ENSMUSG00000068082


Mus musculus

Features
Gene ID: ENSMUSG00000068082
  
Biological name :Grxcr1
  
Synonyms : glutaredoxin and cysteine rich domain containing 1 / Grxcr1
  
Possible biological names infered from orthology : A8MXD5
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: C3.1
Gene start: 68031835
Gene end: 68166398
  
Corresponding Affymetrix probe sets: 10522296 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000092305
NCBI entrez gene - 433899     See in Manteia.
MGI - MGI:3577767
RefSeq - NM_001018019
RefSeq Peptide - NP_001018019
swissprot - G3X9N2
Ensembl - ENSMUSG00000068082
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 grxcr1ENSDARG00000069865Danio rerio
 GRXCR1ENSDARG00000105434Danio rerio
 GRXCR1ENSGALG00000023032Gallus gallus
 A8MXD5ENSG00000215203Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Grxcr2 / Q3TYR5 / Glutaredoxin domain-containing cysteine-rich protein 2 / A6NFK2* / glutaredoxin and cysteine rich domain containing 2*ENSMUSG0000007357427


Protein motifs (from Interpro)
Interpro ID Name
 IPR002109  Glutaredoxin
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010923 negative regulation of phosphatase activity IEA
 biological_processGO:0022900 electron transport chain IEA
 biological_processGO:0045454 cell redox homeostasis IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005623 cell IEA
 molecular_functionGO:0009055 electron transfer activity IEA
 molecular_functionGO:0015035 protein disulfide oxidoreductase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000034 abnormal vestibule morphology "malformed cavity between the semicircular canals and the cochlea of the inner ear" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]
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Allelic Composition: Bcat2mpc91H/Bcat2mpc91H
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0000043 organ of Corti degeneration "a retrogressive impairment of function or destruction of the highly specialized epithelium in the floor of the ductus cochlearis" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * Swiss Webster

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
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Allelic Composition: Tas1r2tm1Csz/Tas1r2tm1Csz,Tas1r3tm1Csz/Tas1r3tm1Csz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001395 bi-directional circling "circling behavior exhibited in both clockwise and counterclockwise directions" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * Swiss Webster

Allelic Composition: Grxcr1pi-Tg(Eno2-Gabrb3)0370Brll/Grxcr1pi-Tg(Eno2-Gabrb3)0370Brll
Genetic Background: involves: C3H * C57BL/6J

Allelic Composition: Grxcr1pi-2J/Grxcr1pi-2J
Genetic Background: DBA/2J-Grxcr1pi-2J/J

Allelic Composition: Grxcr1pi-4J/Grxcr1pi-4J
Genetic Background: B6.Cg-Grxcr1pi-4J/J

Allelic Composition: Grxcr1pi-3J/Grxcr1pi-3J
Genetic Background: BKS(Cg)-Grxcr1pi-3J/J

 MP:0001409 increased stereotypic behavior "more frequent incidence of repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, MGI:CLS, J:57125]
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Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * Swiss Webster

 MP:0001410 head bobbing "compulsive up and down movement of the head" [J:17123]
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Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * Swiss Webster

Allelic Composition: Grxcr1pi-Tg(Eno2-Gabrb3)0370Brll/Grxcr1pi-Tg(Eno2-Gabrb3)0370Brll
Genetic Background: involves: C3H * C57BL/6J

Allelic Composition: Grxcr1pi-2J/Grxcr1pi-2J
Genetic Background: DBA/2J-Grxcr1pi-2J/J

Allelic Composition: Grxcr1pi-4J/Grxcr1pi-4J
Genetic Background: B6.Cg-Grxcr1pi-4J/J

 MP:0001522 impaired swimming "reduced ability or inability to swim" [J:45446, J:39081]
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Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * Swiss Webster

Allelic Composition: Grxcr1pi-2J/Grxcr1pi-2J
Genetic Background: DBA/2J-Grxcr1pi-2J/J

Allelic Composition: Grxcr1pi-4J/Grxcr1pi-4J
Genetic Background: B6.Cg-Grxcr1pi-4J/J

Allelic Composition: Grxcr1pi-3J/Grxcr1pi-3J
Genetic Background: BKS(Cg)-Grxcr1pi-3J/J

 MP:0001961 abnormal reflex "anomalies in an involuntary response to a peripheral stimulus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * Swiss Webster

 MP:0001967 deafness "inability to hear" [J:57651]
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Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * Swiss Webster

Allelic Composition: Grxcr1pi/Grxcr1pi
Genetic Background: B6.C3-Grxcr1pi/J

Allelic Composition: Grxcr1pi-Tg(Eno2-Gabrb3)0370Brll/Grxcr1pi-Tg(Eno2-Gabrb3)0370Brll
Genetic Background: involves: C3H * C57BL/6J

Allelic Composition: Grxcr1pi-2J/Grxcr1pi-2J
Genetic Background: DBA/2J-Grxcr1pi-2J/J

Allelic Composition: Grxcr1pi-4J/Grxcr1pi-4J
Genetic Background: B6.Cg-Grxcr1pi-4J/J

