ENSG00000276747


Homo sapiens

Features
Gene ID: ENSG00000276747
  
Biological name :PADI6
  
Synonyms : PADI6 / peptidyl arginine deiminase 6 / Q6TGC4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p36.13
Gene start: 17372196
Gene end: 17401699
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSP00000483125
NCBI entrez gene - 353238     See in Manteia.
OMIM - 610363
RefSeq - NM_207421
RefSeq Peptide - NP_997304
swissprot - Q6TGC4
Ensembl - ENSG00000276747
  
Related genetic diseases (OMIM): 617234 - Preimplantation embryonic lethality 2, 617234
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Padi6ENSMUSG00000040935Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PADI4 / Q9UM07 / peptidyl arginine deiminase 4ENSG0000015933944
PADI2 / Q9Y2J8 / peptidyl arginine deiminase 2ENSG0000011711543
PADI1 / Q9ULC6 / peptidyl arginine deiminase 1ENSG0000014262343
PADI3 / Q9ULW8 / peptidyl arginine deiminase 3ENSG0000014261942


Protein motifs (from Interpro)
Interpro ID Name
 IPR004303  Protein-arginine deiminase
 IPR008972  Cupredoxin
 IPR013530  Protein-arginine deiminase, C-terminal
 IPR013732  Protein-arginine deiminase (PAD) N-terminal
 IPR013733  Protein-arginine deiminase (PAD), central domain
 IPR036556  Protein-arginine deiminase, central domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007010 cytoskeleton organization IEA
 biological_processGO:0007028 cytoplasm organization IEA
 biological_processGO:0018101 protein citrullination IEA
 biological_processGO:0034613 cellular protein localization IEA
 biological_processGO:0036414 histone citrullination IBA
 biological_processGO:0043143 regulation of translation by machinery localization IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0045111 intermediate filament cytoskeleton IEA
 molecular_functionGO:0004668 protein-arginine deiminase activity IBA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Chromatin modifying enzymes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000007 Autosomal recessive inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr