ENSG00000136937


Homo sapiens

Features
Gene ID: ENSG00000136937
  
Biological name :NCBP1
  
Synonyms : NCBP1 / nuclear cap binding protein subunit 1 / Q09161
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: 1
Band: q22.33
Gene start: 97633626
Gene end: 97673748
  
Corresponding Affymetrix probe sets: 209519_at (Human Genome U133 Plus 2.0 Array)   209520_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000487569
Ensembl peptide - ENSP00000364272
Ensembl peptide - ENSP00000364289
Ensembl peptide - ENSP00000433007
NCBI entrez gene - 4686     See in Manteia.
OMIM - 600469
RefSeq - XM_017014738
RefSeq - NM_002486
RefSeq - XM_017014735
RefSeq - XM_017014736
RefSeq - XM_017014737
RefSeq Peptide - NP_002477
swissprot - X6R941
swissprot - F2Z2T1
swissprot - A0A024R179
swissprot - Q09161
Ensembl - ENSG00000136937
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NCBP1ENSGALG00000002087Gallus gallus
 Ncbp1ENSMUSG00000028330Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003890  MIF4G-like, type 3
 IPR015172  MIF4G-like, type 1
 IPR015174  MIF4G-like, type 2
 IPR016024  Armadillo-type fold
 IPR027159  Nuclear cap-binding protein subunit 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
 biological_processGO:0000245 spliceosomal complex assembly IMP
 biological_processGO:0000398 mRNA splicing, via spliceosome TAS
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0006368 transcription elongation from RNA polymerase II promoter TAS
 biological_processGO:0006369 termination of RNA polymerase II transcription TAS
 biological_processGO:0006370 7-methylguanosine mRNA capping IEA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006405 RNA export from nucleus TAS
 biological_processGO:0006406 mRNA export from nucleus TAS
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006446 regulation of translational initiation IDA
 biological_processGO:0008334 histone mRNA metabolic process TAS
 biological_processGO:0008380 RNA splicing TAS
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway TAS
 biological_processGO:0016070 RNA metabolic process IEA
 biological_processGO:0030307 positive regulation of cell growth IMP
 biological_processGO:0031047 gene silencing by RNA IEA
 biological_processGO:0031053 primary miRNA processing IBA
 biological_processGO:0031124 mRNA 3"-end processing TAS
 biological_processGO:0031442 positive regulation of mRNA 3"-end processing IMP
 biological_processGO:0042795 snRNA transcription by RNA polymerase II TAS
 biological_processGO:0045292 mRNA cis splicing, via spliceosome IEA
 biological_processGO:0048026 positive regulation of mRNA splicing, via spliceosome IMP
 biological_processGO:0051028 mRNA transport IEA
 biological_processGO:0051168 nuclear export TAS
 biological_processGO:0098789 pre-mRNA cleavage required for polyadenylation IMP
 biological_processGO:1905216 positive regulation of RNA binding IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005845 mRNA cap binding complex IDA
 cellular_componentGO:0005846 nuclear cap binding complex IEA
 cellular_componentGO:0034518 RNA cap binding complex TAS
 molecular_functionGO:0000339 RNA cap binding IEA
 molecular_functionGO:0000340 RNA 7-methylguanosine cap binding IMP
 molecular_functionGO:0003723 RNA binding TAS
 molecular_functionGO:0003729 mRNA binding IBA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Cleavage of Growing Transcript in the Termination Region
SLBP independent Processing of Histone Pre-mRNAs
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Transport of the SLBP independent Mature mRNA
Transport of the SLBP Dependant Mature mRNA
Transport of Mature mRNA Derived from an Intronless Transcript
Transport of Mature mRNA derived from an Intron-Containing Transcript
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
Formation of HIV-1 elongation complex containing HIV-1 Tat
Abortive elongation of HIV-1 transcript in the absence of Tat
snRNP Assembly
RNA Polymerase II Pre-transcription Events
FGFR2 alternative splicing
RNA polymerase II transcribes snRNA genes
mRNA Capping
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway
mRNA 3-end processing
Processing of Capped Intron-Containing Pre-mRNA
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
Processing of Intronless Pre-mRNAs
Signaling by FGFR2 IIIa TM
Regulation of expression of SLITs and ROBOs
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000060069 CTDP1 / Q9Y5B0 / CTD phosphatase subunit 1  / reaction / complex
 ENSG00000213246 P63272 / SUPT4H1 / SPT4 homolog, DSIF elongation factor subunit  / complex / reaction
 ENSG00000101138 CSTF1 / Q05048 / cleavage stimulation factor subunit 1  / complex / reaction
 ENSG00000100227 Q9BY77 / POLDIP3 / DNA polymerase delta interacting protein 3  / complex
 ENSG00000129315 CCNT1 / O60563 / cyclin T1  / reaction
 ENSG00000165819 METTL3 / Q86U44 / methyltransferase like 3  / reaction
 ENSG00000142528 Q8WTR7 / ZNF473 / zinc finger protein 473  / complex / reaction
 ENSG00000164902 PHAX / Q9H814 / phosphorylated adaptor for RNA export  / complex / reaction
 ENSG00000162231 NXF1 / Q9UBU9 / nuclear RNA export factor 1  / reaction
 ENSG00000176102 CSTF3 / Q12996 / cleavage stimulation factor subunit 3  / complex / reaction
 ENSG00000177613 CSTF2T / Q9H0L4 / cleavage stimulation factor subunit 2 tau variant  / complex / reaction
 ENSG00000146457 WTAP / Q15007 / WT1 associated protein  / reaction
 ENSG00000188342 GTF2F2 / P13984 / general transcription factor IIF subunit 2  / complex / reaction
 ENSG00000114503 NCBP2 / P52298 / nuclear cap binding protein subunit 2  / complex / reaction
 ENSG00000163950 SLBP / Q14493 / stem-loop binding protein  / complex / reaction
 ENSG00000114867 EIF4G1 / Q04637 / eukaryotic translation initiation factor 4 gamma 1  / complex
 ENSG00000196235 O00267 / SUPT5H / SPT5 homolog, DSIF elongation factor subunit  / complex / reaction
 ENSG00000082258 CCNT2 / O60583 / cyclin T2  / reaction
 ENSG00000185049 NELFA / Q9H3P2 / negative elongation factor complex member A  / complex / reaction
 ENSG00000135486 P09651 / HNRNPA1 / heterogeneous nuclear ribonucleoprotein A1  / complex / reaction
 ENSG00000188986 NELFB / Q8WX92 / negative elongation factor complex member B  / complex / reaction
 ENSG00000070756 P11940 / PABPC1 / poly(A) binding protein cytoplasmic 1  / complex
 ENSG00000011304 PTBP1 / P26599 / polypyrimidine tract binding protein 1  / complex / reaction
 ENSG00000136807 CDK9 / P50750 / cyclin dependent kinase 9  / reaction
 ENSG00000204356 NELFE / P18615 / negative elongation factor complex member E  / complex / reaction
 ENSG00000090061 CCNK / O75909 / cyclin K  / reaction
 ENSG00000125651 GTF2F1 / P35269 / general transcription factor IIF subunit 1  / complex / reaction
 ENSG00000101811 CSTF2 / P33240 / cleavage stimulation factor subunit 2  / complex / reaction
 ENSG00000145388 Q9HCE5 / METTL14 / methyltransferase like 14  / reaction
 ENSG00000087087 SRRT / Q9BXP5 / serrate, RNA effector molecule  / complex / reaction






 

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