Allelic Composition: Grxcr1pi-3J/Grxcr1pi-3J
Genetic Background: BKS(Cg)-Grxcr1pi-3J/J

Allelic Composition: Grxcr1mpc265H/Grxcr1mpc265H
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0002856 abnormal vestibular ganglion morphology "malformation of the group of neurons associated with the vestibular part of the eighth cranial nerve that are involved in equilibration" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * Swiss Webster

 MP:0002857 cochlear ganglion degeneration "loss of neural cell bodies in the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * Swiss Webster

 MP:0003149 abnormal tectorial membrane morphology "malformation, malfunction or absence of the overlaying membrane of cochlear duct, an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells; sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair cell membrane potential, transducing sound into electrical signals" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:77634]
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Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * Swiss Webster

 MP:0004249 abnormal crista ampullaris morphology "anomaly in the elevation found on the inner surface of the ampullae of each semicircular duct; filaments of the vestibular nerve pass through the crista to reach hair cells on its surface; the hair cells are capped by the cupula, a gelatinous protein-polysaccharide mass" [J:60193, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * Swiss Webster

 MP:0004324 vestibular hair cell degeneration "degeneration or loss of the sensory epithelial cells of the maculae and cristae of the membranous labyrinth of the inner ear which are normally in synaptic contact with the vestibular nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tas1r2tm1Csz/Tas1r2tm1Csz,Tas1r3tm1Csz/Tas1r3tm1Csz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004331 saccular macula degeneration "degeneration or loss of the oval neuroepithelial sensory receptor in the anterior wall of the saccule" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * Swiss Webster

 MP:0004362 cochlear hair cell degeneration "degeneration or loss of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tas1r2tm1Csz/Tas1r2tm1Csz,Tas1r3tm1Csz/Tas1r3tm1Csz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Grxcr1pi/Grxcr1pi
Genetic Background: involves: C3H

 MP:0004363 stria vascularis degeneration "degeneration or loss of the stratified, secretory epithelium which lines the upper part of the cochlear spiral ligament and maintains potassium ion homeostasis in the endolymph" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Grxcr1pi/Grxcr1pi
Genetic Background: involves: C3H

 MP:0004393 abnormal cochlear inner hair cell morphology "any structural abnormality in the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve; there is a single row of flask-shaped inner hair cells tightly surrounded by supporting interphalangeal cells; the apical end of each cell is anchored to the cuticular plate and about 100 stereocilia arranged in a more or less linear (or shallow) U-shaped pattern extend from the cell s surface through the cuticular plate into the endolymphic space inferior to the tectorial membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grxcr1pi/Grxcr1pi
Genetic Background: B6.C3-Grxcr1pi/J

Allelic Composition: Grxcr1pi-Tg(Eno2-Gabrb3)0370Brll/Grxcr1pi-Tg(Eno2-Gabrb3)0370Brll
Genetic Background: involves: C3H * C57BL/6J

 MP:0004417 decreased cochlear nerve compound action potential "reduction of the combined potentials resulting from activation of the auditory division of the eighth cranial nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tas1r2tm1Csz/Tas1r2tm1Csz,Tas1r3tm1Csz/Tas1r3tm1Csz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004428 abnormal type I vestibular cell "any structural abnormality in the flask-shaped sensory cells of the maculae and cristae of the vestibular labyrinth of the inner ear, which are normally enclosed in calyx endings of afferent neurons; afferent and efferent nerve fibers of the vestibular nerve synapse with them; from the apical end of each cell a bundle of stereocilia and a kinocilium extend into the otolithic membrane of the maculae or the cupula of the cristae " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grxcr1pi/Grxcr1pi
Genetic Background: B6.C3-Grxcr1pi/J

Allelic Composition: Grxcr1pi-Tg(Eno2-Gabrb3)0370Brll/Grxcr1pi-Tg(Eno2-Gabrb3)0370Brll
Genetic Background: involves: C3H * C57BL/6J

 MP:0004515 abnormal vestibular hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typical staircase-like arrangement of the mechanosensitive hair bundles which are composed of thick long microvilli (stereocilia) and are located at the apical end of vestibular hair cells of the utricle and saccule" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tas1r2tm1Csz/Tas1r2tm1Csz,Tas1r3tm1Csz/Tas1r3tm1Csz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004519 thin vestibular hair cell stereocilia "reduced thickeness of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on vestibular hair cells in a staircase-like pattern" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tas1r2tm1Csz/Tas1r2tm1Csz,Tas1r3tm1Csz/Tas1r3tm1Csz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004521 abnormal cochlear hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typical pattern of arrangement of mechanosensitive hair bundles which are composed of thick long microvilli (stereocilia) and are located at the apical end of cochlear inner and outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tas1r2tm1Csz/Tas1r2tm1Csz,Tas1r3tm1Csz/Tas1r3tm1Csz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004525 thin cochlear hair cell stereocilia "reduced thickness of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on cochlear inner and outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tas1r2tm1Csz/Tas1r2tm1Csz,Tas1r3tm1Csz/Tas1r3tm1Csz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004527 abnormal outer hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typical V or W-like pattern of arrangement of mechanosensitive hair bundles located at the apical end of cochlear OHCs; each hair bundle is normally composed of ~100 nonmotile, actin-filled microvilli (stereocilia) arranged in rows of increasing height and coupled to one another by morphologically distinct links: tip links, horizontal top connectors, shaft connectors, and ankle links; most hair bundles also possess a single motile kinocilium immediately adjacent to the tallest (outermost) row of stereocilia; a fifth link type, the kinocilial link, connects the kinocilium to its neighboring stereocilia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grxcr1pi-Tg(Eno2-Gabrb3)0370Brll/Grxcr1pi-Tg(Eno2-Gabrb3)0370Brll
Genetic Background: involves: C3H * C57BL/6J

