ENSG00000164821


Homo sapiens

Features
Gene ID: ENSG00000164821
  
Biological name :DEFA4
  
Synonyms : DEFA4 / defensin alpha 4 / P12838
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: p23.1
Gene start: 6935822
Gene end: 6938338
  
Corresponding Affymetrix probe sets: 207269_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000297435
NCBI entrez gene - 1669     See in Manteia.
OMIM - 601157
RefSeq - NM_001925
RefSeq Peptide - NP_001916
swissprot - P12838
Ensembl - ENSG00000164821
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
No match


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DEFA5 / Q01523 / defensin alpha 5ENSG0000016481648
DEFA6 / Q01524 / defensin alpha 6ENSG0000016482248
DEFA1 / P59665 / defensin alpha 1ENSG0000020604744
DEFA3 / P59666 / defensin alpha 3ENSG0000023983944
DEFA1B / P59665 / defensin alpha 1BENSG0000024024744


Protein motifs (from Interpro)
Interpro ID Name
 IPR002366  Defensin propeptide
 IPR006080  Beta/alpha defensin
 IPR006081  Alpha-defensin
 IPR016327  Alpha-defensin propeptide


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006952 defense response IEA
 biological_processGO:0019730 antimicrobial humoral response IDA
 biological_processGO:0019731 antibacterial humoral response IDA
 biological_processGO:0019732 antifungal humoral response IDA
 biological_processGO:0031640 killing of cells of other organism IEA
 biological_processGO:0042742 defense response to bacterium IEA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0045087 innate immune response IDA
 biological_processGO:0050829 defense response to Gram-negative bacterium IDA
 biological_processGO:0050830 defense response to Gram-positive bacterium IDA
 biological_processGO:0050832 defense response to fungus IEA
 biological_processGO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005796 Golgi lumen TAS
 cellular_componentGO:0035580 specific granule lumen TAS
 cellular_componentGO:0042582 azurophil granule IDA
 molecular_functionGO:0042803 protein homodimerization activity IDA


Pathways (from Reactome)
Pathway description
Defensins
Alpha-defensins
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000164821 DEFA4 / P12838 / defensin alpha 4  / complex






 

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