ENSG00000144161


Homo sapiens

Features
Gene ID: ENSG00000144161
  
Biological name :ZC3H8
  
Synonyms : Q8N5P1 / ZC3H8 / zinc finger CCCH-type containing 8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: q14.1
Gene start: 112211525
Gene end: 112255136
  
Corresponding Affymetrix probe sets: 223506_at (Human Genome U133 Plus 2.0 Array)   239644_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000483976
Ensembl peptide - ENSP00000272570
Ensembl peptide - ENSP00000386488
NCBI entrez gene - 84524     See in Manteia.
RefSeq - XM_017005107
RefSeq - NM_032494
RefSeq - XM_011511998
RefSeq Peptide - NP_115883
swissprot - Q8N5P1
swissprot - A0A0C4DGZ1
Ensembl - ENSG00000144161
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ZC3H6ENSGALG00000008269Gallus gallus
 Zc3h8ENSMUSG00000027387Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ZC3H6 / P61129 / zinc finger CCCH-type containing 6ENSG0000018817747
ZC3H4 / Q9UPT8 / zinc finger CCCH-type containing 4ENSG0000013074933


Protein motifs (from Interpro)
Interpro ID Name
 IPR000571  Zinc finger, CCCH-type
 IPR036855  Zinc finger, CCCH-type superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0033085 negative regulation of T cell differentiation in thymus IMP
 biological_processGO:0042795 snRNA transcription by RNA polymerase II TAS
 biological_processGO:0042796 snRNA transcription by RNA polymerase III IMP
 biological_processGO:0043029 T cell homeostasis IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISS
 biological_processGO:0045945 positive regulation of transcription by RNA polymerase III IMP
 biological_processGO:0046677 response to antibiotic IDA
 biological_processGO:0070245 positive regulation of thymocyte apoptotic process IMP
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0008023 transcription elongation factor complex IDA
 cellular_componentGO:0015030 Cajal body IDA
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0035327 transcriptionally active chromatin IDA
 cellular_componentGO:0035363 histone locus body IDA
 molecular_functionGO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IMP
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding ISS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
RNA polymerase II transcribes snRNA genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000118985 ELL2 / O00472 / elongation factor for RNA polymerase II 2  / complex
 ENSG00000105656 ELL / P55199 / elongation factor for RNA polymerase II  / complex
 ENSG00000128915 ICE2 / Q659A1 / interactor of little elongation complex ELL subunit 2  / complex
 ENSG00000164151 ICE1 / Q9Y2F5 / interactor of little elongation complex ELL subunit 1  / complex
 ENSG00000128886 ELL3 / Q9HB65 / elongation factor for RNA polymerase II 3  / complex






 

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