ENSG00000101811


Homo sapiens
cleavagemrnaCSTF2factorprocessingdomainbindingrnaterminationsplicingpolyadenylationstimulationsubunittranscriptionviatrna-endnucleusbodyrecognitionmotifhingec-terminalrna-bindingsuperfamilyspliceosomepolymeraseiiendonucleolyticligationpre-mrna

Features
Gene ID: ENSG00000101811
  
Biological name :CSTF2
  
Synonyms : cleavage stimulation factor subunit 2 / CSTF2 / P33240
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: 1
Band: q22.1
Gene start: 100820359
Gene end: 100840932
  
Corresponding Affymetrix probe sets: 204459_at (Human Genome U133 Plus 2.0 Array)   238821_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000362063
Ensembl peptide - ENSP00000432060
Ensembl peptide - ENSP00000415705
Ensembl peptide - ENSP00000387996
NCBI entrez gene - 1478     See in Manteia.
OMIM - 300907
RefSeq - NM_001306206
RefSeq - NM_001306209
RefSeq - NM_001325
RefSeq Peptide - NP_001293138
RefSeq Peptide - NP_001316
RefSeq Peptide - NP_001293135
swissprot - P33240
swissprot - E7EWR4
swissprot - A0A0A0MT56
swissprot - E9PID8
Ensembl - ENSG00000101811
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cstf2ENSDARG00000090788Danio rerio
 CSTF2ENSGALG00000006760Gallus gallus
 Cstf2ENSMUSG00000031256Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CSTF2T / Q9H0L4 / cleavage stimulation factor subunit 2 tau variantENSG0000017761371


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR025742  Cleavage stimulation factor subunit 2, hinge domain
 IPR026896  Transcription termination and cleavage factor, C-terminal domain
 IPR033105  Cleavage stimulation factor subunit 2
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
nitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processbiosynthetic processresponse to endogenous stimulusresponse to chemicalcellular response to stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processbiosynthetic processresponse to endogenous stimulusresponse to chemicalcellular response to stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processbiosynthetic processresponse to endogenous stimulusresponse to chemicalcellular response to stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processbiosynthetic processresponse to endogenous stimulusresponse to chemicalcellular response to stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processbiosynthetic processresponse to endogenous stimulusresponse to chemicalcellular response to stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processbiosynthetic processresponse to endogenous stimulusresponse to chemicalcellular response to stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processbiosynthetic processresponse to endogenous stimulusresponse to chemicalcellular response to stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processbiosynthetic processresponse to endogenous stimulusresponse to chemicalcellular response to stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processbiosynthetic processresponse to endogenous stimulusresponse to chemicalcellular response to stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processbiosynthetic processresponse to endogenous stimulusresponse to chemicalcellular response to stimulusnitrogen compoundnitrogen compound metabolic processcellular metabolicellular metabolic processprimary metabolicprimary metabolic processorganic substanceorganic substance metabolic processbiosynthetic procbiosynthetic processresponse to endogresponse to endogenous stimulusresponse to chemiresponse to chemicalcellular responsecellular response to stimulus
organic cyclic compound bindingheterocyclic compound bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingorganic cyclic compound bindingorganic cyclic compound bindingheterocyclic compound bindingheterocyclic compound bindingprotein bindingprotein binding
cellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellcellorganelleorganellemembrane-enclosed lumenmembrane-enclosed lumenprotein-containing complexprotein-containing complex
TypeGO IDTermEv.Code
 biological_processGO:0000398 mRNA splicing, via spliceosome TAS
 biological_processGO:0006369 termination of RNA polymerase II transcription TAS
 biological_processGO:0006378 mRNA polyadenylation IEA
 biological_processGO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation TAS
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0031124 mRNA 3"-end processing IEA
 biological_processGO:0098789 pre-mRNA cleavage required for polyadenylation IBA
 biological_processGO:1990090 cellular response to nerve growth factor stimulus IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005847 mRNA cleavage and polyadenylation specificity factor complex IEA
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0071920 cleavage body IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003729 mRNA binding IBA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Cleavage of Growing Transcript in the Termination Region
tRNA processing in the nucleus
mRNA Splicing - Major Pathway
mRNA 3-end processing
Processing of Intronless Pre-mRNAs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000176102 CSTF3 / Q12996 / cleavage stimulation factor subunit 3  / complex
 ENSG00000101138 CSTF1 / Q05048 / cleavage stimulation factor subunit 1  / complex
 ENSG00000114503 NCBP2 / P52298 / nuclear cap binding protein subunit 2  / complex / reaction
 ENSG00000136937 NCBP1 / Q09161 / nuclear cap binding protein subunit 1  / complex / reaction






 

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