ENSG00000180263


Homo sapiens

Features
Gene ID: ENSG00000180263
  
Biological name :FGD6
  
Synonyms : FGD6 / FYVE, RhoGEF and PH domain containing 6 / Q6ZV73
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q22
Gene start: 95076749
Gene end: 95217482
  
Corresponding Affymetrix probe sets: 1555136_at (Human Genome U133 Plus 2.0 Array)   1555137_a_at (Human Genome U133 Plus 2.0 Array)   219901_at (Human Genome U133 Plus 2.0 Array)   226799_at (Human Genome U133 Plus 2.0 Array)   243142_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000450240
Ensembl peptide - ENSP00000450342
Ensembl peptide - ENSP00000344446
Ensembl peptide - ENSP00000408291
Ensembl peptide - ENSP00000448350
Ensembl peptide - ENSP00000449005
NCBI entrez gene - 55785     See in Manteia.
OMIM - 613520
RefSeq - NM_018351
RefSeq Peptide - NP_060821
swissprot - F8VY01
swissprot - H0YI21
swissprot - Q6ZV73
swissprot - F8VQX5
swissprot - F8VWT6
Ensembl - ENSG00000180263
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fgd6ENSDARG00000045528Danio rerio
 FGD6ENSGALG00000011342Gallus gallus
 Fgd6ENSMUSG00000020021Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FGD5 / Q6ZNL6 / FYVE, RhoGEF and PH domain containing 5ENSG0000015478329
FGD1 / P98174 / FYVE, RhoGEF and PH domain containing 1ENSG0000010230216
FGD4 / Q96M96 / FYVE, RhoGEF and PH domain containing 4ENSG0000013913215
FGD2 / Q7Z6J4 / FYVE, RhoGEF and PH domain containing 2ENSG0000014619213
FGD3 / Q5JSP0 / FYVE, RhoGEF and PH domain containing 3ENSG0000012708412
Q96S99 / PLEKHF1 / pleckstrin homology and FYVE domain containing 1ENSG000001662896
Q9H8W4 / PLEKHF2 / pleckstrin homology and FYVE domain containing 2ENSG000001758956


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR000306  FYVE zinc finger
 IPR001849  Pleckstrin homology domain
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR011993  PH-like domain superfamily
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017455  Zinc finger, FYVE-related
 IPR035899  Dbl homology (DH) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007010 cytoskeleton organization ISS
 biological_processGO:0008360 regulation of cell shape ISS
 biological_processGO:0030036 actin cytoskeleton organization ISS
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0046847 filopodium assembly ISS
 cellular_componentGO:0001726 ruffle ISS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005794 Golgi apparatus ISS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0030027 lamellipodium ISS
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0031267 small GTPase binding ISS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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