ENSG00000153147


Homo sapiens

Features
Gene ID: ENSG00000153147
  
Biological name :SMARCA5
  
Synonyms : O60264 / SMARCA5 / SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: q31.21
Gene start: 143513463
Gene end: 143557486
  
Corresponding Affymetrix probe sets: 202303_x_at (Human Genome U133 Plus 2.0 Array)   213251_at (Human Genome U133 Plus 2.0 Array)   213859_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000283131
NCBI entrez gene - 8467     See in Manteia.
OMIM - 603375
RefSeq - NM_003601
RefSeq Peptide - NP_003592
swissprot - O60264
Ensembl - ENSG00000153147
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SMARCA5ENSGALG00000009913Gallus gallus
 Q91ZW3ENSMUSG00000031715Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P28370 / SMARCA1 / SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1ENSG0000010203880
CHD1L / Q86WJ1 / chromodomain helicase DNA binding protein 1 likeENSG0000013177827


Protein motifs (from Interpro)
Interpro ID Name
 IPR000330  SNF2-related, N-terminal domain
 IPR001005  SANT/Myb domain
 IPR001650  Helicase, C-terminal
 IPR009057  Homeobox-like domain superfamily
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR015194  ISWI, HAND domain
 IPR015195  SLIDE domain
 IPR017884  SANT domain
 IPR020838  DBINO domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR029915  ISWI family
 IPR036306  ISWI, HAND domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000183 chromatin silencing at rDNA IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006333 chromatin assembly or disassembly IEA
 biological_processGO:0006334 nucleosome assembly IDA
 biological_processGO:0006338 chromatin remodeling TAS
 biological_processGO:0006352 DNA-templated transcription, initiation IDA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II TAS
 biological_processGO:0016584 nucleosome positioning IDA
 biological_processGO:0034080 CENP-A containing nucleosome assembly TAS
 biological_processGO:0043044 ATP-dependent chromatin remodeling IMP
 biological_processGO:0045815 positive regulation of gene expression, epigenetic TAS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEA
 cellular_componentGO:0000793 condensed chromosome IDA
 cellular_componentGO:0001650 fibrillar center IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005677 chromatin silencing complex IEA
 cellular_componentGO:0016589 NURF complex IDA
 cellular_componentGO:0031010 ISWI-type complex IEA
 cellular_componentGO:0031213 RSF complex IPI
 cellular_componentGO:0043596 nuclear replication fork IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0004386 helicase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEA
 molecular_functionGO:0016887 ATPase activity IDA
 molecular_functionGO:0031491 nucleosome binding IEA
 molecular_functionGO:0042393 histone binding IDA


Pathways (from Reactome)
Pathway description
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Deposition of new CENPA-containing nucleosomes at the centromere


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000115163 CENPA / P49450 / centromere protein A  / complex
 ENSG00000168148 Q16695 / HIST3H3 / histone cluster 3 H3  / reaction
 ENSG00000188486 H2AFX / P16104 / H2A histone family member X  / reaction
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / complex / reaction
 ENSG00000048649 RSF1 / Q96T23 / remodeling and spacing factor 1  / complex
 ENSG00000009954 BAZ1B / Q9UIG0 / bromodomain adjacent to zinc finger domain 1B  / complex
 ENSG00000137812 KNL1 / Q8NG31 / kinetochore scaffold 1  / complex
 ENSG00000076108 BAZ2A / Q9UIF9 / bromodomain adjacent to zinc finger domain 2A  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr