets: 201403_s_at (Human Genome U133 Plus 2.0 Array)   233307_x_at (Human Genome U133 Plus 2.0 Array)   244122_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000356863
Ensembl peptide - ENSP00000487151
Ensembl peptide - ENSP00000356864
Ensembl peptide - ENSP00000356858
Ensembl peptide - ENSP00000356859
Ensembl peptide - ENSP00000356860
NCBI entrez gene - 4259     See in Manteia.
OMIM - 604564
RefSeq - NM_004528
RefSeq - XM_005245174
RefSeq Peptide - NP_004519
swissprot - O14880
swissprot - A0A024R8Z1
swissprot - Q5VV87
swissprot - Q5VV89
Ensembl - ENSG00000143198
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mgst3aENSDARG00000102744Danio rerio
 MGST3ENSGALG00000003445Gallus gallus
 Mgst3ENSMUSG00000026688Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001129  Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein
 IPR023352  Membrane associated eicosanoid/glutathione metabolism-like domain superfamily


Gene Ontology (GO)
primary metabolic processorganic substance metabolic processresponse to chemicalcellular metabolic processcellular response to stimulusbiosynthetic processsmall molecule metabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processresponse to chemicalcellular metabolic processcellular response to stimulusbiosynthetic processsmall molecule metabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processresponse to chemicalcellular metabolic processcellular response to stimulusbiosynthetic processsmall molecule metabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processresponse to chemicalcellular metabolic processcellular response to stimulusbiosynthetic processsmall molecule metabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processresponse to chemicalcellular metabolic processcellular response to stimulusbiosynthetic processsmall molecule metabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processresponse to chemicalcellular metabolic processcellular response to stimulusbiosynthetic processsmall molecule metabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processresponse to chemicalcellular metabolic processcellular response to stimulusbiosynthetic processsmall molecule metabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processresponse to chemicalcellular metabolic processcellular response to stimulusbiosynthetic processsmall molecule metabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processresponse to chemicalcellular metabolic processcellular response to stimulusbiosynthetic processsmall molecule metabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processresponse to chemicalcellular metabolic processcellular response to stimulusbiosynthetic processsmall molecule metabolic processnitrogen compound metabolic processprimary metabolicprimary metabolic processorganic substanceorganic substance metabolic processresponse to chemiresponse to chemicalcellular metabolicellular metabolic processcellular responsecellular response to stimulusbiosynthetic procbiosynthetic processsmall molecule mesmall molecule metabolic processnitrogen compoundnitrogen compound metabolic process
transferase activitylyase activityoxidoreductase activityprotein bindingtransferase activitylyase activityoxidoreductase activityprotein bindingtransferase activitylyase activityoxidoreductase activityprotein bindingtransferase activitylyase activityoxidoreductase activityprotein bindingtransferase activitylyase activityoxidoreductase activityprotein bindingtransferase activitylyase activityoxidoreductase activityprotein bindingtransferase activitylyase activityoxidoreductase activityprotein bindingtransferase activitylyase activityoxidoreductase activityprotein bindingtransferase activitylyase activityoxidoreductase activityprotein bindingtransferase activitylyase activityoxidoreductase activityprotein bindingtransferase activitytransferase activitylyase activitylyase activityoxidoreductase activityoxidoreductase activityprotein bindingprotein binding
cellorganellemembraneextracellular regioncellorganellemembraneextracellular regioncellorganellemembraneextracellular regioncellorganellemembraneextracellular regioncellorganellemembraneextracellular regioncellorganellemembraneextracellular regioncellorganellemembraneextracellular regioncellorganellemembraneextracellular regioncellorganellemembraneextracellular regioncellorganellemembraneextracellular regioncellcellorganelleorganellemembranemembraneextracellular regionextracellular region
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IDA
 biological_processGO:0006805 xenobiotic metabolic process TAS
 biological_processGO:0010243 response to organonitrogen compound IEA
 biological_processGO:0019370 leukotriene biosynthetic process IDA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 biological_processGO:1901687 glutathione derivative biosynthetic process TAS
 cellular_componentGO:0005635 nuclear envelope IBA
 cellular_componentGO:0005783 endoplasmic reticulum IBA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004364 glutathione transferase activity TAS
 molecular_functionGO:0004464 leukotriene-C4 synthase activity IDA
 molecular_functionGO:0004602 glutathione peroxidase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Glutathione conjugation
Aflatoxin activation and detoxification


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000143198 MGST3 / O14880 / microsomal glutathione S-transferase 3  / complex






 

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