ENSG00000144283


Homo sapiens

Features
Gene ID: ENSG00000144283
  
Biological name :PKP4
  
Synonyms : PKP4 / plakophilin 4 / Q99569
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q24.1
Gene start: 158456964
Gene end: 158682879
  
Corresponding Affymetrix probe sets: 201927_s_at (Human Genome U133 Plus 2.0 Array)   201928_at (Human Genome U133 Plus 2.0 Array)   201929_s_at (Human Genome U133 Plus 2.0 Array)   214874_at (Human Genome U133 Plus 2.0 Array)   236752_at (Human Genome U133 Plus 2.0 Array)   240379_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000393872
Ensembl peptide - ENSP00000392515
Ensembl peptide - ENSP00000396827
Ensembl peptide - ENSP00000486877
Ensembl peptide - ENSP00000486320
Ensembl peptide - ENSP00000437815
Ensembl peptide - ENSP00000407218
Ensembl peptide - ENSP00000374407
Ensembl peptide - ENSP00000374409
Ensembl peptide - ENSP00000391658
NCBI entrez gene - 8502     See in Manteia.
OMIM - 604276
RefSeq - XM_017005135
RefSeq - XM_017005123
RefSeq - XM_017005124
RefSeq - XM_017005125
RefSeq - XM_017005126
RefSeq - XM_017005127
RefSeq - XM_017005128
RefSeq - XM_017005129
RefSeq - XM_017005130
RefSeq - XM_017005131
RefSeq - XM_017005132
RefSeq - XM_017005133
RefSeq - XM_017005134
RefSeq - NM_001005476
RefSeq - NM_001304969
RefSeq - NM_001304970
RefSeq - NM_001304971
RefSeq - NM_003628
RefSeq - XM_011512016
RefSeq - XM_011512017
RefSeq - XM_011512018
RefSeq - XM_011512019
RefSeq - XM_011512020
RefSeq - XM_011512021
RefSeq - XM_011512022
RefSeq - XM_011512025
RefSeq - XM_011512026
RefSeq - XM_017005122
RefSeq Peptide - NP_001291898
RefSeq Peptide - NP_001291899
RefSeq Peptide - NP_001291900
RefSeq Peptide - NP_003619
RefSeq Peptide - NP_001005476
swissprot - Q99569
swissprot - A0A0D9SF60
swissprot - E9PHJ1
swissprot - E7EST6
swissprot - E7EP40
swissprot - E7EMY7
swissprot - H0YFB1
Ensembl - ENSG00000144283
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pkp4ENSDARG00000045331Danio rerio
 PKP4ENSGALG00000012561Gallus gallus
 Pkp4ENSMUSG00000026991Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CTNND2 / Q9UQB3 / catenin delta 2ENSG0000016986251
ARVCF / O00192 / ARVCF, delta catenin family memberENSG0000009988930
CTNND1 / O60716 / catenin delta 1ENSG0000019856128
PKP2 / Q99959 / plakophilin 2ENSG0000005729418
PKP3 / Q9Y446 / plakophilin 3ENSG0000018436317
PKP1 / Q13835 / plakophilin 1ENSG0000008127716


Protein motifs (from Interpro)
Interpro ID Name
 IPR000225  Armadillo
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR028435  Plakophilin/Delta catenin
 IPR028443  Plakophilin-4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007043 cell-cell junction assembly IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007267 cell-cell signaling NAS
 biological_processGO:0030155 regulation of cell adhesion NAS
 biological_processGO:0031424 keratinization TAS
 biological_processGO:0032467 positive regulation of cytokinesis IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0070268 cornification TAS
 biological_processGO:0098609 cell-cell adhesion IEA
 cellular_componentGO:0000922 spindle pole IDA
 cellular_componentGO:0001533 cornified envelope TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0009898 cytoplasmic side of plasma membrane IDA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IDA
 cellular_componentGO:0030057 desmosome IEA
 cellular_componentGO:0030496 midbody IEA
 cellular_componentGO:0044291 cell-cell contact zone IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0051233 spindle midzone IDA
 cellular_componentGO:0072686 mitotic spindle IDA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Keratinization
Formation of the cornified envelope


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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