ENSG00000188342


Homo sapiens

Features
Gene ID: ENSG00000188342
  
Biological name :GTF2F2
  
Synonyms : general transcription factor IIF subunit 2 / GTF2F2 / P13984
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 13
Strand: 1
Band: q14.12
Gene start: 45120515
Gene end: 45284909
  
Corresponding Affymetrix probe sets: 209595_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000340823
NCBI entrez gene - 2963     See in Manteia.
OMIM - 189969
RefSeq - XM_017020551
RefSeq - NM_004128
RefSeq - XM_011535052
RefSeq Peptide - NP_004119
swissprot - P13984
swissprot - A0A024RDU9
Ensembl - ENSG00000188342
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gtf2f2aENSDARG00000069910Danio rerio
 gtf2f2bENSDARG00000006816Danio rerio
 GTF2F2ENSGALG00000016974Gallus gallus
 Gtf2f2ENSMUSG00000067995Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003196  Transcription initiation factor IIF, beta subunit
 IPR011039  Transcription Factor IIF, Rap30/Rap74, interaction
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000398 mRNA splicing, via spliceosome TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter TAS
 biological_processGO:0006368 transcription elongation from RNA polymerase II promoter TAS
 biological_processGO:0006370 7-methylguanosine mRNA capping TAS
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway TAS
 biological_processGO:0016070 RNA metabolic process TAS
 biological_processGO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter IBA
 biological_processGO:0042795 snRNA transcription by RNA polymerase II TAS
 biological_processGO:0050434 positive regulation of viral transcription TAS
 biological_processGO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter IBA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005674 transcription factor TFIIF complex IBA
 cellular_componentGO:0015630 microtubule cytoskeleton IDA
 cellular_componentGO:0097550 transcriptional preinitiation complex IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000991 transcription factor activity, core RNA polymerase II binding IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Pausing and recovery of Tat-mediated HIV elongation
Abortive elongation of HIV-1 transcript in the absence of Tat
Tat-mediated HIV elongation arrest and recovery
Tat-mediated elongation of the HIV-1 transcript
HIV elongation arrest and recovery
Pausing and recovery of HIV elongation
Viral Messenger RNA Synthesis
RNA Polymerase II Pre-transcription Events
TP53 Regulates Transcription of DNA Repair Genes
FGFR2 alternative splicing
RNA polymerase II transcribes snRNA genes
mRNA Capping
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Pol II CTD phosphorylation and interaction with CE
Signaling by FGFR2 IIIa TM
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000060069 CTDP1 / Q9Y5B0 / CTD phosphatase subunit 1  / reaction
 ENSG00000091831 ESR1 / P03372 / estrogen receptor 1  / complex
 ENSG00000101654 RNMT / O43148 / RNA guanine-7 methyltransferase  / reaction
 ENSG00000129315 CCNT1 / O60563 / cyclin T1  / complex
 ENSG00000134058 CDK7 / P50613 / cyclin dependent kinase 7  / reaction
 ENSG00000165819 METTL3 / Q86U44 / methyltransferase like 3  / reaction
 ENSG00000163161 ERCC3 / P19447 / ERCC excision repair 3, TFIIH core complex helicase subunit  / reaction
 ENSG00000153767 GTF2E1 / P29083 / general transcription factor IIE subunit 1  / complex / reaction
 ENSG00000146457 WTAP / Q15007 / WT1 associated protein  / reaction
 ENSG00000165417 GTF2A1 / P52655 / general transcription factor IIA subunit 1  / complex / reaction
 ENSG00000140307 GTF2A2 / P52657 / general transcription factor IIA subunit 2  / complex / reaction
 ENSG00000135486 P09651 / HNRNPA1 / heterogeneous nuclear ribonucleoprotein A1  / complex / reaction
 ENSG00000114503 NCBP2 / P52298 / nuclear cap binding protein subunit 2  / complex / reaction
 ENSG00000196235 O00267 / SUPT5H / SPT5 homolog, DSIF elongation factor subunit  / reaction
 ENSG00000011304 PTBP1 / P26599 / polypyrimidine tract binding protein 1  / complex / reaction
 ENSG00000197265 GTF2E2 / P29084 / general transcription factor IIE subunit 2  / complex / reaction
 ENSG00000111880 RNGTT / O60942 / RNA guanylyltransferase and 5-phosphatase  / complex / reaction
 ENSG00000136937 NCBP1 / Q09161 / nuclear cap binding protein subunit 1  / complex / reaction
 ENSG00000137947 GTF2B / Q00403 / general transcription factor IIB  / complex / reaction
 ENSG00000125651 GTF2F1 / P35269 / general transcription factor IIF subunit 1  / complex
 ENSG00000136807 CDK9 / P50750 / cyclin dependent kinase 9  / complex
 ENSG00000145388 Q9HCE5 / METTL14 / methyltransferase like 14  / reaction






 

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