ENSG00000171885


Homo sapiens

Features
Gene ID: ENSG00000171885
  
Biological name :AQP4
  
Synonyms : AQP4 / aquaporin 4 / P55087
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 18
Strand: -1
Band: q11.2
Gene start: 26852038
Gene end: 26865818
  
Corresponding Affymetrix probe sets: 210066_s_at (Human Genome U133 Plus 2.0 Array)   210067_at (Human Genome U133 Plus 2.0 Array)   210068_s_at (Human Genome U133 Plus 2.0 Array)   210906_x_at (Human Genome U133 Plus 2.0 Array)   226228_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000372656
Ensembl peptide - ENSP00000462075
Ensembl peptide - ENSP00000462597
Ensembl peptide - ENSP00000372654
Ensembl peptide - ENSP00000393121
NCBI entrez gene - 361     See in Manteia.
OMIM - 600308
RefSeq - XM_011525942
RefSeq - NM_001317384
RefSeq - NM_001317387
RefSeq - NM_001650
RefSeq - NM_004028
RefSeq Peptide - NP_001304313
RefSeq Peptide - NP_001304316
RefSeq Peptide - NP_001641
RefSeq Peptide - NP_004019
swissprot - H0Y3H5
swissprot - F1DSG4
swissprot - P55087
swissprot - J3KRM4
Ensembl - ENSG00000171885
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aqp4ENSDARG00000010565Danio rerio
 AQP4ENSGALG00000015128Gallus gallus
 Aqp4ENSMUSG00000024411Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AQP5 / P55064 / aquaporin 5ENSG0000016179839
AQP2 / P41181 / aquaporin 2ENSG0000016758037
AQP1 / P29972 / aquaporin 1 (Colton blood group)ENSG0000024058337
MIP / P30301 / major intrinsic protein of lens fiberENSG0000013551735
AC004691.2ENSG0000025042435
AQP6 / Q13520 / aquaporin 6ENSG0000008615933
AQP8 / O94778 / aquaporin 8ENSG0000010337521


Protein motifs (from Interpro)
Interpro ID Name
 IPR000425  Major intrinsic protein
 IPR022357  Major intrinsic protein, conserved site
 IPR023271  Aquaporin-like
 IPR034294  Aquaporin transporter


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003091 renal water homeostasis TAS
 biological_processGO:0006833 water transport TAS
 biological_processGO:0034220 ion transmembrane transport IBA
 biological_processGO:0050891 multicellular organismal water homeostasis IEP
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0071346 cellular response to interferon-gamma IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IBA
 molecular_functionGO:0005372 water transmembrane transporter activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015250 water channel activity EXP
 molecular_functionGO:0015267 channel activity IEA


Pathways (from Reactome)
Pathway description
Vasopressin regulates renal water homeostasis via Aquaporins
Passive transport by Aquaporins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000171885 AQP4 / P55087 / aquaporin 4  / complex






 

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