ENSG00000204632


Homo sapiens

Features
Gene ID: ENSG00000204632
  
Biological name :HLA-G
  
Synonyms : HLA-G / major histocompatibility complex, class I, G / P17693
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: p22.1
Gene start: 29826967
Gene end: 29831125
  
Corresponding Affymetrix probe sets: 210514_x_at (Human Genome U133 Plus 2.0 Array)   211528_x_at (Human Genome U133 Plus 2.0 Array)   211529_x_at (Human Genome U133 Plus 2.0 Array)   211530_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000436375
Ensembl peptide - ENSP00000366024
Ensembl peptide - ENSP00000412927
Ensembl peptide - ENSP00000353472
Ensembl peptide - ENSP00000366011
Ensembl peptide - ENSP00000366014
NCBI entrez gene - 3135     See in Manteia.
OMIM - 142871
RefSeq - XM_017010818
RefSeq - NM_002127
RefSeq - XM_017010816
RefSeq - XM_017010817
RefSeq Peptide - NP_002118
swissprot - Q31611
swissprot - Q5RJ85
swissprot - Q6DU14
swissprot - P17693
swissprot - Q29897
Ensembl - ENSG00000204632
  
Related genetic diseases (OMIM): 600807 - {Asthma, susceptibility to}, 600807
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Gm11127ENSMUSG00000079492Mus musculus
 Gm7030ENSMUSG00000092243Mus musculus
 Gm8909ENSMUSG00000073402Mus musculus
 H2-BlENSMUSG00000073406Mus musculus
 H2-D1ENSMUSG00000073411Mus musculus
 H2-K1ENSMUSG00000061232Mus musculus
 H2-M1ENSMUSG00000037334Mus musculus
 H2-M11ENSMUSG00000037537Mus musculus
 H2-M2ENSMUSG00000016283Mus musculus
 H2-M3ENSMUSG00000016206Mus musculus
 H2-M5ENSMUSG00000024459Mus musculus
 H2-M9ENSMUSG00000067201Mus musculus
 H2-Q1ENSMUSG00000079507Mus musculus
 H2-Q10ENSMUSG00000067235Mus musculus
 H2-Q2ENSMUSG00000091705Mus musculus
 H2-Q4ENSMUSG00000035929Mus musculus
 H2-Q5ENSMUSG00000055413Mus musculus
 H2-Q6ENSMUSG00000073409Mus musculus
 H2-Q7ENSMUSG00000060550Mus musculus
 H2-T23ENSMUSG00000067212Mus musculus
 H2-T3ENSMUSG00000054128Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HLA-A / P04439 / P13746 / P16188 / major histocompatibility complex, class I, AENSG0000020650383
HLA-B / P30480 / P30486 / Q29836 / Q31610 / Q31612 / P01889 / major histocompatibility complex, class I, BENSG0000023474581
HLA-C / P10321 / major histocompatibility complex, class I, CENSG0000020452580
HLA-F / P30511 / major histocompatibility complex, class I, FENSG0000020464278
HLA-E / major histocompatibility complex, class I, EENSG0000020459276


Protein motifs (from Interpro)
Interpro ID Name
 IPR001039  MHC class I alpha chain, alpha1 alpha2 domains
 IPR003006  Immunoglobulin/major histocompatibility complex, conserved site
 IPR003597  Immunoglobulin C1-set
 IPR007110  Immunoglobulin-like domain
 IPR011161  MHC class I-like antigen recognition-like
 IPR011162  MHC classes I/II-like antigen recognition protein
 IPR013783  Immunoglobulin-like fold
 IPR021157  Cytochrome c1, transmembrane anchor, C-terminal
 IPR036179  Immunoglobulin-like domain superfamily
 IPR037055  MHC class I-like antigen recognition-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002474 antigen processing and presentation of peptide antigen via MHC class I IBA
 biological_processGO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS
 biological_processGO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent TAS
 biological_processGO:0002645 positive regulation of tolerance induction IMP
 biological_processGO:0002666 positive regulation of T cell tolerance induction IMP
 biological_processGO:0002767 immune response-inhibiting cell surface receptor signaling pathway IDA
 biological_processGO:0006968 cellular defense response TAS
 biological_processGO:0032735 positive regulation of interleukin-12 production IDA
 biological_processGO:0042130 negative regulation of T cell proliferation IDA
 biological_processGO:0045591 positive regulation of regulatory T cell differentiation IMP
 biological_processGO:0050776 regulation of immune response TAS
 biological_processGO:0050777 negative regulation of immune response IC
 biological_processGO:0060333 interferon-gamma-mediated signaling pathway TAS
 biological_processGO:0060337 type I interferon signaling pathway TAS
 biological_processGO:2001199 negative regulation of dendritic cell differentiation IDA
 cellular_componentGO:0000139 Golgi membrane TAS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0012507 ER to Golgi transport vesicle membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030670 phagocytic vesicle membrane TAS
 cellular_componentGO:0031901 early endosome membrane TAS
 cellular_componentGO:0042612 MHC class I protein complex IEA
 cellular_componentGO:0055038 recycling endosome membrane TAS
 cellular_componentGO:0071556 integral component of lumenal side of endoplasmic reticulum membrane TAS
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042605 peptide antigen binding IBA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity NAS


Pathways (from Reactome)
Pathway description
ER-Phagosome pathway
Endosomal/Vacuolar pathway
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Interferon gamma signaling
Interferon alpha/beta signaling
Antigen Presentation: Folding, assembly and peptide loading of class I MHC


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000189013 Q99706 / KIR2DL4 / killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4  / complex / reaction
 ENSG00000166710 B2M / P61769 / beta-2-microglobulin  / complex






 

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