 MP:0004532 abnormal inner hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typically linear or U-shaped pattern of arrangement of mechanosensitive hair bundles located at the apical end of cochlear IHCs; each hair bundle is normally composed of ~100 nonmotile, actin-filled microvilli (stereocilia) arranged in rows of increasing height and coupled to one another by morphologically distinct links: tip links, horizontal top connectors, shaft connectors, and ankle links; most hair bundles also possess a single motile kinocilium immediately adjacent to the tallest row of stereocilia; a fifth link type, the kinocilial link, connects the kinocilium to its neighboring stereocilia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grxcr1pi/Grxcr1pi
Genetic Background: B6.C3-Grxcr1pi/J

Allelic Composition: Grxcr1pi-Tg(Eno2-Gabrb3)0370Brll/Grxcr1pi-Tg(Eno2-Gabrb3)0370Brll
Genetic Background: involves: C3H * C57BL/6J

 MP:0004534 decreased inner hair cell stereocilia number "decreased number (or less than the expected 100 or so) of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear inner hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Grxcr1pi/Grxcr1pi
Genetic Background: B6.C3-Grxcr1pi/J

 MP:0004536 short inner hair cell stereocilia "reduced length of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on cochlear inner hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Grxcr1pi/Grxcr1pi
Genetic Background: B6.C3-Grxcr1pi/J

Allelic Composition: Grxcr1pi-3J/Grxcr1pi-3J
Genetic Background: BKS(Cg)-Grxcr1pi-3J/J

 MP:0004578 abnormal cochlear hair bundle tip links "any structural abnormality in single, three-stranded interrow filaments that extend obliquely from the tip of one stereocilium to the lateral side of an adjacent taller stereocilium; in the mouse, tip links are already detectable prenatally and persist throughout life; tips links are thought to gate the mechanotransducer channel, are lost from the cell surface after exposure to either calcium chelator BAPTA or lanthanum, and resist degradation by the protease subtilisin" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Grxcr1pi/Grxcr1pi
Genetic Background: B6.C3-Grxcr1pi/J

 MP:0004742 abnormal vestibular system physiology "any functional anomaly of the sensory system responsible for the sense of head position and movement of the body through space; such anomalies may include impaired balance, dizziness, poor regulation of postural muscle tone and inability to detect quick movements of the head " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grxcr1pi/Grxcr1pi
Genetic Background: involves: C3H

Allelic Composition: Grxcr1pi-2J/Grxcr1pi-2J
Genetic Background: DBA/2J-Grxcr1pi-2J/J

Allelic Composition: Grxcr1pi-3J/Grxcr1pi-3J
Genetic Background: BKS(Cg)-Grxcr1pi-3J/J

 MP:0005307 head tossing "compulsive flailing of the head in multiple directions" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tas1r2tm1Csz/Tas1r2tm1Csz,Tas1r3tm1Csz/Tas1r3tm1Csz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Grxcr1pi-2J/Grxcr1pi-2J
Genetic Background: DBA/2J-Grxcr1pi-2J/J

Allelic Composition: Grxcr1pi-3J/Grxcr1pi-3J
Genetic Background: BKS(Cg)-Grxcr1pi-3J/J

 MP:0006359 absent startle reflex "failure to respond to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Grxcr1pi-Tg(Eno2-Gabrb3)0370Brll/Grxcr1pi-Tg(Eno2-Gabrb3)0370Brll
Genetic Background: involves: C3H * C57BL/6J

 MP:0011063 absent inner hair cell kinocilia "absence of the nonmotile primary cilium that is found at the apical surface of inner hair cells" [GO:0060091]
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Allelic Composition: Grxcr1pi/Grxcr1pi
Genetic Background: B6.C3-Grxcr1pi/J

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Grxcr1pi/Grxcr1pi
Genetic Background: B6.C3-Grxcr1pi/J

Allelic Composition: Grxcr1pi-Tg(Eno2-Gabrb3)0370Brll/Grxcr1pi-Tg(Eno2-Gabrb3)0370Brll
Genetic Background: involves: C3H * C57BL/6J

Allelic Composition: Grxcr1pi-2J/Grxcr1pi-2J
Genetic Background: DBA/2J-Grxcr1pi-2J/J

Allelic Composition: Grxcr1pi-4J/Grxcr1pi-4J
Genetic Background: B6.Cg-Grxcr1pi-4J/J

Allelic Composition: Grxcr1pi-3J/Grxcr1pi-3J
Genetic Background: BKS(Cg)-Grxcr1pi-3J/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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