ENSG00000215203


Homo sapiens

Features
Gene ID: ENSG00000215203
  
Biological name :GRXCR1
  
Synonyms : A8MXD5 / glutaredoxin and cysteine rich domain containing 1 / GRXCR1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: p13
Gene start: 42893267
Gene end: 43030658
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSP00000382670
NCBI entrez gene - 389207     See in Manteia.
OMIM - 613283
RefSeq - NM_001080476
RefSeq Peptide - NP_001073945
swissprot - A8MXD5
Ensembl - ENSG00000215203
  
Related genetic diseases (OMIM): 613285 - Deafness, autosomal recessive 25, 613285
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 grxcr1ENSDARG00000069865Danio rerio
 GRXCR1ENSDARG00000105434Danio rerio
 GRXCR1ENSGALG00000023032Gallus gallus
 Grxcr1ENSMUSG00000068082Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
A6NFK2 / GRXCR2 / glutaredoxin and cysteine rich domain containing 2ENSG0000020492828


Protein motifs (from Interpro)
Interpro ID Name
 IPR002109  Glutaredoxin
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007605 sensory perception of sound ISS
 biological_processGO:0010923 negative regulation of phosphatase activity IDA
 biological_processGO:0022900 electron transport chain IEA
 biological_processGO:0045454 cell redox homeostasis IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060118 vestibular receptor cell development ISS
 biological_processGO:0060119 inner ear receptor cell development ISS
 biological_processGO:0060122 inner ear receptor cell stereocilium organization ISS
 cellular_componentGO:0005902 microvillus IEA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0032420 stereocilium ISS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0060091 kinocilium ISS
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0009055 electron transfer activity IEA
 molecular_functionGO:0015035 protein disulfide oxidoreductase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000007 Autosomal recessive inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]
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 HP:0000408 Hearing loss, sensorineural, progressive 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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