Manteia

ENSG00000184363

Homo sapiens

Features

Gene ID:	ENSG00000184363

Biological name :	PKP3

Synonyms :	PKP3 / plakophilin 3 / Q9Y446

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	11
Strand:	1
Band:	p15.5
Gene start:	392614
Gene end:	404908

Corresponding Affymetrix probe sets:	209872_s_at (Human Genome U133 Plus 2.0 Array) 209873_s_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000331678 Ensembl peptide - ENSP00000436847 Ensembl peptide - ENSP00000435522 Ensembl peptide - ENSP00000435478 Ensembl peptide - ENSP00000435383 Ensembl peptide - ENSP00000434517 Ensembl peptide - ENSP00000434110 NCBI entrez gene - 11187 See in Manteia. OMIM - 605561 RefSeq - NM_001303029 RefSeq - NM_007183 RefSeq Peptide - NP_001289958 RefSeq Peptide - NP_009114 swissprot - H0YEY5 swissprot - E9PRW6 swissprot - Q9Y446 swissprot - E9PQ15 swissprot - E9PKC4 swissprot - E9PK71 swissprot - E9PJR7 Ensembl - ENSG00000184363

See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
pkp3a	ENSDARG00000051861	Danio rerio
pkp3b	ENSDARG00000079438	Danio rerio
PKP3	ENSGALG00000004260	Gallus gallus
Pkp3	ENSMUSG00000054065	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
PKP2 / Q99959 / plakophilin 2	ENSG00000057294	28
PKP1 / Q13835 / plakophilin 1	ENSG00000081277	27
CTNND2 / Q9UQB3 / catenin delta 2	ENSG00000169862	26
ARVCF / O00192 / ARVCF, delta catenin family member	ENSG00000099889	25
PKP4 / Q99569 / plakophilin 4	ENSG00000144283	25
CTNND1 / O60716 / catenin delta 1	ENSG00000198561	23

Protein motifs (from Interpro)

Interpro ID	Name
IPR000225	Armadillo
IPR011989	Armadillo-like helical
IPR016024	Armadillo-type fold
IPR028434	Plakophilin-3
IPR028435	Plakophilin/Delta catenin

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0002159	desmosome assembly	IMP
biological_process	GO:0007155	cell adhesion	IEA
biological_process	GO:0010628	positive regulation of gene expression	IMP
biological_process	GO:0031424	keratinization	TAS
biological_process	GO:0070268	cornification	TAS
biological_process	GO:0072659	protein localization to plasma membrane	IMP
biological_process	GO:0098609	cell-cell adhesion	IEA
biological_process	GO:1902373	negative regulation of mRNA catabolic process	IMP
cellular_component	GO:0001533	cornified envelope	TAS
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005654	nucleoplasm	IDA
cellular_component	GO:0005886	plasma membrane	TAS
cellular_component	GO:0005911	cell-cell junction	TAS
cellular_component	GO:0005913	cell-cell adherens junction	IDA
cellular_component	GO:0030054	cell junction	IEA
cellular_component	GO:0030057	desmosome	IEA
cellular_component	GO:1990124	messenger ribonucleoprotein complex	IDA
molecular_function	GO:0005488	binding	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0019899	enzyme binding	IPI
molecular_function	GO:0045294	alpha-catenin binding	IPI
molecular_function	GO:0050839	cell adhesion molecule binding	IPI
molecular_function	GO:0098641	cadherin binding involved in cell-cell adhesion	IDA

Pathways (from Reactome)

Pathway description

Keratinization

Formation of the cornified envelope

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr