ENSG00000173366


Homo sapiens
receptordomaintoll-likesignalinginterleukin-homologyleucine-richrepeatsuperfamilypathwayresponseregulationbindingtolltiractinmembraneactin-depolymerisingfactortypicalsubtypeadf-hgelsolin-likemoleculebacterialoriginmyd-dependentsignaltransduction

Features
Gene ID: ENSG00000173366
  
Biological name :AC097637.1
  
Synonyms : AC097637.1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: p21.2
Gene start: 52221081
Gene end: 52231190
  
Corresponding Affymetrix probe sets: 223903_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000417517
Ensembl peptide - ENSP00000419980
swissprot - H0Y858
swissprot - H7C5I2
Ensembl - ENSG00000173366
  
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tlr9ENSDARG00000044490Danio rerio
 Tlr9ENSMUSG00000045322Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TLR9 / Q9NR96 / toll like receptor 9ENSG0000023973287
TLR7 / Q9NYK1 / toll like receptor 7ENSG0000019666431
TLR8 / Q9NR97 / toll like receptor 8ENSG0000010191630
TLR3 / O15455 / toll like receptor 3ENSG0000016434218
TLR4 / O00206 / toll like receptor 4ENSG0000013686916
TLR2 / O60603 / toll like receptor 2ENSG0000013746215
TLR5 / O60602 / toll like receptor 5ENSG0000018755415
CD180 / Q99467 / CD180 moleculeENSG0000013406114
TLR10 / Q9BXR5 / toll like receptor 10ENSG0000017412313
TLR1 / Q15399 / toll like receptor 1ENSG0000017412513
TLR6 / Q9Y2C9 / toll like receptor 6ENSG0000017413013


Protein motifs (from Interpro)
Interpro ID Name
 IPR000157  Toll/interleukin-1 receptor homology (TIR) domain
 IPR001611  Leucine-rich repeat
 IPR002108  Actin-depolymerising factor homology domain
 IPR003591  Leucine-rich repeat, typical subtype
 IPR027181  Toll-like receptor 9
 IPR029006  ADF-H/Gelsolin-like domain superfamily
 IPR032675  Leucine-rich repeat domain superfamily
 IPR035897  Toll/interleukin-1 receptor homology (TIR) domain superfamily


Gene Ontology (GO)
response to stressimmune responsecell communicationcellular response to stimulusresponse to external stimulusresponse to chemicalresponse to biotic stimuluscellular component organizationanatomical structure developmentcellular developmental processcellular component biogenesisregulation of biological qualityactin filament-based processmacromolecule localizationestablishment of localizationcytokine productionresponse to stressimmune responsecell communicationcellular response to stimulusresponse to external stimulusresponse to chemicalresponse to biotic stimuluscellular component organizationanatomical structure developmentcellular developmental processcellular component biogenesisregulation of biological qualityactin filament-based processmacromolecule localizationestablishment of localizationcytokine productionresponse to stressimmune responsecell communicationcellular response to stimulusresponse to external stimulusresponse to chemicalresponse to biotic stimuluscellular component organizationanatomical structure developmentcellular developmental processcellular component biogenesisregulation of biological qualityactin filament-based processmacromolecule localizationestablishment of localizationcytokine productionresponse to stressimmune responsecell communicationcellular response to stimulusresponse to external stimulusresponse to chemicalresponse to biotic stimuluscellular component organizationanatomical structure developmentcellular developmental processcellular component biogenesisregulation of biological qualityactin filament-based processmacromolecule localizationestablishment of localizationcytokine productionresponse to stressimmune responsecell communicationcellular response to stimulusresponse to external stimulusresponse to chemicalresponse to biotic stimuluscellular component organizationanatomical structure developmentcellular developmental processcellular component biogenesisregulation of biological qualityactin filament-based processmacromolecule localizationestablishment of localizationcytokine productionresponse to stressimmune responsecell communicationcellular response to stimulusresponse to external stimulusresponse to chemicalresponse to biotic stimuluscellular component organizationanatomical structure developmentcellular developmental processcellular component biogenesisregulation of biological qualityactin filament-based processmacromolecule localizationestablishment of localizationcytokine productionresponse to stressimmune responsecell communicationcellular response to stimulusresponse to external stimulusresponse to chemicalresponse to biotic stimuluscellular component organizationanatomical structure developmentcellular developmental processcellular component biogenesisregulation of biological qualityactin filament-based processmacromolecule localizationestablishment of localizationcytokine productionresponse to stressimmune responsecell communicationcellular response to stimulusresponse to external stimulusresponse to chemicalresponse to biotic stimuluscellular component organizationanatomical structure developmentcellular developmental processcellular component biogenesisregulation of biological qualityactin filament-based processmacromolecule localizationestablishment of localizationcytokine productionresponse to stressimmune responsecell communicationcellular response to stimulusresponse to external stimulusresponse to chemicalresponse to biotic stimuluscellular component organizationanatomical structure developmentcellular developmental processcellular component biogenesisregulation of biological qualityactin filament-based processmacromolecule localizationestablishment of localizationcytokine productionresponse to stressimmune responsecell communicationcellular response to stimulusresponse to external stimulusresponse to chemicalresponse to biotic stimuluscellular component organizationanatomical structure developmentcellular developmental processcellular component biogenesisregulation of biological qualityactin filament-based processmacromolecule localizationestablishment of localizationcytokine productionresponseresponse to stressimmune rimmune responsecell comcell communicationcellularcellular response to stimulusresponseresponse to external stimulusresponseresponse to chemicalresponseresponse to biotic stimuluscellularcellular component organizationanatomicanatomical structure developmentcellularcellular developmental processcellularcellular component biogenesisregulatiregulation of biological qualityactin fiactin filament-based processmacromolmacromolecule localizationestablisestablishment of localizationcytokinecytokine production
protein bindingsignaling receptor activityprotein bindingsignaling receptor activityprotein bindingsignaling receptor activityprotein bindingsignaling receptor activityprotein bindingsignaling receptor activityprotein bindingsignaling receptor activityprotein bindingsignaling receptor activityprotein bindingsignaling receptor activityprotein bindingsignaling receptor activityprotein bindingsignaling receptor activityprotein bindingprotein bindingsignaling receptor activitysignaling receptor activity
extracellular regioncellmembraneextracellular regioncellmembraneextracellular regioncellmembraneextracellular regioncellmembraneextracellular regioncellmembraneextracellular regioncellmembraneextracellular regioncellmembraneextracellular regioncellmembraneextracellular regioncellmembraneextracellular regioncellmembraneextracellular regionextracellular regioncellcellmembranemembrane
TypeGO IDTermEv.Code
 biological_processGO:0002224 toll-like receptor signaling pathway IBA
 biological_processGO:0002237 response to molecule of bacterial origin IBA
 biological_processGO:0002755 MyD88-dependent toll-like receptor signaling pathway IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007409 axonogenesis IBA
 biological_processGO:0030837 negative regulation of actin filament polymerization IEA
 biological_processGO:0034162 toll-like receptor 9 signaling pathway IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0050707 regulation of cytokine secretion IEA
 biological_processGO:0050729 positive regulation of inflammatory response IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005149 interleukin-1 receptor binding IBA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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