ENSMUSG00000027387


Mus musculus
transcriptionZc3h8rnapolymeraseregulationiibindingdna-templatedsnrnabodysequence-specificdnazincfingerccch-typeapoptoticprocesstcelliiifactorregulatoryregionactivitysuperfamilydifferentiationthymushomeostasisresponseantibioticthymocyte

Features
Gene ID: ENSMUSG00000027387
  
Biological name :Zc3h8
  
Synonyms : Q9JJ48 / Zc3h8 / zinc finger CCCH type containing 8
  
Possible biological names infered from orthology : Q8N5P1
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: F1
Gene start: 128926268
Gene end: 128944077
  
Corresponding Affymetrix probe sets: 10487564 (MoGene1.0st)   1418495_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028866
NCBI entrez gene - 57432     See in Manteia.
MGI - MGI:1930128
RefSeq - NM_020594
RefSeq - XM_006499947
RefSeq Peptide - NP_065619
swissprot - Q9JJ48
Ensembl - ENSMUSG00000027387
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ZC3H6ENSGALG00000008269Gallus gallus
 ZC3H8ENSG00000144161Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Zc3h6 / Q8BYK8 / zinc finger CCCH type containing 6 / P61129*ENSMUSG0000004285140
Zc3h4 / zinc finger CCCH-type containing 4 / Q9UPT8*ENSMUSG0000005927330


Protein motifs (from Interpro)
Interpro ID Name
 IPR000571  Zinc finger, CCCH-type
 IPR036855  Zinc finger, CCCH-type superfamily


Gene Ontology (GO)
nitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell deathanatomical structure developmentcellular developmental processcell activationcell adhesionregulation of biological qualityresponse to chemicalnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell deathanatomical structure developmentcellular developmental processcell activationcell adhesionregulation of biological qualityresponse to chemicalnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell deathanatomical structure developmentcellular developmental processcell activationcell adhesionregulation of biological qualityresponse to chemicalnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell deathanatomical structure developmentcellular developmental processcell activationcell adhesionregulation of biological qualityresponse to chemicalnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell deathanatomical structure developmentcellular developmental processcell activationcell adhesionregulation of biological qualityresponse to chemicalnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell deathanatomical structure developmentcellular developmental processcell activationcell adhesionregulation of biological qualityresponse to chemicalnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell deathanatomical structure developmentcellular developmental processcell activationcell adhesionregulation of biological qualityresponse to chemicalnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell deathanatomical structure developmentcellular developmental processcell activationcell adhesionregulation of biological qualityresponse to chemicalnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell deathanatomical structure developmentcellular developmental processcell activationcell adhesionregulation of biological qualityresponse to chemicalnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell deathanatomical structure developmentcellular developmental processcell activationcell adhesionregulation of biological qualityresponse to chemicalnitrogen conitrogen compound metabolic processbiosynthetibiosynthetic processcellular mecellular metabolic processprimary metprimary metabolic processorganic suborganic substance metabolic processcell deathcell deathanatomical anatomical structure developmentcellular decellular developmental processcell activacell activationcell adhesicell adhesionregulation regulation of biological qualityresponse toresponse to chemical
organic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityion bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityion bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityion bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityion bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityion bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityion bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityion bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityion bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityion bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityion bindingorganic cyclic compound bindingorganic cyclic compound bindingheterocyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor acDNA-binding transcription factor activityion bindingion binding
cellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellcellorganelleorganellemembrane-enclosed lumenmembrane-enclosed lumenprotein-containing complexprotein-containing complex
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0033085 negative regulation of T cell differentiation in thymus IEA
 biological_processGO:0042795 snRNA transcription by RNA polymerase II IEA
 biological_processGO:0042796 snRNA transcription by RNA polymerase III IEA
 biological_processGO:0043029 T cell homeostasis IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045945 positive regulation of transcription by RNA polymerase III IEA
 biological_processGO:0046677 response to antibiotic IEA
 biological_processGO:0070245 positive regulation of thymocyte apoptotic process IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0008023 transcription elongation factor complex IEA
 cellular_componentGO:0015030 Cajal body IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0035327 transcriptionally active chromatin IEA
 cellular_componentGO:0035363 histone locus body IEA
 molecular_functionGO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
RNA polymerase II transcribes snRNA genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001542 Ell2 / Q3UKU1 / RNA polymerase II elongation factor ELL2 / O00472* / elongation factor for RNA polymerase II 2*  / complex
 ENSMUSG00000034525 Ice1 / E9Q286 / Little elongation complex subunit 1 / Q9Y2F5* / interactor of little elongation complex ELL subunit 1*  / complex
 ENSMUSG00000027246 Ell3 / Q80VR2 / RNA polymerase II elongation factor ELL3 / Q9HB65* / elongation factor for RNA polymerase II 3*  / complex
 ENSMUSG00000070002 Ell / O08856 / RNA polymerase II elongation factor ELL / P55199* / elongation factor for RNA polymerase II*  / complex
 ENSMUSG00000032235 Ice2 / Q3UZ18 / Little elongation complex subunit 2 / Q659A1* / interactor of little elongation complex ELL subunit 2*  / complex






 

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