ENSG00000181467


Homo sapiens

Features
Gene ID: ENSG00000181467
  
Biological name :RAP2B
  
Synonyms : P61225 / RAP2B / RAP2B, member of RAS oncogene family
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: q25.2
Gene start: 153162270
Gene end: 153170620
  
Corresponding Affymetrix probe sets: 213923_at (Human Genome U133 Plus 2.0 Array)   214487_s_at (Human Genome U133 Plus 2.0 Array)   214488_at (Human Genome U133 Plus 2.0 Array)   238622_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000319096
NCBI entrez gene - 5912     See in Manteia.
OMIM - 179541
RefSeq - NM_002886
RefSeq Peptide - NP_002877
swissprot - P61225
Ensembl - ENSG00000181467
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rap2bENSDARG00000103032Danio rerio
 RAP2BENSGALG00000042553Gallus gallus
 Rap2bENSMUSG00000036894Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RAP2A / P10114 / RAP2A, member of RAS oncogene familyENSG0000012524991
RAP2C / Q9Y3L5 / RAP2C, member of RAS oncogene familyENSG0000012372886
RAP1A / P62834 / RAP1A, member of RAS oncogene familyENSG0000011647362
RAP1B / P61224 / RAP1B, member of RAS oncogene familyENSG0000012731461
DIRAS2 / Q96HU8 / DIRAS family GTPase 2ENSG0000016502346
RIT1 / Q92963 / Ras like without CAAX 1ENSG0000014362245
DIRAS1 / O95057 / DIRAS family GTPase 1ENSG0000017649045
RIT2 / Q99578 / Ras like without CAAX 2ENSG0000015221443
RASD1 / Q9Y272 / ras related dexamethasone induced 1ENSG0000010855139
RASD2 / Q96D21 / RASD family member 2ENSG0000010030238
DIRAS3 / O95661 / DIRAS family GTPase 3ENSG0000016259533
Q92737 / RASL10A / RAS like family 10 member AENSG0000010027631
Q96S79 / RASL10B / RAS like family 10 member BENSG0000027088531


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR020849  Small GTPase superfamily, Ras-type
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0030168 platelet activation IDA
 biological_processGO:0030336 negative regulation of cell migration IEA
 biological_processGO:0031954 positive regulation of protein autophosphorylation IEA
 biological_processGO:0032486 Rap protein signal transduction IEA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0061097 regulation of protein tyrosine kinase activity IEA
 biological_processGO:0070527 platelet aggregation IDA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005923 bicellular tight junction IDA
 cellular_componentGO:0016020 membrane IMP
 cellular_componentGO:0035579 specific granule membrane TAS
 cellular_componentGO:0044291 cell-cell contact zone IDA
 cellular_componentGO:0045121 membrane raft IMP
 cellular_componentGO:0055037 recycling endosome IEA
 cellular_componentGO:0055038 recycling endosome membrane ISS
 cellular_componentGO:0070062 extracellular exosome IDA
 cellular_componentGO:0070821 tertiary granule membrane TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding TAS
 molecular_functionGO:0019003 GDP binding IDA
 molecular_functionGO:0019904 protein domain specific binding IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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