ENSG00000157450


Homo sapiens

Features
Gene ID: ENSG00000157450
  
Biological name :RNF111
  
Synonyms : Q6ZNA4 / ring finger protein 111 / RNF111
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: 1
Band: q22.1
Gene start: 58865175
Gene end: 59097419
  
Corresponding Affymetrix probe sets: 218761_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000453248
Ensembl peptide - ENSP00000453015
Ensembl peptide - ENSP00000453872
Ensembl peptide - ENSP00000288199
Ensembl peptide - ENSP00000452732
Ensembl peptide - ENSP00000452842
Ensembl peptide - ENSP00000452919
NCBI entrez gene - 54778     See in Manteia.
OMIM - 605840
RefSeq - XM_017022343
RefSeq - XM_011521696
RefSeq - XM_011521697
RefSeq - XM_011521699
RefSeq - XM_017022336
RefSeq - XM_017022337
RefSeq - XM_017022338
RefSeq - XM_017022339
RefSeq - XM_017022340
RefSeq - XM_017022341
RefSeq - XM_017022342
RefSeq - NM_001270528
RefSeq - NM_001270529
RefSeq - NM_001270530
RefSeq - NM_017610
RefSeq - XM_005254479
RefSeq - XM_006720575
RefSeq - XM_006720579
RefSeq - XM_011521694
RefSeq Peptide - NP_001317260
RefSeq Peptide - NP_060080
RefSeq Peptide - NP_001257457
RefSeq Peptide - NP_001257458
RefSeq Peptide - NP_001257459
swissprot - Q6ZNA4
swissprot - H0YKS2
swissprot - H0YLK9
swissprot - H0YKK5
swissprot - A0A024R5T5
Ensembl - ENSG00000157450
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rnf111ENSDARG00000078802Danio rerio
 RNF111ENSGALG00000004171Gallus gallus
 Q99ML9ENSMUSG00000032217Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q6ZSG1 / RNF165 / ring finger protein 165ENSG0000014162215


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR029306  E3 ubiquitin-protein ligase Arkadia, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007389 pattern specification process IEA
 biological_processGO:0016567 protein ubiquitination IMP
 biological_processGO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0030579 ubiquitin-dependent SMAD protein catabolic process IEA
 biological_processGO:0031398 positive regulation of protein ubiquitination IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II TAS
 biological_processGO:0070911 global genome nucleotide-excision repair TAS
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016605 PML body IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0032184 SUMO polymer binding IDA
 molecular_functionGO:0046332 SMAD binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IEA


Pathways (from Reactome)
Pathway description
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Formation of Incision Complex in GG-NER
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000101665 SMAD7 / O15105 / SMAD family member 7  / complex / reaction






 

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