ENSG00000162365


Homo sapiens

Features
Gene ID: ENSG00000162365
  
Biological name :CYP4A22
  
Synonyms : CYP4A22 / cytochrome P450 family 4 subfamily A member 22 / Q5TCH4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p33
Gene start: 47137435
Gene end: 47149741
  
Corresponding Affymetrix probe sets: 1554837_a_at (Human Genome U133 Plus 2.0 Array)   1554931_at (Human Genome U133 Plus 2.0 Array)   207407_x_at (Human Genome U133 Plus 2.0 Array)   211231_x_at (Human Genome U133 Plus 2.0 Array)   217319_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000294337
Ensembl peptide - ENSP00000482952
Ensembl peptide - ENSP00000479019
Ensembl peptide - ENSP00000360958
Ensembl peptide - ENSP00000360957
NCBI entrez gene - 284541     See in Manteia.
OMIM - 615341
RefSeq - NM_001308102
RefSeq - XM_005270770
RefSeq - XM_005270767
RefSeq - NM_001010969
RefSeq Peptide - NP_001010969
RefSeq Peptide - NP_001295031
swissprot - A0A087WZX9
swissprot - Q5TCH4
swissprot - Q5TCH5
swissprot - A0A087WUY4
swissprot - A0A0C4DFN9
Ensembl - ENSG00000162365
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyp4t8ENSDARG00000004964Danio rerio
 CYP4A22ENSGALG00000020688Gallus gallus
 CYP4B7ENSGALG00000010469Gallus gallus
 Cyp4a12bENSMUSG00000078597Mus musculus
 Cyp4a29ENSMUSG00000083138Mus musculus
 Cyp4a30bENSMUSG00000084346Mus musculus
 Cyp4a31ENSMUSG00000028712Mus musculus
 Cyp4a32ENSMUSG00000063929Mus musculus
 O35728ENSMUSG00000028715Mus musculus
 O88833ENSMUSG00000066072Mus musculus
 Q91WL5ENSMUSG00000066071Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q02928 / CYP4A11 / cytochrome P450 family 4 subfamily A member 11ENSG0000018704895
CYP4B1 / P13584 / cytochrome P450 family 4 subfamily B member 1ENSG0000014297350
CYP4Z1 / Q86W10 / cytochrome P450 family 4 subfamily Z member 1ENSG0000018616048
CYP4X1 / Q8N118 / cytochrome P450 family 4 subfamily X member 1ENSG0000018637747
CYP4F3 / Q08477 / cytochrome P450 family 4 subfamily F member 3ENSG0000018652944
Q9HBI6 / CYP4F11 / cytochrome P450 family 4 subfamily F member 11ENSG0000017190343
CYP4F2 / P78329 / cytochrome P450 family 4 subfamily F member 2ENSG0000018611543
Q6NT55 / CYP4F22 / cytochrome P450 family 4 subfamily F member 22ENSG0000017195442
Q9HCS2 / CYP4F12 / cytochrome P450 family 4 subfamily F member 12ENSG0000018620442
CYP4F8 / P98187 / cytochrome P450 family 4 subfamily F member 8ENSG0000018652642
CYP4V2 / Q6ZWL3 / cytochrome P450 family 4 subfamily V member 2ENSG0000014547630


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002401  Cytochrome P450, E-class, group I
 IPR002402  Cytochrome P450, E-class, group II
 IPR017972  Cytochrome P450, conserved site
 IPR036396  Cytochrome P450 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002933 lipid hydroxylation IDA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0102116 laurate hydroxylase activity IDA
 molecular_functionGO:0103002 16-hydroxypalmitate dehydrogenase activity IDA


Pathways (from Reactome)
Pathway description
Fatty acids
Miscellaneous substrates
Eicosanoids
Synthesis of Leukotrienes (LT) and Eoxins (EX)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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