ENSG00000179934


Homo sapiens

Features
Gene ID: ENSG00000179934
  
Biological name :CCR8
  
Synonyms : C-C motif chemokine receptor 8 / CCR8 / P51685
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: p22.1
Gene start: 39329706
Gene end: 39333511
  
Corresponding Affymetrix probe sets: 208059_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000326432
Ensembl peptide - ENSP00000390104
NCBI entrez gene - 1237     See in Manteia.
OMIM - 601834
RefSeq - NM_005201
RefSeq Peptide - NP_005192
swissprot - C9JIP9
swissprot - P51685
Ensembl - ENSG00000179934
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cabz01093075.1ENSDARG00000086616Danio rerio
 ccr8.1ENSDARG00000095789Danio rerio
 si:cabz01093077.1ENSDARG00000105467Danio rerio
 CCR8ENSGALG00000038069Gallus gallus
 CCR8LENSGALG00000011734Gallus gallus
 Ccr8ENSMUSG00000042262Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CCR4 / P51679 / C-C motif chemokine receptor 4ENSG0000018381343
CCR5 / P51681 / C-C motif chemokine receptor 5 (gene/pseudogene)ENSG0000016079140
CCR1 / P32246 / C-C motif chemokine receptor 1ENSG0000016382339
CX3CR1 / P49238 / C-X3-C motif chemokine receptor 1ENSG0000016832938
CCR2 / P41597 / C-C motif chemokine receptor 2ENSG0000012180737
CCR3 / P51677 / C-C motif chemokine receptor 3ENSG0000018362536
ACKR2 / O00590 / atypical chemokine receptor 2ENSG0000014464833
CXCR1 / P25024 / C-X-C motif chemokine receptor 1ENSG0000016346432
XCR1 / P46094 / X-C motif chemokine receptor 1ENSG0000017357832
CXCR2 / P25025 / C-X-C motif chemokine receptor 2ENSG0000018087132
CCR6 / P51684 / C-C motif chemokine receptor 6ENSG0000011248631
CXCR4 / P61073 / C-X-C motif chemokine receptor 4ENSG0000012196630
CCR7 / P32248 / C-C motif chemokine receptor 7ENSG0000012635329
CCR9 / P51686 / C-C motif chemokine receptor 9ENSG0000017358529
ACKR4 / Q9NPB9 / atypical chemokine receptor 4ENSG0000012904828
CXCR6 / O00574 / C-X-C motif chemokine receptor 6ENSG0000017221527
CXCR3 / P49682 / C-X-C motif chemokine receptor 3ENSG0000018681027
CXCR5 / P32302 / C-X-C motif chemokine receptor 5ENSG0000016068326
CCR10 / P46092 / C-C motif chemokine receptor 10ENSG0000018445123


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000355  Chemokine receptor family
 IPR004068  CC chemokine receptor 8
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006935 chemotaxis TAS
 biological_processGO:0006955 immune response TAS
 biological_processGO:0007155 cell adhesion TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration TAS
 biological_processGO:0070098 chemokine-mediated signaling pathway IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004950 chemokine receptor activity TAS
 molecular_functionGO:0015026 coreceptor activity TAS
 molecular_functionGO:0016493 C-C chemokine receptor activity IEA


Pathways (from Reactome)
Pathway description
Chemokine receptors bind chemokines
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000108702 CCL1 / P22362 / C-C motif chemokine ligand 1  / complex / reaction
 ENSG00000275152 CCL16 / O15467 / C-C motif chemokine ligand 16  / complex / reaction






 

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