ENSMUSG00000076731


Mus musculus

Features
Gene ID: ENSMUSG00000076731
  
Biological name :Ighv8-12
  
Synonyms : Ighv8-12
  
Possible biological names infered from orthology : A0A0B4J1V2 / A0A0C4DH43 / IGHV2-26 / IGHV2-5 / IGHV2-70 / IGHV2-70D / IGHV2OR16-5 / immunoglobulin heavy variable 2-26 / immunoglobulin heavy variable 2-5 / immunoglobulin heavy variable 2-70 / immunoglobulin heavy variable 2-70D / immunoglobulin heavy variable 2/OR16-5 (non-functional) / P01814 / P01817
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: F2
Gene start: 115647945
Gene end: 115648387
  
Corresponding Affymetrix probe sets: 10403034 (MoGene1.0st)   10403063 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000100321
Ensembl peptide - ENSMUSP00000142333
MGI - MGI:3642873
swissprot - A0A075B5X8
swissprot - A0A0G2JDE1
Ensembl - ENSMUSG00000076731
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000040159Gallus gallus
 IGHV2-26ENSG00000211951Homo sapiens
 IGHV2-70DENSG00000211974Homo sapiens
 IGHV2OR16-5ENSG00000259303Homo sapiens
 P01814ENSG00000274576Homo sapiens
 P01817ENSG00000211937Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ighv8-9 / P01817* / P01814* / IGHV2-5* / IGHV2-70* / IGHV2-26* / IGHV2-70D* / A0A0B4J1V2* / A0A0C4DH43* / IGHV2OR16-5* / immunoglobulin heavy variable 2-5* / immunoglobulin heavy variable 2...ENSMUSG0000009511792
Ighv8-6 / P01817* / P01814* / IGHV2-5* / IGHV2-70* / IGHV2-26* / IGHV2-70D* / A0A0B4J1V2* / A0A0C4DH43* / IGHV2OR16-5* / immunoglobulin heavy variable 2-5* / immunoglobulin heavy variable 2...ENSMUSG0000009450591
Ighv8-5 / P01817* / P01814* / IGHV2-5* / IGHV2-70* / IGHV2-26* / IGHV2-70D* / A0A0B4J1V2* / A0A0C4DH43* / IGHV2OR16-5* / immunoglobulin heavy variable 2-5* / immunoglobulin heavy variable 2...ENSMUSG0000010236491
Ighv8-8 / P01817* / P01814* / IGHV2-5* / IGHV2-70* / IGHV2-26* / IGHV2-70D* / A0A0B4J1V2* / A0A0C4DH43* / IGHV2OR16-5* / immunoglobulin heavy variable 2-5* / immunoglobulin heavy variable 2...ENSMUSG0000010445291
Ighv8-11 / P01817* / P01814* / IGHV2-5* / IGHV2-70* / IGHV2-26* / IGHV2-70D* / A0A0B4J1V2* / A0A0C4DH43* / IGHV2OR16-5* / immunoglobulin heavy variable 2-5* / immunoglobulin heavy variable ...ENSMUSG0000009517087
Ighv8-13 / P01817* / P01814* / IGHV2-5* / IGHV2-70* / IGHV2-26* / IGHV2-70D* / A0A0B4J1V2* / A0A0C4DH43* / IGHV2OR16-5* / immunoglobulin heavy variable 2-5* / immunoglobulin heavy variable ...ENSMUSG0000007673380
Ighv8-2 / P01817* / P01814* / IGHV2-5* / IGHV2-70* / IGHV2-26* / IGHV2-70D* / A0A0B4J1V2* / A0A0C4DH43* / IGHV2OR16-5* / immunoglobulin heavy variable 2-5* / immunoglobulin heavy variable 2...ENSMUSG0000010230179
Ighv8-4 / P01817* / P01814* / IGHV2-5* / IGHV2-70* / IGHV2-26* / IGHV2-70D* / A0A0B4J1V2* / A0A0C4DH43* / IGHV2OR16-5* / immunoglobulin heavy variable 2-5* / immunoglobulin heavy variable 2...ENSMUSG0000009635577
P18531 / Ighv3-6 / Ig heavy chain V region 3-6 ENSMUSG0000007667251
Ighv3-5ENSMUSG0000007667050
Ighv3-1ENSMUSG0000009383850
Ighv3-8ENSMUSG0000007667449
Ighv3-3ENSMUSG0000009402949
Ighv3-4ENSMUSG0000010393948


Protein motifs (from Interpro)
Interpro ID Name
No match


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006910 phagocytosis, recognition IBA
 biological_processGO:0006911 phagocytosis, engulfment IBA
 biological_processGO:0006958 complement activation, classical pathway IBA
 biological_processGO:0042742 defense response to bacterium IBA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0050853 B cell receptor signaling pathway IBA
 biological_processGO:0050871 positive regulation of B cell activation IBA
 cellular_componentGO:0009897 external side of plasma membrane IBA
 cellular_componentGO:0042571 immunoglobulin complex, circulating IBA
 cellular_componentGO:0072562 blood microparticle IBA
 molecular_functionGO:0003823 antigen binding IBA
 molecular_functionGO:0034987 immunoglobulin receptor binding IBA


Pathways (from Reactome)
Pathway description
Initial triggering of complement
Classical antibody-mediated complement activation
Cell surface interactions at the vascular wall
FCGR activation
Regulation of actin dynamics for phagocytic cup formation
Role of phospholipids in phagocytosis
Scavenging of heme from plasma
Fc epsilon receptor (FCERI) signaling
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated NF-kB activation
CD22 mediated BCR regulation
Regulation of Complement cascade
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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