ENSG00000254093


Homo sapiens
regulationPINX1chromosometelomeraseproteinbindingtelomeretelomericregionmaintenanceviaactivitylocalizationnucleolusmitoticcellnuclearkinetochoreg-patchdomainmetaphaseplatecongressionproliferationgmtransitioncycleubiquitinationstabilitylengthening

Features
Gene ID: ENSG00000254093
  
Biological name :PINX1
  
Synonyms : PIN2/TERF1 interacting telomerase inhibitor 1 / PINX1 / Q96BK5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: p23.1
Gene start: 10764963
Gene end: 10839884
  
Corresponding Affymetrix probe sets: 223907_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000428242
Ensembl peptide - ENSP00000429346
Ensembl peptide - ENSP00000428853
Ensembl peptide - ENSP00000428728
Ensembl peptide - ENSP00000318966
NCBI entrez gene - 54984     See in Manteia.
OMIM - 606505
RefSeq - NM_017884
RefSeq - NM_001284356
RefSeq Peptide - NP_001271285
RefSeq Peptide - NP_060354
swissprot - Q96BK5
swissprot - E5RGR1
swissprot - H0YBF0
swissprot - E5RJG9
Ensembl - ENSG00000254093
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pinx1ENSDARG00000023532Danio rerio
 PINX1ENSGALG00000041139Gallus gallus
 Pinx1ENSMUSG00000021958Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000467  G-patch domain


Gene Ontology (GO)
nitrogen compound metabolic processbiosynthetic processcellular component organizationcellular metabolic processprimary metabolic processregulation of biological qualityorganic substance metabolic processestablishment of localizationcell cyclecellular localizationchromosome segregationregulation of molecular functionmacromolecule localizationnitrogen compound metabolic processbiosynthetic processcellular component organizationcellular metabolic processprimary metabolic processregulation of biological qualityorganic substance metabolic processestablishment of localizationcell cyclecellular localizationchromosome segregationregulation of molecular functionmacromolecule localizationnitrogen compound metabolic processbiosynthetic processcellular component organizationcellular metabolic processprimary metabolic processregulation of biological qualityorganic substance metabolic processestablishment of localizationcell cyclecellular localizationchromosome segregationregulation of molecular functionmacromolecule localizationnitrogen compound metabolic processbiosynthetic processcellular component organizationcellular metabolic processprimary metabolic processregulation of biological qualityorganic substance metabolic processestablishment of localizationcell cyclecellular localizationchromosome segregationregulation of molecular functionmacromolecule localizationnitrogen compound metabolic processbiosynthetic processcellular component organizationcellular metabolic processprimary metabolic processregulation of biological qualityorganic substance metabolic processestablishment of localizationcell cyclecellular localizationchromosome segregationregulation of molecular functionmacromolecule localizationnitrogen compound metabolic processbiosynthetic processcellular component organizationcellular metabolic processprimary metabolic processregulation of biological qualityorganic substance metabolic processestablishment of localizationcell cyclecellular localizationchromosome segregationregulation of molecular functionmacromolecule localizationnitrogen compound metabolic processbiosynthetic processcellular component organizationcellular metabolic processprimary metabolic processregulation of biological qualityorganic substance metabolic processestablishment of localizationcell cyclecellular localizationchromosome segregationregulation of molecular functionmacromolecule localizationnitrogen compound metabolic processbiosynthetic processcellular component organizationcellular metabolic processprimary metabolic processregulation of biological qualityorganic substance metabolic processestablishment of localizationcell cyclecellular localizationchromosome segregationregulation of molecular functionmacromolecule localizationnitrogen compound metabolic processbiosynthetic processcellular component organizationcellular metabolic processprimary metabolic processregulation of biological qualityorganic substance metabolic processestablishment of localizationcell cyclecellular localizationchromosome segregationregulation of molecular functionmacromolecule localizationnitrogen compound metabolic processbiosynthetic processcellular component organizationcellular metabolic processprimary metabolic processregulation of biological qualityorganic substance metabolic processestablishment of localizationcell cyclecellular localizationchromosome segregationregulation of molecular functionmacromolecule localizationnitrogen cnitrogen compound metabolic processbiosynthetbiosynthetic processcellular ccellular component organizationcellular mcellular metabolic processprimary meprimary metabolic processregulationregulation of biological qualityorganic suorganic substance metabolic processestablishmestablishment of localizationcell cyclecell cyclecellular lcellular localizationchromosomechromosome segregationregulationregulation of molecular functionmacromolecmacromolecule localization
organic cyclic compound bindingheterocyclic compound bindingprotein bindingenzyme regulator activityprotein-containing complex bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingenzyme regulator activityprotein-containing complex bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingenzyme regulator activityprotein-containing complex bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingenzyme regulator activityprotein-containing complex bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingenzyme regulator activityprotein-containing complex bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingenzyme regulator activityprotein-containing complex bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingenzyme regulator activityprotein-containing complex bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingenzyme regulator activityprotein-containing complex bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingenzyme regulator activityprotein-containing complex bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingenzyme regulator activityprotein-containing complex bindingorganic cyclic compound bindorganic cyclic compound bindingheterocyclic compound bindinheterocyclic compound bindingprotein bindingprotein bindingenzyme regulator activityenzyme regulator activityprotein-containing complex bprotein-containing complex binding
cellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellcellorganelleorganellemembrane-enclosed lumenmembrane-enclosed lumenprotein-containing complexprotein-containing complex
TypeGO IDTermEv.Code
 biological_processGO:0007004 telomere maintenance via telomerase IDA
 biological_processGO:0007080 mitotic metaphase plate congression IMP
 biological_processGO:0008285 negative regulation of cell proliferation NAS
 biological_processGO:0010972 negative regulation of G2/M transition of mitotic cell cycle IDA
 biological_processGO:0031397 negative regulation of protein ubiquitination IMP
 biological_processGO:0031647 regulation of protein stability IMP
 biological_processGO:0032211 negative regulation of telomere maintenance via telomerase IMP
 biological_processGO:0051972 regulation of telomerase activity TAS
 biological_processGO:0051974 negative regulation of telomerase activity NAS
 biological_processGO:0070198 protein localization to chromosome, telomeric region IMP
 biological_processGO:1902570 protein localization to nucleolus IDA
 biological_processGO:1904357 negative regulation of telomere maintenance via telomere lengthening NAS
 biological_processGO:1904744 positive regulation of telomeric DNA binding IDA
 biological_processGO:1904751 positive regulation of protein localization to nucleolus IDA
 cellular_componentGO:0000228 nuclear chromosome IDA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0000781 chromosome, telomeric region IDA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005730 nucleolus NAS
 cellular_componentGO:0005819 spindle IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0010521 telomerase inhibitor activity TAS
 molecular_functionGO:0044877 protein-containing complex binding IPI
 molecular_functionGO:0070034 telomerase RNA binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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