ENSG00000178035


Homo sapiens

Features
Gene ID: ENSG00000178035
  
Biological name :IMPDH2
  
Synonyms : IMPDH2 / inosine monophosphate dehydrogenase 2 / P12268
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: p21.31
Gene start: 49024325
Gene end: 49029408
  
Corresponding Affymetrix probe sets: 201892_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000403502
Ensembl peptide - ENSP00000321584
Ensembl peptide - ENSP00000393525
NCBI entrez gene - 3615     See in Manteia.
OMIM - 146691
RefSeq - XM_017006350
RefSeq - NM_000884
RefSeq - XM_006713128
RefSeq - XM_017006349
RefSeq Peptide - NP_000875
swissprot - P12268
swissprot - H0Y4R1
swissprot - E7ETK5
Ensembl - ENSG00000178035
  
Related genetic diseases (OMIM): 617995 - [IMPDH2 enzyme activity, variation in], 617995
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 B0UXP9ENSDARG00000006900Danio rerio
 IMPDH2ENSGALG00000006910Gallus gallus
 Impdh2ENSMUSG00000062867Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IMPDH1 / P20839 / inosine monophosphate dehydrogenase 1ENSG0000010634884
GMPR2 / Q9P2T1 / guanosine monophosphate reductase 2ENSG0000010093820
GMPR / P36959 / guanosine monophosphate reductaseENSG0000013719819


Protein motifs (from Interpro)
Interpro ID Name
 IPR000644  CBS domain
 IPR001093  IMP dehydrogenase/GMP reductase
 IPR005990  Inosine-5"-monophosphate dehydrogenase
 IPR013785  Aldolase-type TIM barrel
 IPR015875  IMP dehydrogenase / GMP reductase, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006164 purine nucleotide biosynthetic process IEA
 biological_processGO:0006177 GMP biosynthetic process IEA
 biological_processGO:0006183 GTP biosynthetic process IBA
 biological_processGO:0007623 circadian rhythm IDA
 biological_processGO:0009168 purine ribonucleoside monophosphate biosynthetic process TAS
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0046651 lymphocyte proliferation IEA
 biological_processGO:0051289 protein homotetramerization IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060041 retina development in camera-type eye IEA
 biological_processGO:0071353 cellular response to interleukin-4 IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005778 peroxisomal membrane HDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0034774 secretory granule lumen TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:1904813 ficolin-1-rich granule lumen TAS
 molecular_functionGO:0000166 nucleotide binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003938 IMP dehydrogenase activity EXP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation
Purine ribonucleoside monophosphate biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000178035 IMPDH2 / P12268 / inosine monophosphate dehydrogenase 2  / complex






 

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