ENSG00000257335


Homo sapiens

Features
Gene ID: ENSG00000257335
  
Biological name :MGAM
  
Synonyms : maltase-glucoamylase / MGAM / O43451
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: q34
Gene start: 141907813
Gene end: 142106747
  
Corresponding Affymetrix probe sets: 206522_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000482292
Ensembl peptide - ENSP00000417103
Ensembl peptide - ENSP00000417515
Ensembl peptide - ENSP00000419372
Ensembl peptide - ENSP00000447378
NCBI entrez gene - 8972     See in Manteia.
OMIM - 154360
RefSeq - XM_017012772
RefSeq - XM_011516670
RefSeq - XM_011516671
RefSeq - XM_011516672
RefSeq - XM_011516673
RefSeq - XM_011516674
RefSeq - NM_004668
RefSeq - XM_006716168
RefSeq Peptide - NP_004659
swissprot - E9PEQ5
swissprot - E7EW87
swissprot - E7ER45
swissprot - O43451
Ensembl - ENSG00000257335
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01079192.1ENSDARG00000101629Danio rerio
 CABZ01088484.1ENSDARG00000104569Danio rerio
 MgamENSMUSG00000068587Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MGAM2 / Q2M2H8 / maltase-glucoamylase 2 (putative)ENSG0000025774365
SI / P14410 / sucrase-isomaltaseENSG0000009040258
GAA / P10253 / glucosidase alpha, acidENSG0000017129821
GANAB / Q14697 / glucosidase II alpha subunitENSG0000008959713
GANC / Q8TET4 / glucosidase alpha, neutral CENSG0000021401313
MYORG / Q6NSJ0 / myogenesis regulating glycosidase (putative)ENSG000001649768


Protein motifs (from Interpro)
Interpro ID Name
 IPR000322  Glycoside hydrolase family 31
 IPR000519  P-type trefoil domain
 IPR011013  Galactose mutarotase-like domain superfamily
 IPR017853  Glycoside hydrolase superfamily
 IPR017957  P-type trefoil, conserved site
 IPR030458  Glycosyl hydrolases family 31, active site
 IPR030459  Glycosyl hydrolases family 31, conserved site
 IPR031727  Galactose mutarotase, N-terminal barrel


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000023 maltose metabolic process IEA
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0005983 starch catabolic process TAS
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0044245 polysaccharide digestion TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0070821 tertiary granule membrane TAS
 cellular_componentGO:0101003 ficolin-1-rich granule membrane TAS
 molecular_functionGO:0003824 catalytic activity TAS
 molecular_functionGO:0004339 glucan 1,4-alpha-glucosidase activity IEA
 molecular_functionGO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds IEA
 molecular_functionGO:0004558 alpha-1,4-glucosidase activity TAS
 molecular_functionGO:0016160 amylase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016798 hydrolase activity, acting on glycosyl bonds IEA
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0032450 maltose alpha-glucosidase activity IEA
 molecular_functionGO:0090599 alpha-glucosidase activity IEA


Pathways (from Reactome)
Pathway description
Digestion of dietary carbohydrate
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000257335 MGAM / O43451 / maltase-glucoamylase  / complex






 

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