ENSG00000167842


Homo sapiens
kinetochoreMIS12chromosomeproteinmismitoticcellsistercyclechromatidcohesionmindcomplexsignalcentromeresegregationlocalizationdivisionattachmentspindlemicrotubulesassemblytypecentromericregioncondensednuclearnucleuscytosolbindingamplification

Features
Gene ID: ENSG00000167842
  
Biological name :MIS12
  
Synonyms : MIS12 / MIS12, kinetochore complex component / Q9H081
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: p13.2
Gene start: 5486285
Gene end: 5490814
  
Corresponding Affymetrix probe sets: 221559_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000459366
Ensembl peptide - ENSP00000461333
Ensembl peptide - ENSP00000484532
Ensembl peptide - ENSP00000370557
Ensembl peptide - ENSP00000461252
NCBI entrez gene - 79003     See in Manteia.
OMIM - 609178
RefSeq - XM_017025035
RefSeq - NM_001258217
RefSeq - NM_001258218
RefSeq - NM_001258219
RefSeq - NM_001258220
RefSeq - NM_024039
RefSeq - XM_005256797
RefSeq - XM_017025033
RefSeq - XM_017025034
RefSeq Peptide - NP_001245149
RefSeq Peptide - NP_001245146
RefSeq Peptide - NP_001245147
RefSeq Peptide - NP_076944
RefSeq Peptide - NP_001245148
swissprot - Q9H081
swissprot - I3L4K6
swissprot - I3L244
Ensembl - ENSG00000167842
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mis12ENSDARG00000026454Danio rerio
 MIS12ENSGALG00000001632Gallus gallus
 Mis12ENSMUSG00000040599Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR008685  Centromere protein Mis12


Gene Ontology (GO)
cell cyclechromosome segregationcellular component organizationmacromolecule localizationcellular localizationcell divisionestablishment of localizationcellular component biogenesiscell cyclechromosome segregationcellular component organizationmacromolecule localizationcellular localizationcell divisionestablishment of localizationcellular component biogenesiscell cyclechromosome segregationcellular component organizationmacromolecule localizationcellular localizationcell divisionestablishment of localizationcellular component biogenesiscell cyclechromosome segregationcellular component organizationmacromolecule localizationcellular localizationcell divisionestablishment of localizationcellular component biogenesiscell cyclechromosome segregationcellular component organizationmacromolecule localizationcellular localizationcell divisionestablishment of localizationcellular component biogenesiscell cyclechromosome segregationcellular component organizationmacromolecule localizationcellular localizationcell divisionestablishment of localizationcellular component biogenesiscell cyclechromosome segregationcellular component organizationmacromolecule localizationcellular localizationcell divisionestablishment of localizationcellular component biogenesiscell cyclechromosome segregationcellular component organizationmacromolecule localizationcellular localizationcell divisionestablishment of localizationcellular component biogenesiscell cyclechromosome segregationcellular component organizationmacromolecule localizationcellular localizationcell divisionestablishment of localizationcellular component biogenesiscell cyclechromosome segregationcellular component organizationmacromolecule localizationcellular localizationcell divisionestablishment of localizationcellular component biogenesiscell cyclecell cyclechromosome segregchromosome segregationcellular componencellular component organizationmacromolecule locmacromolecule localizationcellular localizacellular localizationcell divisioncell divisionestablishment of establishment of localizationcellular componencellular component biogenesis
protein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein binding
cellprotein-containing complexorganellemembrane-enclosed lumencellprotein-containing complexorganellemembrane-enclosed lumencellprotein-containing complexorganellemembrane-enclosed lumencellprotein-containing complexorganellemembrane-enclosed lumencellprotein-containing complexorganellemembrane-enclosed lumencellprotein-containing complexorganellemembrane-enclosed lumencellprotein-containing complexorganellemembrane-enclosed lumencellprotein-containing complexorganellemembrane-enclosed lumencellprotein-containing complexorganellemembrane-enclosed lumencellprotein-containing complexorganellemembrane-enclosed lumencellcellprotein-containing complexprotein-containing complexorganelleorganellemembrane-enclosed lumenmembrane-enclosed lumen
TypeGO IDTermEv.Code
 biological_processGO:0000278 mitotic cell cycle IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007059 chromosome segregation IMP
 biological_processGO:0007062 sister chromatid cohesion TAS
 biological_processGO:0034501 protein localization to kinetochore IBA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051315 attachment of mitotic spindle microtubules to kinetochore IMP
 biological_processGO:0051382 kinetochore assembly IDA
 cellular_componentGO:0000444 MIS12/MIND type complex IDA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0000777 condensed chromosome kinetochore IDA
 cellular_componentGO:0000818 nuclear MIS12/MIND complex IBA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000160783 PMF1 / Q6P1K2 / polyamine modulated factor 1  / complex
 ENSG00000149636 DSN1 / Q9H410 / DSN1 homolog, MIS12 kinetochore complex component  / complex
 ENSG00000117697 NSL1 / Q96IY1 / NSL1, MIS12 kinetochore complex component  / complex
 ENSG00000080986 NDC80 / O14777 / NDC80, kinetochore complex component  / complex
 ENSG00000143228 NUF2 / Q9BZD4 / NUF2, NDC80 kinetochore complex component  / complex
 ENSG00000152253 SPC25 / Q9HBM1 / SPC25, NDC80 kinetochore complex component  / complex
 ENSG00000137812 KNL1 / Q8NG31 / kinetochore scaffold 1  / complex
 ENSG00000161888 SPC24 / Q8NBT2 / SPC24, NDC80 kinetochore complex component  / complex






 

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