ENSG00000186038


Homo sapiens
ion-channelHTR3Etransmembranedomainionactivitytransportmembranechannelligand-bindingsuperfamilysignaltransmissionconservedsitetransductionchemicalsynapticcationplasmaintegralcomponentsignalingreceptorextracellularligand-gatedserotonin-gatedcation-selectiveneurotransmitterreceptors

Features
Gene ID: ENSG00000186038
  
Biological name :HTR3E
  
Synonyms : 5-hydroxytryptamine receptor 3E / A5X5Y0 / HTR3E
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: q27.1
Gene start: 184097064
Gene end: 184106995
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSP00000401444
Ensembl peptide - ENSP00000395833
Ensembl peptide - ENSP00000401900
Ensembl peptide - ENSP00000406050
Ensembl peptide - ENSP00000335511
Ensembl peptide - ENSP00000391254
NCBI entrez gene - 285242     See in Manteia.
OMIM - 610123
RefSeq - NM_001256613
RefSeq - NM_001256614
RefSeq - NM_182589
RefSeq - NM_198313
RefSeq - NM_198314
RefSeq Peptide - NP_001243543
RefSeq Peptide - NP_872395
RefSeq Peptide - NP_001243542
RefSeq Peptide - NP_938055
RefSeq Peptide - NP_938056
swissprot - C9J420
swissprot - A5X5Y0
Ensembl - ENSG00000186038
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HTR3CENSDARG00000077959Danio rerio
 ENSGALG00000026015Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HTR3C / Q8WXA8 / 5-hydroxytryptamine receptor 3CENSG0000017808468
HTR3D / Q70Z44 / 5-hydroxytryptamine receptor 3DENSG0000018609057
HTR3A / P46098 / 5-hydroxytryptamine receptor 3AENSG0000016673633
HTR3B / O95264 / 5-hydroxytryptamine receptor 3BENSG0000014930527
CHRNA7 / P36544 / cholinergic receptor nicotinic alpha 7 subunitENSG0000017534422
Q9GZZ6 / CHRNA10 / cholinergic receptor nicotinic alpha 10 subunitENSG0000012974920
CHRND / Q07001 / cholinergic receptor nicotinic delta subunitENSG0000013590220
CHRNB1 / P11230 / cholinergic receptor nicotinic beta 1 subunitENSG0000017017519
CHRNA9 / Q9UGM1 / cholinergic receptor nicotinic alpha 9 subunitENSG0000017434319
CHRNG / P07510 / cholinergic receptor nicotinic gamma subunitENSG0000019681119
CHRNE / Q04844 / cholinergic receptor nicotinic epsilon subunitENSG0000010855617
Q494W8 / CHRFAM7A / CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusionENSG0000016666417


Protein motifs (from Interpro)
Interpro ID Name
 IPR006029  Neurotransmitter-gated ion-channel transmembrane domain
 IPR006201  Neurotransmitter-gated ion-channel
 IPR006202  Neurotransmitter-gated ion-channel ligand-binding domain
 IPR018000  Neurotransmitter-gated ion-channel, conserved site
 IPR036719  Neurotransmitter-gated ion-channel transmembrane domain superfamily
 IPR036734  Neurotransmitter-gated ion-channel ligand-binding domain superfamily


Gene Ontology (GO)
establishment of localizationcell communicationcellular response to stimulusestablishment of localizationcell communicationcellular response to stimulusestablishment of localizationcell communicationcellular response to stimulusestablishment of localizationcell communicationcellular response to stimulusestablishment of localizationcell communicationcellular response to stimulusestablishment of localizationcell communicationcellular response to stimulusestablishment of localizationcell communicationcellular response to stimulusestablishment of localizationcell communicationcellular response to stimulusestablishment of localizationcell communicationcellular response to stimulusestablishment of localizationcell communicationcellular response to stimulusestablishment of localizationestablishment of localizationcell communicationcell communicationcellular response to stimuluscellular response to stimulus
signaling receptor activitytransmembrane transporter activitysignaling receptor activitytransmembrane transporter activitysignaling receptor activitytransmembrane transporter activitysignaling receptor activitytransmembrane transporter activitysignaling receptor activitytransmembrane transporter activitysignaling receptor activitytransmembrane transporter activitysignaling receptor activitytransmembrane transporter activitysignaling receptor activitytransmembrane transporter activitysignaling receptor activitytransmembrane transporter activitysignaling receptor activitytransmembrane transporter activitysignaling receptor activitysignaling receptor activitytransmembrane transporter activitytransmembrane transporter activity
cellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellcellmembranemembrane
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007268 chemical synaptic transmission TAS
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0098655 cation transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005230 extracellular ligand-gated ion channel activity IEA
 molecular_functionGO:0022850 serotonin-gated cation-selective channel activity IDA


Pathways (from Reactome)
Pathway description
Neurotransmitter receptors and postsynaptic signal transmission


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000166736 HTR3A / P46098 / 5-hydroxytryptamine receptor 3A  / complex
 ENSG00000186038 HTR3E / A5X5Y0 / 5-hydroxytryptamine receptor 3E  / complex






 

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