ENSG00000145996


Homo sapiens

Features
Gene ID: ENSG00000145996
  
Biological name :CDKAL1
  
Synonyms : CDK5 regulatory subunit associated protein 1 like 1 / CDKAL1 / Q5VV42
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: p22.3
Gene start: 20534457
Gene end: 21232404
  
Corresponding Affymetrix probe sets: 214877_at (Human Genome U133 Plus 2.0 Array)   220039_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000274695
Ensembl peptide - ENSP00000367873
Ensembl peptide - ENSP00000481755
NCBI entrez gene - 54901     See in Manteia.
OMIM - 611259
RefSeq - XM_017010987
RefSeq - NM_017774
RefSeq - XM_011514719
RefSeq - XM_017010986
RefSeq - XM_011514718
RefSeq Peptide - NP_060244
swissprot - Q5VV42
Ensembl - ENSG00000145996
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01090785.1ENSDARG00000110572Danio rerio
 cdkal1ENSDARG00000104848Danio rerio
 CDKAL1ENSGALG00000012677Gallus gallus
 Cdkal1ENSMUSG00000006191Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q96SZ6 / CDK5RAP1 / CDK5 regulatory subunit associated protein 1ENSG0000010139121


Protein motifs (from Interpro)
Interpro ID Name
 IPR002792  TRAM domain
 IPR005839  Methylthiotransferase
 IPR006466  MiaB-like tRNA modifying enzyme, archaeal-type
 IPR006638  Elp3/MiaB/NifB
 IPR007197  Radical SAM
 IPR013848  Methylthiotransferase, N-terminal
 IPR020612  Methylthiotransferase, conserved site
 IPR023404  Radical SAM, alpha/beta horseshoe


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006400 tRNA modification TAS
 biological_processGO:0008033 tRNA processing IEA
 biological_processGO:0008150 biological_process ND
 biological_processGO:0035600 tRNA methylthiolation IEA
 biological_processGO:1990145 maintenance of translational fidelity IEA
 cellular_componentGO:0005783 endoplasmic reticulum IBA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005791 rough endoplasmic reticulum IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0035598 N6-threonylcarbomyladenosine methylthiotransferase activity EXP
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051536 iron-sulfur cluster binding IEA
 molecular_functionGO:0051539 4 iron, 4 sulfur cluster binding IEA
 molecular_functionGO:0061712 tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase IEA


Pathways (from Reactome)
Pathway description
tRNA modification in the nucleus and cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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