ENSG00000274576


Homo sapiens

Features
Gene ID: ENSG00000274576
  
Biological name :IGHV2-70
  
Synonyms : IGHV2-70 / immunoglobulin heavy variable 2-70 / P01814
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: -1
Band: q32.33
Gene start: 106770577
Gene end: 106771020
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSP00000485200
swissprot - P01814
Ensembl - ENSG00000274576
  
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000040159Gallus gallus
 Ighv8-11ENSMUSG00000095170Mus musculus
 Ighv8-12ENSMUSG00000076731Mus musculus
 Ighv8-13ENSMUSG00000076733Mus musculus
 Ighv8-2ENSMUSG00000102301Mus musculus
 Ighv8-4ENSMUSG00000096355Mus musculus
 Ighv8-5ENSMUSG00000102364Mus musculus
 Ighv8-6ENSMUSG00000094505Mus musculus
 Ighv8-8ENSMUSG00000104452Mus musculus
 Ighv8-9ENSMUSG00000095117Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IGHV2-70D / A0A0C4DH43 / immunoglobulin heavy variable 2-70DENSG0000021197497
P01817 / IGHV2-5 / immunoglobulin heavy variable 2-5ENSG0000021193787
IGHV2-26 / A0A0B4J1V2 / immunoglobulin heavy variable 2-26ENSG0000021195184
IGHV2OR16-5 / immunoglobulin heavy variable 2/OR16-5 (non-functional)ENSG0000025930384
IGHV4-61 / A0A0C4DH41 / immunoglobulin heavy variable 4-61ENSG0000021197057
P01824 / IGHV4-39 / immunoglobulin heavy variable 4-39ENSG0000021195956
IGHV4-28 / A0A0C4DH34 / immunoglobulin heavy variable 4-28ENSG0000021195255
P01825 / IGHV4-59 / immunoglobulin heavy variable 4-59ENSG0000022437355
IGHV4-4 / A0A075B6R2 / immunoglobulin heavy variable 4-4ENSG0000027677554
AC135068.2ENSG0000027826354
IGHV4OR15-8 / immunoglobulin heavy variable 4/OR15-8 (non-functional)ENSG0000025926153
P06331 / IGHV4-34 / immunoglobulin heavy variable 4-34ENSG0000021195651
IGHV6-1 / A0A0B4J1U7 / immunoglobulin heavy variable 6-1ENSG0000021193348


Protein motifs (from Interpro)
Interpro ID Name
No match


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006898 receptor-mediated endocytosis TAS
 biological_processGO:0006955 immune response NAS
 biological_processGO:0006956 complement activation TAS
 biological_processGO:0006958 complement activation, classical pathway TAS
 biological_processGO:0030449 regulation of complement activation TAS
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway TAS
 biological_processGO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
 biological_processGO:0050776 regulation of immune response TAS
 biological_processGO:0050900 leukocyte migration TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0003823 antigen binding NAS
 molecular_functionGO:0004252 serine-type endopeptidase activity TAS


Pathways (from Reactome)
Pathway description
Initial triggering of complement
Classical antibody-mediated complement activation
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Cell surface interactions at the vascular wall
FCGR activation
Regulation of actin dynamics for phagocytic cup formation
Role of phospholipids in phagocytosis
Scavenging of heme from plasma
Fc epsilon receptor (FCERI) signaling
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated NF-kB activation
CD22 mediated BCR regulation
Regulation of Complement cascade
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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