ENSG00000148200


Homo sapiens
NR6A1hormonernapolymeraseiibindingactivitynuclearreceptordnasequence-specificzincregulationpromotersteroidfactordomainfingerdna-templatedsignalingpathwayproximalionligand-bindingreceptor-typenhrgata-typereceptor-likesuperfamilyinitiation

Features
Gene ID: ENSG00000148200
  
Biological name :NR6A1
  
Synonyms : NR6A1 / nuclear receptor subfamily 6 group A member 1 / Q15406
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: -1
Band: q33.3
Gene start: 124517275
Gene end: 124771310
  
Corresponding Affymetrix probe sets: 207742_s_at (Human Genome U133 Plus 2.0 Array)   210391_at (Human Genome U133 Plus 2.0 Array)   210392_x_at (Human Genome U133 Plus 2.0 Array)   211402_x_at (Human Genome U133 Plus 2.0 Array)   227494_at (Human Genome U133 Plus 2.0 Array)   227496_at (Human Genome U133 Plus 2.0 Array)   228894_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000341135
Ensembl peptide - ENSP00000413701
Ensembl peptide - ENSP00000420267
Ensembl peptide - ENSP00000420587
Ensembl peptide - ENSP00000362686
NCBI entrez gene - 2649     See in Manteia.
OMIM - 602778
RefSeq - XM_005251918
RefSeq - NM_001278546
RefSeq - NM_001489
RefSeq - NM_033334
RefSeq - XM_005251917
RefSeq Peptide - NP_001480
RefSeq Peptide - NP_201591
RefSeq Peptide - NP_001265475
swissprot - Q15406
swissprot - F1D8S0
swissprot - C9JDI9
swissprot - F1DAM1
Ensembl - ENSG00000148200
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nr6a1aENSDARG00000101508Danio rerio
 NR6A1ENSGALG00000001073Gallus gallus
 Nr6a1ENSMUSG00000063972Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NR5A2 / O00482 / nuclear receptor subfamily 5 group A member 2ENSG0000011683322
NR1D2 / Q14995 / nuclear receptor subfamily 1 group D member 2ENSG0000017473822
NR1D1 / P20393 / nuclear receptor subfamily 1 group D member 1ENSG0000012636821
RORC / P51449 / RAR related orphan receptor CENSG0000014336519
RORA / P35398 / RAR related orphan receptor AENSG0000006966718
NR5A1 / Q13285 / nuclear receptor subfamily 5 group A member 1ENSG0000013693118
PPARA / Q07869 / peroxisome proliferator activated receptor alphaENSG0000018695118
PPARD / Q03181 / peroxisome proliferator activated receptor deltaENSG0000011203317
PPARG / P37231 / peroxisome proliferator activated receptor gammaENSG0000013217017
RORB / Q92753 / RAR related orphan receptor BENSG0000019896317


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR013088  Zinc finger, NHR/GATA-type
 IPR035500  Nuclear hormone receptor-like domain superfamily


Gene Ontology (GO)
nitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processmulticellular organism reproductioncell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processmulticellular organism reproductioncell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processmulticellular organism reproductioncell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processmulticellular organism reproductioncell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processmulticellular organism reproductioncell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processmulticellular organism reproductioncell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processmulticellular organism reproductioncell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processmulticellular organism reproductioncell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processmulticellular organism reproductioncell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processmulticellular organism reproductioncell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusnitrogen componitrogen compound metabolic processbiosynthetic pbiosynthetic processcellular metabcellular metabolic processprimary metaboprimary metabolic processorganic substaorganic substance metabolic processmulticellular multicellular organism reproductioncell communicacell communicationresponse to enresponse to endogenous stimulusresponse to chresponse to chemicalcellular respocellular response to stimulus
organic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitysignaling receptor activityion bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitysignaling receptor activityion bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitysignaling receptor activityion bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitysignaling receptor activityion bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitysignaling receptor activityion bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitysignaling receptor activityion bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitysignaling receptor activityion bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitysignaling receptor activityion bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitysignaling receptor activityion bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitysignaling receptor activityion bindingprotein bindingorganic cyclic compoundorganic cyclic compound bindingheterocyclic compound bheterocyclic compound bindingDNA-binding transcriptiDNA-binding transcription factor activitysignaling receptor actisignaling receptor activityion bindingion bindingprotein bindingprotein binding
cellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellcellorganelleorganellemembrane-enclosed lumenmembrane-enclosed lumenprotein-containing complexprotein-containing complex
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter TAS
 biological_processGO:0007276 gamete generation ISS
 biological_processGO:0007283 spermatogenesis TAS
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0030518 intracellular steroid hormone receptor signaling pathway IBA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex ISS
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0004879 nuclear receptor activity TAS
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0042803 protein homodimerization activity ISS
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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