Manteia

ENSG00000278196

Homo sapiens

Features

Gene ID:	ENSG00000278196

Biological name :	IGLV2-8

Synonyms :	IGLV2-8 / immunoglobulin lambda variable 2-8 / P01709

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	22
Strand:	1
Band:	q11.22
Gene start:	22822658
Gene end:	22823289

Corresponding Affymetrix probe sets:	217148_x_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000482937 swissprot - P01709 Ensembl - ENSG00000278196

See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
	ENSGALG00000039268	Gallus gallus
	ENSGALG00000034721	Gallus gallus
	ENSGALG00000005937	Gallus gallus
	ENSGALG00000030653	Gallus gallus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
P01706 / IGLV2-11 / immunoglobulin lambda variable 2-11	ENSG00000211668	93
IGLV2-18 / A0A075B6J9 / immunoglobulin lambda variable 2-18	ENSG00000211664	90
P01704 / IGLV2-14 / immunoglobulin lambda variable 2-14	ENSG00000211666	90
P01705 / IGLV2-23 / immunoglobulin lambda variable 2-23	ENSG00000211660	86
P01703 / IGLV1-40 / immunoglobulin lambda variable 1-40	ENSG00000211653	71
IGLV2-33 / immunoglobulin lambda variable 2-33 (non-functional)	ENSG00000211656	71
IGLV1-50 / immunoglobulin lambda variable 1-50 (non-functional)	ENSG00000211645	67
P01700 / IGLV1-47 / immunoglobulin lambda variable 1-47	ENSG00000211648	67
P01699 / IGLV1-44 / immunoglobulin lambda variable 1-44	ENSG00000211651	67
P01721 / IGLV6-57 / immunoglobulin lambda variable 6-57	ENSG00000211640	65
P01701 / IGLV1-51 / immunoglobulin lambda variable 1-51	ENSG00000211644	64
IGLV1-36 / A0A0B4J1U3 / immunoglobulin lambda variable 1-36	ENSG00000211655	63
P01717 / IGLV3-25 / immunoglobulin lambda variable 3-25	ENSG00000211659	58
P01714 / IGLV3-19 / immunoglobulin lambda variable 3-19	ENSG00000211663	58
IGLV3-10 / A0A075B6K4 / immunoglobulin lambda variable 3-10	ENSG00000211669	58
P01715 / IGLV3-1 / immunoglobulin lambda variable 3-1	ENSG00000211673	57
IGLV3-16 / A0A075B6K0 / immunoglobulin lambda variable 3-16	ENSG00000211665	56
IGLV3-22 / A0A075B6J6 / immunoglobulin lambda variable 3-22 (gene/pseudogene)	ENSG00000211661	55
IGLV3-9 / A0A075B6K5 / immunoglobulin lambda variable 3-9 (gene/pseudogene)	ENSG00000211670	55
P01718 / IGLV3-27 / immunoglobulin lambda variable 3-27	ENSG00000211658	54

Protein motifs (from Interpro)

Interpro ID

Name

No match

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0002250	adaptive immune response	IEA
biological_process	GO:0002376	immune system process	IEA
biological_process	GO:0006508	proteolysis	IEA
biological_process	GO:0006898	receptor-mediated endocytosis	TAS
biological_process	GO:0006955	immune response	NAS
biological_process	GO:0006956	complement activation	TAS
biological_process	GO:0006958	complement activation, classical pathway	TAS
biological_process	GO:0030449	regulation of complement activation	TAS
biological_process	GO:0038095	Fc-epsilon receptor signaling pathway	TAS
biological_process	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	TAS
biological_process	GO:0050776	regulation of immune response	TAS
biological_process	GO:0050900	leukocyte migration	TAS
cellular_component	GO:0005576	extracellular region	TAS
cellular_component	GO:0005886	plasma membrane	TAS
cellular_component	GO:0016020	membrane	IEA
molecular_function	GO:0003823	antigen binding	NAS
molecular_function	GO:0004252	serine-type endopeptidase activity	TAS

Pathways (from Reactome)

Pathway description

Initial triggering of complement

Classical antibody-mediated complement activation

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Cell surface interactions at the vascular wall

FCGR activation

Regulation of actin dynamics for phagocytic cup formation

Role of phospholipids in phagocytosis

Scavenging of heme from plasma

Fc epsilon receptor (FCERI) signaling

Role of LAT2/NTAL/LAB on calcium mobilization

FCERI mediated MAPK activation

FCERI mediated Ca+2 mobilization

FCERI mediated NF-kB activation

CD22 mediated BCR regulation

Regulation of Complement cascade

Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr