ENSMUSG00000021958


Mus musculus

Features
Gene ID: ENSMUSG00000021958
  
Biological name :Pinx1
  
Synonyms : PIN2/TERF1-interacting telomerase inhibitor 1 / Pinx1 / Q9CZX5
  
Possible biological names infered from orthology : Q96BK5
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: D1
Gene start: 63860364
Gene end: 63919859
  
Corresponding Affymetrix probe sets: 10415875 (MoGene1.0st)   1421089_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022528
NCBI entrez gene - 72400     See in Manteia.
MGI - MGI:1919650
RefSeq - NM_028228
RefSeq - XM_006519595
RefSeq Peptide - NP_082504
swissprot - Q9CZX5
Ensembl - ENSMUSG00000021958
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pinx1ENSDARG00000023532Danio rerio
 PINX1ENSGALG00000041139Gallus gallus
 PINX1ENSG00000254093Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000467  G-patch domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007004 telomere maintenance via telomerase IEA
 biological_processGO:0007080 mitotic metaphase plate congression IEA
 biological_processGO:0010972 negative regulation of G2/M transition of mitotic cell cycle IEA
 biological_processGO:0031397 negative regulation of protein ubiquitination IEA
 biological_processGO:0031647 regulation of protein stability IEA
 biological_processGO:0032211 negative regulation of telomere maintenance via telomerase IEA
 biological_processGO:0051974 negative regulation of telomerase activity IEA
 biological_processGO:0070198 protein localization to chromosome, telomeric region IEA
 biological_processGO:1902570 protein localization to nucleolus IEA
 biological_processGO:1904744 positive regulation of telomeric DNA binding IEA
 biological_processGO:1904751 positive regulation of protein localization to nucleolus IEA
 cellular_componentGO:0000228 nuclear chromosome IEA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore ISO
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0000781 chromosome, telomeric region ISO
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005819 spindle IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0010521 telomerase inhibitor activity IEA
 molecular_functionGO:0044877 protein-containing complex binding IEA
 molecular_functionGO:0070034 telomerase RNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001214 skin hyperplasia "increased cell number in the skin; usually results in thick skin" [J:47225]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Tg(Trpv1-cre)1Hoon/0
Genetic Background: involves: 129S1/Sv

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Tg(Trpv1-cre)1Hoon/0
Genetic Background: involves: 129S1/Sv

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Tg(Trpv1-cre)1Hoon/0
Genetic Background: involves: 129S1/Sv

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Tg(Trpv1-cre)1Hoon/0
Genetic Background: involves: 129S1/Sv

Allelic Composition: Pinx1tm1.1Kplu/Pinx1+,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Tg(Trpv1-cre)1Hoon/0
Genetic Background: involves: 129S1/Sv

 MP:0002038 carcinoma "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Tg(Trpv1-cre)1Hoon/0
Genetic Background: involves: 129S1/Sv

Allelic Composition: Pinx1tm1.1Kplu/Pinx1+,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

Allelic Composition: Pinx1tm1.1Kplu/Pinx1+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pinx1tm1.1Kplu/Pinx1+,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

Allelic Composition: Pinx1tm1.1Kplu/Pinx1+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0003155 abnormal telomere length "abnormal length of the terminal section of a chromosome which has a specialized structure and which is involved in chromosomal replication and stability; normal length is a few hundred base pairs" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Tg(Trpv1-cre)1Hoon/0
Genetic Background: involves: 129S1/Sv

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Pinx1tm1.1Kplu/Pinx1+,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

Allelic Composition: Pinx1tm1.1Kplu/Pinx1+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0003667 hemangiosarcoma "a malignant tumor characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and appear as irregular blood-filled or lumpy sacs that are typically filled with blood; rupture of the tumor can cause rapid death from bleeding" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:53511]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Tg(Trpv1-cre)1Hoon/0
Genetic Background: involves: 129S1/Sv

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Tg(Trpv1-cre)1Hoon/0
Genetic Background: involves: 129S1/Sv

 MP:0004086 absent heartbeat "lack of a spontaneously beating heart (usually due to defects in the calcium delivery mechanism or loss of a functional contractile apparatus)" [J:69362, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Tg(Trpv1-cre)1Hoon/0
Genetic Background: involves: 129S1/Sv

 MP:0008000 ovary tumor "presence of abnormal rapidly proliferating cells in the ovary, usually in the form of a distinct mass" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pinx1tm1.1Kplu/Pinx1+,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0008014 lung tumor "presence of abnormal, rapidly proliferating cells on the lung usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Tg(Trpv1-cre)1Hoon/0
Genetic Background: involves: 129S1/Sv

Allelic Composition: Pinx1tm1.1Kplu/Pinx1+,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0008019 liver tumor "presence of abnormal, rapidly proliferating cells in the liver usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Tg(Trpv1-cre)1Hoon/0
Genetic Background: involves: 129S1/Sv

Allelic Composition: Pinx1tm1.1Kplu/Pinx1+,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

Allelic Composition: Pinx1tm1.1Kplu/Pinx1+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0008714 lung carcinoma "a malignant neoplasm of the ling, arising from epithelial cells, usually glandular or squamous" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pinx1tm1.1Kplu/Pinx1+,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

Allelic Composition: Pinx1tm1.1Kplu/Pinx1+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0008866 chromosomal instability "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Tg(Trpv1-cre)1Hoon/0
Genetic Background: involves: 129S1/Sv

 MP:0009321 histiocytic sarcoma 
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Tg(Trpv1-cre)1Hoon/0
Genetic Background: involves: 129S1/Sv

 MP:0010279 increased gastrointestinal tumor incidence "greater than the expected number of tumors originating in the gastrointestinal system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Tg(Trpv1-cre)1Hoon/0
Genetic Background: involves: 129S1/Sv

Allelic Composition: Pinx1tm1.1Kplu/Pinx1+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0010299 increased mammary gland tumor incidence "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Tg(Trpv1-cre)1Hoon/0
Genetic Background: involves: 129S1/Sv

Allelic Composition: Pinx1tm1.1Kplu/Pinx1+,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

Allelic Composition: Pinx1tm1.1Kplu/Pinx1+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0010344 increased hibernoma incidence "greater than the expected number of a benign neoplasm derived from brown fat occurring in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Tg(Trpv1-cre)1Hoon/0
Genetic Background: involves: 129S1/Sv

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Tg(Trpv1-cre)1Hoon/0
Genetic Background: involves: 129S1/Sv

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Tg(Trpv1-cre)1Hoon/0
Genetic Background: involves: 129S1/Sv

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Tg(Trpv1-cre)1Hoon/0
Genetic Background: involves: 129S1/Sv

Allelic Composition: Pinx1tm1.1Kplu/Pinx1+,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

Allelic Composition: Pinx1tm1.1Kplu/Pinx1+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0013538 increased Harderian gland adenoma incidence "greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in the Harderian gland, occurring in a specific population in a given time period " [MGI:Anna]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Tg(Trpv1-cre)1Hoon/0
Genetic Background: involves: 129S1/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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