ENSG00000144648


Homo sapiens

Features
Gene ID: ENSG00000144648
  
Biological name :ACKR2
  
Synonyms : ACKR2 / atypical chemokine receptor 2 / O00590
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: p22.1
Gene start: 42804752
Gene end: 42887974
  
Corresponding Affymetrix probe sets: 1568850_at (Human Genome U133 Plus 2.0 Array)   206887_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000476901
Ensembl peptide - ENSP00000477475
Ensembl peptide - ENSP00000477157
Ensembl peptide - ENSP00000396150
Ensembl peptide - ENSP00000416996
Ensembl peptide - ENSP00000476581
NCBI entrez gene - 1238     See in Manteia.
OMIM - 602648
RefSeq - NM_001296
RefSeq Peptide - NP_001287
swissprot - V9GYM0
swissprot - V9GYX0
swissprot - A0A024R2X7
swissprot - V9GZ70
swissprot - O00590
swissprot - V9GYB7
Ensembl - ENSG00000144648
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ACKR2ENSGALG00000005305Gallus gallus
 Ackr2ENSMUSG00000044534Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CCR1 / P32246 / C-C motif chemokine receptor 1ENSG0000016382335
CCR4 / P51679 / C-C motif chemokine receptor 4ENSG0000018381335
CCR3 / P51677 / C-C motif chemokine receptor 3ENSG0000018362532
CCR2 / P41597 / C-C motif chemokine receptor 2ENSG0000012180731
CCR5 / P51681 / C-C motif chemokine receptor 5 (gene/pseudogene)ENSG0000016079131
CX3CR1 / P49238 / C-X3-C motif chemokine receptor 1ENSG0000016832931
XCR1 / P46094 / X-C motif chemokine receptor 1ENSG0000017357830
CCR8 / P51685 / C-C motif chemokine receptor 8ENSG0000017993430
CXCR2 / P25025 / C-X-C motif chemokine receptor 2ENSG0000018087130
CXCR3 / P49682 / C-X-C motif chemokine receptor 3ENSG0000018681030
CXCR1 / P25024 / C-X-C motif chemokine receptor 1ENSG0000016346429
CCR9 / P51686 / C-C motif chemokine receptor 9ENSG0000017358529
CCR10 / P46092 / C-C motif chemokine receptor 10ENSG0000018445129
CCR6 / P51684 / C-C motif chemokine receptor 6ENSG0000011248628
CXCR4 / P61073 / C-X-C motif chemokine receptor 4ENSG0000012196628
CCR7 / P32248 / C-C motif chemokine receptor 7ENSG0000012635328
ACKR4 / Q9NPB9 / atypical chemokine receptor 4ENSG0000012904827
CXCR5 / P32302 / C-X-C motif chemokine receptor 5ENSG0000016068327
CXCR6 / O00574 / C-X-C motif chemokine receptor 6ENSG0000017221524


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000355  Chemokine receptor family
 IPR001277  CXC chemokine receptor 4/atypical chemokine receptor 2
 IPR017452  GPCR, rhodopsin-like, 7TM
 IPR033037  Atypical chemokine receptor 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006955 immune response TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007275 multicellular organism development TAS
 biological_processGO:0070098 chemokine-mediated signaling pathway IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005884 actin filament IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031965 nuclear membrane IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0055037 recycling endosome IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004950 chemokine receptor activity IEA
 molecular_functionGO:0005044 scavenger receptor activity IEA
 molecular_functionGO:0016493 C-C chemokine receptor activity IEA
 molecular_functionGO:0019957 C-C chemokine binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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