ENSG00000177380


Homo sapiens
PPFIA3releasecyclesterilealphamotifdomainproteinsecretionglutamatevesiclepointedsuperfamilylar-interactingliprinliprin-alpha-regulationshort-termneuronalsynapticplasticityacrosomalcytoplasmcytosolcytoplasmicpresynapticactivezoneepididymosomebinding

Features
Gene ID: ENSG00000177380
  
Biological name :PPFIA3
  
Synonyms : O75145 / PPFIA3 / PTPRF interacting protein alpha 3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.33
Gene start: 49119389
Gene end: 49151026
  
Corresponding Affymetrix probe sets: 213368_x_at (Human Genome U133 Plus 2.0 Array)   215280_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000473621
Ensembl peptide - ENSP00000473423
Ensembl peptide - ENSP00000473622
Ensembl peptide - ENSP00000473470
Ensembl peptide - ENSP00000335614
Ensembl peptide - ENSP00000473418
NCBI entrez gene - 8541     See in Manteia.
OMIM - 603144
RefSeq - NM_003660
RefSeq - XM_017027407
RefSeq Peptide - NP_003651
swissprot - R4GN36
swissprot - R4GNF1
swissprot - O75145
swissprot - A0A0C4DGR7
swissprot - A0A0C4DGR8
Ensembl - ENSG00000177380
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppfia3ENSDARG00000077053Danio rerio
 P60469ENSMUSG00000003863Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PPFIA1 / Q13136 / PTPRF interacting protein alpha 1ENSG0000013162663
O75334 / PPFIA2 / PTPRF interacting protein alpha 2ENSG0000013922062
O75335 / PPFIA4 / PTPRF interacting protein alpha 4ENSG0000014384758
Q86W92 / PPFIBP1 / PPFIA binding protein 1ENSG0000011084118
Q8ND30 / PPFIBP2 / PPFIA binding protein 2ENSG0000016638718
KAZN / Q674X7 / kazrin, periplakin interacting proteinENSG0000018933718


Protein motifs (from Interpro)
Interpro ID Name
 IPR001660  Sterile alpha motif domain
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR029515  LAR-interacting protein, Liprin
 IPR030440  Liprin-alpha-3


Gene Ontology (GO)
cell communicationestablishment of localizationregulation of biological qualitycellular localizationcell communicationestablishment of localizationregulation of biological qualitycellular localizationcell communicationestablishment of localizationregulation of biological qualitycellular localizationcell communicationestablishment of localizationregulation of biological qualitycellular localizationcell communicationestablishment of localizationregulation of biological qualitycellular localizationcell communicationestablishment of localizationregulation of biological qualitycellular localizationcell communicationestablishment of localizationregulation of biological qualitycellular localizationcell communicationestablishment of localizationregulation of biological qualitycellular localizationcell communicationestablishment of localizationregulation of biological qualitycellular localizationcell communicationestablishment of localizationregulation of biological qualitycellular localizationcell communicationcell communicationestablishment of localizationestablishment of localizationregulation of biological qualityregulation of biological qualitycellular localizationcellular localization
protein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein binding
cellorganellesynapseextracellular regioncellorganellesynapseextracellular regioncellorganellesynapseextracellular regioncellorganellesynapseextracellular regioncellorganellesynapseextracellular regioncellorganellesynapseextracellular regioncellorganellesynapseextracellular regioncellorganellesynapseextracellular regioncellorganellesynapseextracellular regioncellorganellesynapseextracellular regioncellcellorganelleorganellesynapsesynapseextracellular regionextracellular region
TypeGO IDTermEv.Code
 biological_processGO:0007269 neurotransmitter secretion IEA
 biological_processGO:0014047 glutamate secretion TAS
 biological_processGO:0048172 regulation of short-term neuronal synaptic plasticity ISS
 cellular_componentGO:0001669 acrosomal vesicle IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0048786 presynaptic active zone IEA
 cellular_componentGO:0098875 epididymosome ISS
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Serotonin Neurotransmitter Release Cycle
Norepinephrine Neurotransmitter Release Cycle
Glutamate Neurotransmitter Release Cycle
Dopamine Neurotransmitter Release Cycle
Acetylcholine Neurotransmitter Release Cycle
Receptor-type tyrosine-protein phosphatases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000079841 RIMS1 / Q86UR5 / regulating synaptic membrane exocytosis 1  / complex
 ENSG00000105426 PTPRS / Q13332 / protein tyrosine phosphatase, receptor type S  / complex / reaction
 ENSG00000005379 O95153 / TSPOAP1 / TSPO associated protein 1  / complex
 ENSG00000153707 PTPRD / P23468 / protein tyrosine phosphatase, receptor type D  / complex / reaction
 ENSG00000142949 PTPRF / P10586 / protein tyrosine phosphatase, receptor type F  / complex / reaction
 ENSG00000198722 O14795 / UNC13B / unc-13 homolog B  / complex






 

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