ENSG00000185294


Homo sapiens

Features
Gene ID: ENSG00000185294
  
Biological name :SPPL2C
  
Synonyms : Q8IUH8 / signal peptide peptidase like 2C / SPPL2C
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q21.31
Gene start: 45844835
Gene end: 45847072
  
Corresponding Affymetrix probe sets: 231253_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000332488
NCBI entrez gene - 162540     See in Manteia.
OMIM - 608284
RefSeq - NM_175882
RefSeq Peptide - NP_787078
swissprot - Q8IUH8
Ensembl - ENSG00000185294
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A2A6C4ENSMUSG00000049506Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8TCT7 / SPPL2B / signal peptide peptidase like 2BENSG0000000520640
Q8TCT8 / SPPL2A / signal peptide peptidase like 2AENSG0000013860030
SPPL3 / Q8TCT6 / signal peptide peptidase like 3ENSG0000015783713
HM13 / Q8TCT9 / histocompatibility minor 13ENSG0000010129412


Protein motifs (from Interpro)
Interpro ID Name
 IPR006639  Presenilin/signal peptide peptidase
 IPR007369  Peptidase A22B, signal peptide peptidase
 IPR033150  Signal peptide peptidase-like 2C


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 cellular_componentGO:0005765 lysosomal membrane IBA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030660 Golgi-associated vesicle membrane IBA
 cellular_componentGO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane IDA
 cellular_componentGO:0071556 integral component of lumenal side of endoplasmic reticulum membrane IDA
 molecular_functionGO:0004190 aspartic-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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