ENSG00000185813


Homo sapiens
processactivityPCYT2biosyntheticalphacytidyltransferase-likedomainrossmann-likebetasandwichfoldlipidmetabolicphosphatidylethanolaminephospholipidcellularcomponentendoplasmicreticulummembranecatalyticethanolamine-phosphatecytidylyltransferasetransferasenucleotidyltransferasesynthesispe

Features
Gene ID: ENSG00000185813
  
Biological name :PCYT2
  
Synonyms : PCYT2 / phosphate cytidylyltransferase 2, ethanolamine / Q99447
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q25.3
Gene start: 81900965
Gene end: 81911464
  
Corresponding Affymetrix probe sets: 209577_at (Human Genome U133 Plus 2.0 Array)   230044_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000461814
Ensembl peptide - ENSP00000460767
Ensembl peptide - ENSP00000461190
Ensembl peptide - ENSP00000331719
Ensembl peptide - ENSP00000439245
Ensembl peptide - ENSP00000442050
Ensembl peptide - ENSP00000458330
Ensembl peptide - ENSP00000458472
Ensembl peptide - ENSP00000458727
Ensembl peptide - ENSP00000458805
Ensembl peptide - ENSP00000458931
Ensembl peptide - ENSP00000459044
Ensembl peptide - ENSP00000459836
NCBI entrez gene - 5833     See in Manteia.
OMIM - 602679
RefSeq - XM_017024912
RefSeq - NM_001184917
RefSeq - NM_001256433
RefSeq - NM_001256434
RefSeq - NM_001256435
RefSeq - NM_001282203
RefSeq - NM_001282204
RefSeq - NM_002861
RefSeq - XM_005256386
RefSeq - XM_005256387
RefSeq - XM_006722287
RefSeq - XM_017024910
RefSeq - XM_017024911
RefSeq Peptide - NP_001243362
RefSeq Peptide - NP_001243363
RefSeq Peptide - NP_001171846
RefSeq Peptide - NP_001243364
RefSeq Peptide - NP_001269132
RefSeq Peptide - NP_001269133
RefSeq Peptide - NP_001317447
RefSeq Peptide - NP_002852
swissprot - I3NI16
swissprot - I3L1R7
swissprot - I3L102
swissprot - I3L1C4
swissprot - I3L1F9
swissprot - I3L1L9
swissprot - Q99447
swissprot - I3L2Q1
swissprot - I3L3V9
Ensembl - ENSG00000185813
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pcyt2ENSDARG00000043003Danio rerio
 PCYT2ENSGALG00000007251Gallus gallus
 Pcyt2ENSMUSG00000025137Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004821  Cytidyltransferase-like domain
 IPR014729  Rossmann-like alpha/beta/alpha sandwich fold


Gene Ontology (GO)
primary metabolic processorganic substance metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processbiosynthetic processcellular metabolic processprimary metabolic processprimary metabolic processorganic substance metabolic processorganic substance metabolic processbiosynthetic processbiosynthetic processcellular metabolic processcellular metabolic process
transferase activitytransferase activitytransferase activitytransferase activitytransferase activitytransferase activitytransferase activitytransferase activitytransferase activitytransferase activitytransferase activitytransferase activity
cellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellcellmembranemembraneorganelleorganelle
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006646 phosphatidylethanolamine biosynthetic process TAS
 biological_processGO:0008654 phospholipid biosynthetic process TAS
 biological_processGO:0009058 biosynthetic process IEA
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004306 ethanolamine-phosphate cytidylyltransferase activity TAS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016779 nucleotidyltransferase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of PE


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000185813 PCYT2 / Q99447 / phosphate cytidylyltransferase 2, ethanolamine  / complex






 

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